Abstract: A method for synthesizing 4-hydroxy-3,5-diiodobenzyl alcohol. The synthesis method includes, in just one step, the synthesis of 4-hydroxy-3,5-diiodobenzyl alcohol from 4-hydroxybenzylalcohol, in an aqueous medium at an initial pH of at least 7, containing at least 2 equivalents of diiodide. The method is simple and makes it possible to achieve very good yields at a lower cost.

Abstract: A method for synthesizing 4-hydroxy-3,5-diiodobenzyl alcohol. The synthesis method includes, in just one step, the synthesis of 4-hydroxy-3,5-diiodobenzyl alcohol from 4-hydroxybenzylalcohol, in an aqueous medium at an initial pH of at least 7, containing at least 2 equivalents of diiodide. The method is simple and makes it possible to achieve very good yields at a lower cost.

Abstract: The invention relates to a 5-acylsulfanyl-histidine compound and the derivatives thereof, of general formula (I), wherein R1 to R3=H, alkyl, especially CH3; R4=H, alkyl, especially CH3, alkyle (C=0), substituted alkyl (C?O), aryl (C?O); ?-alanyl (H2NCH2CH2 (C?O); ?-amino-acyl; R5=alkyl, especially methyl, phenyl. The invention also relates to the use of said compound for producing of 5-sulfanyl-histidine compounds and the derivatives thereof of formula (II) in addition to corresponding disulfides as well as these 5-sulfanylhistidines of formula (II) as novel compounds and their use as antioxidant; and to the various methods for the production thereof.

Abstract: The invention relates to a selenium compound. Said selenium compound has formula (I), where R1=alkyl; R2=H, R4C(=0), R4OC(=0), a-aminoacyl, CH3SeCH2CH2CH(NH2)C(=0), CH3SeCH2CH2CH(OH)C(=0); X=OH, OR3, NH2, NR4R5, ?-amino acid, CH3SeCH2CH2CH(COOH)NH—, CH3SeCH2CH2CH(COOH)0-; R3=alkyl; R4=alkyl, aryl; R5=H, alkyl, aryl; R4 and R5 which can together form a 5- or 6-membered cycloalkyl radical which can comprise a heteroatom; provided that when X=NH-terbutyl, R2?C(=0)CH3. Said compound can be used as a pharmaceutical substance, in particular as an antitumour substance.

Abstract: The invention relates to a compound of the 5-acylsulfanyl-histidine type and the derivatives thereof, of general formula (I), wherein R1 to R3=H, alkyl, especially CH3; R4=H, alkyl, especially CH3, alkyle(C=0), substituted alkyl (C?O), aryl (C?O); ?-alanyl (H2NCH2CH2 (C?O); ?-amino-acyl; R5=alkyl, especially methyl, phenyl. The invention also relates to the use of said compound for producing compounds of the 5-sulfanyl-histidine type and the derivatives thereof, in addition to corresponding disulfides; and to the various methods for the production thereof.

Abstract: The invention relates to a compound of the 5-acylsulfanyl-histidine type and the derivatives thereof, of general formula (I), wherein R1 to R3=H, alkyl, especially CH3; R4=H, alkyl, especially CH3, alkyle(C=0), substituted alkyl (C?O), aryl (C?O); ?-alanyl (H2NCH2CH2 (C?O); ?-amino-acyl; R5=alkyl, especially methyl, phenyl. The invention also relates to the use of said compound for producing compounds of the 5-sulfanyl-histidine type and the derivatives thereof, in addition to corresponding disulfides; and to the various methods for the production thereof.

Abstract: The invention relates to a method for the purification of L-hercynine. Said method for the purification of L-hercynine, from a reaction mixture resulting from the reaction of L-histidine, in controlled pH conditions, with a methylating agent Me X in a polar solvent or a mixture of polar solvents, at room temperature, is characterised in that it comprises at least one step of separating the organic products from the inorganic salts formed during the reaction by electrodialysis. This method allows the L-hercynine losses to be limited during the purification.

Abstract: The invention relates to a compound of the 5-acylsulfanyl-histidine type and the derivatives thereof, of general formula (I), wherein R1 to R3=H, alkyl, especially CH3; R4=H, alkyl, especially CH3, alkyle(C?O), substituted alkyl (C?O), aryl (C?O); ?-alanyl (H2NCH2CH2 (C?O); ?-amino-acyl; R5=alkyl, especially methyl, phenyl. The invention also relates to the use of said compound for producing compounds of the 5-sulfanyl-histidine type and the derivatives thereof, in addition to corresponding disulfides; and to the various methods for the production thereof.

Abstract: The invention relates to a selenium compound. Said selenium compound has formula (I), where R1=alkyl; R2=H, R4C(=0), R4OC(=0), a-aminoacyl, CH3SeCH2CH2CH(NH2)C(=0), CH3SeCH2CH2CH(OH)C(=0); X=OH, OR3, NH2, NR4R5, ?-amino acid, CH3SeCH2CH2CH(COOH)NH—, CH3SeCH2CH2CH(COOH)0-; R3=alkyl; R4=alkyl, aryl; R5=H, alkyl, aryl; R4 and R5 which can together form a 5- or 6-membered cycloalkyl radical which can comprise a heteroatom; provided that when X=NH-terbutyl, R2?C(=0)CH3. Said compound can be used as a pharmaceutical substance, in particular as an antitumour substance.

Abstract: Methods for the synthesis of 2-thiohistidine or a derivative thereof of the formula (I), or of a physiologically acceptable salt, a tautomer, a stereoisomer or a mixture of stereoisomers in any proportions thereof, from a compound of the formula (II) or a physiologically acceptable salt, a tautomer, a stereoisomer or a mixture of stereoisomers in any proportions thereof, by cleavage reaction in the presence of a thiol at a temperature higher than or equal to 60° C. The invention also relates to compounds of the formula (II) and a method for the synthesis thereof.

Abstract: The present disclosure relates to a method for synthesizing ergothioneine or one of the derivatives thereof of following formula (I): or a physiologically acceptable salt, a tautomer, a stereoisomer or a mixture of stereoisomers in all proportions thereof, from a compound of betaine type of following formula (II): or a physiologically acceptable salt, a tautomer, a stereoisomer or a mixture of stereoisomers in all proportions thereof, by cleavage reaction in the presence of a thiol, at a temperature above or equal to 60° C. The present disclosure also relates to compounds of formula (II) and the method of synthesis thereof.

Abstract: Methods for the synthesis of 2-thiohistidine or a derivative thereof of the formula (I), or of a physiologically acceptable salt, a tautomer, a stereoisomer or a mixture of stereoisomers in any proportions thereof, from a compound of the formula (II) or a physiologically acceptable salt, a tautomer, a stereoisomer or a mixture of stereoisomers in any proportions thereof, by cleavage reaction in the presence of a thiol at a temperature higher than or equal to 60° C. The invention also relates to compounds of the formula (II) and a method for the synthesis thereof.

Abstract: The present invention relates to a novel process for preparing 2-hydroxy-4-methylselenobutyric acid from 3-methylselenoproprion-aldehyde. The 2-hydroxy-4-methylselenobutyric acid is obtained alone or as a mixture with its sulphur-containing analogue. The invention also relates to the compositions, in particular nutritional compositions, comprising a mixture of 2-hydroxy-4-methylselenobutyric acid and 2-hydroxy-4-methylthiobutyric acid, and a physiologically acceptable medium, and to the use of this mixture as a dietary ingredient.

Abstract: The present disclosure relates to a method for synthesizing ergothioneine or one of the derivatives thereof of following formula (I): or a physiologically acceptable salt, a tautomer, a stereoisomer or a mixture of stereoisomers in all proportions thereof, from a compound of betaine type of following formula (II): or a physiologically acceptable salt, a tautomer, a stereoisomer or a mixture of stereoisomers in all proportions thereof, by cleavage reaction in the presence of a thiol, at a temperature above or equal to 60° C. The present disclosure also relates to compounds of formula (II) and the method of synthesis thereof.

Abstract: The present invention relates to a novel process for preparing 2-hydroxy-4-methylselenobutyric acid from 3-methylselenoproprion-aldehyde. The 2-hydroxy-4-methylselenobutyric acid is obtained alone or as a mixture with its sulphur-containing analogue. The invention also relates to the compositions, in particular nutritional compositions, comprising a mixture of 2-hydroxy-4-methylselenobutyric acid and 2-hydroxy-4-methylthiobutyric acid, and a physiologically acceptable medium, and to the use of this mixture as a dietary ingredient.

Abstract: Compounds corresponding to the following general formula (I): are formulated into pharmaceutical compositions useful in human or veterinary medicine or else into cosmetic compositions; novel compounds of formula (II) are also thus useful:

Abstract: A composition, suitable for topical application to the skin, containing at least one benzoisothiazolone of formula (I): Novel benzoisothiazolones of formula (I) and a method of caring for dry and/or mature skin.

Abstract: A composition, suitable for topical application to the skin, containing at least one benzoisothiazolone of formula (I): Novel benzoisothiazolones of formula (I) and a method of caring for dry and/or mature skin.

Abstract: The present invention relates to novel heterocyclic derivatives of 2-oxothiazolidine-4-carboxylic acid, to a process for synthesizing them and to compositions containing them. The invention also relates to the use of at least one heterocyclic derivative of 2-oxathiazolidine-4-carboxylic acid in a composition or for the manufacture of a composition, the said derivative or the said composition being intended to induce active photoprotection of the skin, advantageously to prepare the skin to receive sunlight and/or to protect the skin and other epidermal growths during or after exposure to UV. Another subject of the invention also relates to a cosmetic process for treating the skin by oral administration or topical administration to the skin of a cosmetic composition as defined above.

Abstract: The present invention relates to novel heterocyclic derivatives of 2-oxothiazolidine-4-carboxylic acid, to a process for synthesizing them and to compositions containing them. The invention also relates to the use of at least one heterocyclic derivative of 2-oxathiazolidine-4-carboxylic acid in a composition or for the manufacture of a composition, the said derivative or the said composition being intended to induce active photoprotection of the skin, advantageously to prepare the skin to receive sunlight and/or to protect the skin and other epidermal growths during or after exposure to UV. Another subject of the invention also relates to a cosmetic process for treating the skin by oral administration or topical administration to the skin of a cosmetic composition as defined above.