Abstract: The combination of skin-contacted stimulation together with capillary blood flow monitoring is applied in a tandem, coordinated fashion in an integrated system and method to provide early detection of compromised circulation conditions, to provide data useful for prescribing therapeutic treatments including stimulation therapies, and to monitor the effectiveness of various treatments. The disclosed methods and system can apply to a broad spectrum of diagnosed and/or undiagnosed vascular diseases and extend to detection and treatment of limb or appendage injury. An integrated device which can be a portable or a wearable product which makes use of the new system and method is disclosed.

Abstract: The combination of skin-contacted stimulation together with capillary blood flow monitoring is applied in a tandem, coordinated fashion in an integrated system and method to provide early detection of compromised circulation conditions, to provide data useful for prescribing therapeutic treatments including stimulation therapies, and to monitor the effectiveness of various treatments. The disclosed methods and system can apply to a broad spectrum of diagnosed and/or undiagnosed vascular diseases and extend to detection and treatment of limb or appendage injury. An integrated device which can be a portable or a wearable product which makes use of the new system and method is disclosed.

Abstract: The present invention provides a hydrophilic inclusion complex consisting essentially of nanosized particles of an active compound in amorphous form and an amphiphilic polymer which wraps the active compound such that non-valent bonds are formed between the active compound and the amphiphilic polymer. The invention further provides hydrophilic dispersions comprising said inclusion complexes, particularly of pharmaceutical drugs, and stable pharmaceutical compositions comprising said dispersions of the pharmaceutical drugs in amorphous form.