Patents by Inventor Irene Sinn
Irene Sinn has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240094203Abstract: A device for determining presence or absence of infection due to an infectious agent is described. The device comprises a sample receiving zone configured to receive a liquid sample from a subject suspected of having an infection due to an infectious agent, the sample receiving zone positioned to distribute the sample along a first fluid flow path to a first label zone and along a second fluid flow path to a second label zone. Test lines in each fluid flow path capture a mobile detectable species as an indicator of presence or absence of the infectious agent. The device also comprises a reference line positioned in the one of the fluid flow paths. The bidirectional fluid flow paths emanate from a common sample zone and provide an efficient approach to detection and differentiate two species as indicators of the same infectious agent or as indicators of two different infectious agents.Type: ApplicationFiled: November 8, 2023Publication date: March 21, 2024Inventors: Robert Reed, Irene Sinn-Blandy, Robert Weiller, Jason McClure
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Patent number: 11846637Abstract: A device for determining presence or absence of infection due to an infectious agent is described. The device comprises a sample receiving zone configured to receive a liquid sample from a subject suspected of having an infection due to an infectious agent, the sample receiving zone positioned to distribute the sample along a first fluid flow path to a first label zone and along a second fluid flow path to a second label zone. Test lines in each fluid flow path capture a mobile detectable species as an indicator of presence or absence of the infectious agent. The device also comprises a reference line positioned in the one of the fluid flow paths. The bidirectional fluid flow paths emanate from a common sample zone and provide an efficient approach to detection and differentiate two species as indicators of the same infectious agent or as indicators of two different infectious agents.Type: GrantFiled: August 24, 2021Date of Patent: December 19, 2023Assignee: Quidel CorporationInventors: Robert Reed, Irene Sinn-Blandy, Robert Weiller, Jason McClure
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Publication number: 20230243809Abstract: Separation of the cellular components of whole blood, or other biological fluid, from plasma or serum can be achieved for assay analysis. A device for facilitating separation can include, for example, a capillary tube that accurately draws target blood volume, a pad that chemically interacts with red-blood cells, such that the red blood cells become chemically and/or physically trapped within pad material, a mechanism for plasma recovery from the pad upon diffusion or active mixing, and a dropper tip that facilitates dispensing the mixture onto a test device. The treatment of the cellular components can be performed prior to contact with a buffer solution, so release of the cellular components into the buffer solution is reduced or prevented. Additional filtration can be provided to filter any remaining cellular components in the mixture.Type: ApplicationFiled: April 10, 2023Publication date: August 3, 2023Inventors: Irene Sinn Blandy, Rayna Thiesen, Scott Alexander Fall, Robert Reed, Robert Weiller
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Patent number: 11650200Abstract: Separation of the cellular components of whole blood, or other biological fluid, from plasma or serum can be achieved for assay analysis. A device for facilitating separation can include, for example, a capillary tube that accurately draws target blood volume, a pad that chemically interacts with red-blood cells, such that the red blood cells become chemically and/or physically trapped within pad material, a mechanism for plasma recovery from the pad upon diffusion or active mixing, and a dropper tip that facilitates dispensing the mixture onto a test device. The treatment of the cellular components can be performed prior to contact with a buffer solution, so release of the cellular components into the buffer solution is reduced or prevented. Additional filtration can be provided to filter any remaining cellular components in the mixture.Type: GrantFiled: December 30, 2020Date of Patent: May 16, 2023Assignee: Quidel CorporationInventors: Irene Sinn Blandy, Rayna Thiesen, Scott Alexander Fall, Robert Reed, Robert Weiller
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Patent number: 11446654Abstract: A substrate structured to define thereon a fluid flow channel and/or a fluid control feature is described. The substrate may additionally comprise a capture zone and/or a test zone, for use as a test strip for determining presence or absence of an analyte of interest, such as an infectious agent or a biomarker. Reagents are deposited in the capture zone and/or test zone as an array of drops.Type: GrantFiled: February 9, 2018Date of Patent: September 20, 2022Assignee: Quidel CorporationInventors: Samantha Chang, Jason McClure, Robert Reed, Irene Sinn Blandy, Robert Weiller, Christian Bobritchi
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Publication number: 20220184605Abstract: A substrate structured to define thereon a fluid flow channel and/or a fluid control feature is described. The substrate may additionally comprise a capture zone and/or a test zone, for use as a test strip for determining presence or absence of an analyte of interest, such as an infectious agent or a biomarker. Reagents are deposited in the capture zone and/or test zone as an array of drops.Type: ApplicationFiled: March 4, 2022Publication date: June 16, 2022Inventors: Samantha Chang, Jason McClure, Robert Reed, Irene Sinn Blandy, Robert Weiller, Christian Bobritchi
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Publication number: 20210396752Abstract: A device for determining presence or absence of infection due to an infectious agent is described. The device comprises a sample receiving zone configured to receive a liquid sample from a subject suspected of having an infection due to an infectious agent, the sample receiving zone positioned to distribute the sample along a first fluid flow path to a first label zone and along a second fluid flow path to a second label zone. Test lines in each fluid flow path capture a mobile detectable species as an indicator of presence or absence of the infectious agent. The device also comprises a reference line positioned in the one of the fluid flow paths. The bidirectional fluid flow paths emanate from a common sample zone and provide an efficient approach to detection and differentiate two species as indicators of the same infectious agent or as indicators of two different infectious agents.Type: ApplicationFiled: August 24, 2021Publication date: December 23, 2021Inventors: Robert Reed, Irene Sinn-Blandy, Robert Weiller, Jason McClure
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Patent number: 11131670Abstract: A device for determining presence or absence of infection due to an infectious agent is described. The device comprises a sample receiving zone configured to receive a liquid sample from a subject suspected of having an infection due to an infectious agent, the sample receiving zone positioned to distribute the sample along a first fluid flow path to a first label zone and along a second fluid flow path to a second label zone. Test lines in each fluid flow path capture a mobile detectable species as an indicator of presence or absence of the infectious agent. The device also comprises a reference line positioned in the one of the fluid flow paths. The bidirectional fluid flow paths emanate from a common sample zone and provide an efficient approach to detection and differentiate two species as indicators of the same infectious agent or as indicators of two different infectious agents.Type: GrantFiled: August 25, 2016Date of Patent: September 28, 2021Assignee: Quidel CorporationInventors: Robert Reed, Irene Sinn, Robert Weiller, Jason McClure
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Publication number: 20210255178Abstract: Immunoassay devices with plurality of fluid flow channels that are discrete and designed for optimal fluid control are described. Substrates configured to control the rate of fluid flow for in-situ immunoassay measurements to detect and quantify the presence of one or more analytes of interest in a sample are also described. More specifically, the present disclosure relates to consumables for lateral flow assays, which in conjunction with an instrument detect markers or causative agents of medical conditions.Type: ApplicationFiled: January 8, 2021Publication date: August 19, 2021Inventors: Samantha CHANG, Irene Sinn BLANDY, Robert REED, Cristina CHARLES, Lauren HEDGES
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Publication number: 20210215715Abstract: Methods and kits for diagnosis of confirmatory diagnosis of a tick-borne infection, such as Lyme disease, is provided. The methods and kits include one or more multi-channel lateral flow immunoassay test strips. In an embodiment, the test strip comprises at least five individual, discrete fluid flow channels where each of the at least five channels includes one or more binding members (antigens) for detection of immunoglobulin antibodies against a Borrelia bacterium in a blood sample. The binding members (antigens) are, in one embodiment, selected from a group of immunoglobulin antibodies consisting of p18 (decorin-binding protein), p23, p28, p30, p39, p41 (flagellin), p45, p58, p66, p93, VlSE/C6 and p31. The kits include external controls selected from a container with a positive control, a container with a negative control, and both of a container with a positive control and a container with a negative control.Type: ApplicationFiled: January 8, 2021Publication date: July 15, 2021Inventors: Samantha Chang, Irene Sinn Blandy, Robert Reed, Cristina Charles, Lauren Hedges, Ashlee King
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Publication number: 20210116438Abstract: Separation of the cellular components of whole blood, or other biological fluid, from plasma or serum can be achieved for assay analysis. A device for facilitating separation can include, for example, a capillary tube that accurately draws target blood volume, a pad that chemically interacts with red-blood cells, such that the red blood cells become chemically and/or physically trapped within pad material, a mechanism for plasma recovery from the pad upon diffusion or active mixing, and a dropper tip that facilitates dispensing the mixture onto a test device. The treatment of the cellular components can be performed prior to contact with a buffer solution, so release of the cellular components into the buffer solution is reduced or prevented. Additional filtration can be provided to filter any remaining cellular components in the mixture.Type: ApplicationFiled: December 30, 2020Publication date: April 22, 2021Inventors: Irene Sinn Blandy, Rayna Thiesen, Scott Alexander Fall, Robert Reed, Robert Weiller
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Patent number: 10908145Abstract: Separation of the cellular components of whole blood, or other biological fluid, from plasma or serum can be achieved for assay analysis. A device for facilitating separation can include, for example, a capillary tube that accurately draws target blood volume, a pad that chemically interacts with red-blood cells, such that the red blood cells become chemically and/or physically trapped within pad material, a mechanism for plasma recovery from the pad upon diffusion or active mixing, and a dropper tip that facilitates dispensing the mixture onto a test device. The treatment of the cellular components can be performed prior to contact with a buffer solution, so release of the cellular components into the buffer solution is reduced or prevented. Additional filtration can be provided to filter any remaining cellular components in the mixture.Type: GrantFiled: November 16, 2017Date of Patent: February 2, 2021Assignee: Quidel CorporationInventors: Irene Sinn Blandy, Rayna Thiesen, Scott Alexander Fall, Robert Reed, Robert Weiller
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Publication number: 20180229232Abstract: A substrate structured to define thereon a fluid flow channel and/or a fluid control feature is described. The substrate may additionally comprise a capture zone and/or a test zone, for use as a test strip for determining presence or absence of an analyte of interest, such as an infectious agent or a biomarker. Reagents are deposited in the capture zone and/or test zone as an array of drops.Type: ApplicationFiled: February 9, 2018Publication date: August 16, 2018Inventors: Samantha Chang, Jason McClure, Robert Reed, Irene Sinn Blandy, Robert Weiller, Christian Bobritchi
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Publication number: 20180136194Abstract: Separation of the cellular components of whole blood, or other biological fluid, from plasma or serum can be achieved for assay analysis. A device for facilitating separation can include, for example, a capillary tube that accurately draws target blood volume, a pad that chemically interacts with red-blood cells, such that the red blood cells become chemically and/or physically trapped within pad material, a mechanism for plasma recovery from the pad upon diffusion or active mixing, and a dropper tip that facilitates dispensing the mixture onto a test device. The treatment of the cellular components can be performed prior to contact with a buffer solution, so release of the cellular components into the buffer solution is reduced or prevented. Additional filtration can be provided to filter any remaining cellular components in the mixture.Type: ApplicationFiled: November 16, 2017Publication date: May 17, 2018Inventors: Irene Sinn Blandy, Rayna Thiesen, Scott Alexander Fall, Robert Reed, Robert Weiller
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Publication number: 20170059566Abstract: A device for determining presence or absence of infection due to an infectious agent is described. The device comprises a sample receiving zone configured to receive a liquid sample from a subject suspected of having an infection due to an infectious agent, the sample receiving zone positioned to distribute the sample along a first fluid flow path to a first label zone and along a second fluid flow path to a second label zone. Test lines in each fluid flow path capture a mobile detectable species as an indicator of presence or absence of the infectious agent. The device also comprises a reference line positioned in the one of the fluid flow paths. The bidirectional fluid flow paths emanate from a common sample zone and provide an efficient approach to detection and differentiate two species as indicators of the same infectious agent or as indicators of two different infectious agents.Type: ApplicationFiled: August 25, 2016Publication date: March 2, 2017Inventors: Robert Reed, Irene Sinn, Robert Weiller, Jason McClure
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Patent number: 8846331Abstract: Described herein are various methods, devices and systems for performing asynchronous magnetic bead rotation (AMBR) to detect and monitor cellular growth and/or behavior. Cluster rotation of magnetic particles for AMBR is descried. In particular, described herein are systems for the parallel analysis of multiple wells of a sample plate. Also described herein are methods for controlling the illumination and imaging of rotating magnetic particles.Type: GrantFiled: August 29, 2011Date of Patent: September 30, 2014Assignee: The Regents of the University of MichiganInventors: Brandon H. McNaughton, Paivo Kinnunen, Raoul Kopelman, Alan Hunt, Roy Clarke, Irene Sinn, Remy Elbez, Theodore Albertson
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Publication number: 20120164680Abstract: Described herein are various methods, devices and systems for performing asynchronous magnetic bead rotation (AMBR) to detect and monitor cellular growth and/or behavior. Cluster rotation of magnetic particles for AMBR is descried. In particular, described herein are systems for the parallel analysis of multiple wells of a sample plate. Also described herein are methods for controlling the illumination and imaging of rotating magnetic particles.Type: ApplicationFiled: August 29, 2011Publication date: June 28, 2012Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGANInventors: Brandon H. McNaughton, Paivo Kinnunen, Raoul Kopelman, Alan Hunt, Roy Clarke, Irene Sinn, Remy Elbez, Theodore Albertson