Patents by Inventor Irene Stirling
Irene Stirling has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 4652560Abstract: The compounds of the formula (II): ##STR1## or pharmaceutically acceptable salts or esters thereof wherein A is a hydrogen atom or an esterifying radical; X is an alkyl group of 1-12 carbon atoms optionally substituted by a hydroxy, amino, acylamino of C.sub.1-6 alkoxy group, which substituents are not on the carbon atom adjacent to the nitrogen atom; or a C.sub.5-7 cycloalkyl group; or a phenylalkyl group wherein the carbon atom content of the alkyl part is 1-6 and the phenyl part is optionally substituted with a fluorine, bromine, chlorine, C.sub.1-6 alkyl, or C.sub.1-6 alkoxy; with the proviso that when X represents an optionally substituted phenylalkyl group and A represents C.sub.1-3 alkyl, then the --CO.sub.2 A group is attached to the alkyl part of the phenylalkyl group; have been found to be .beta.-lactamase inhibitors and antibacterial agents. Their preparation and use is described.Type: GrantFiled: April 13, 1983Date of Patent: March 24, 1987Assignee: Beecham Group p.l.c.Inventors: Brian P. Clarke, John B. Harbridge, Irene Stirling
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Patent number: 4562182Abstract: A compound of formula (I) or a salt or ester thereof: ##STR1## Pharmaceutical compositions comprising a compound of formula (I) or a pharmaceutically acceptable salt or pharmaceutically acceptable ester thereof are also disclosed.Type: GrantFiled: December 8, 1981Date of Patent: December 31, 1985Assignee: Beecham Group p.l.c.Inventors: John B. Harbridge, Irene Stirling
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Patent number: 4539202Abstract: The compounds of the formula (II): ##STR1## or pharmaceutically acceptable salts or esters thereof wherein A is a hydrogen atom or an esterifying radical; X is an alkyl group of 1-12 carbon atoms optionally substituted by a hydroxy, amino, acylamino of C.sub.1-6 alkoxy group, which substituents are not on the carbon atom adjacent to the nitrogen atom; or a C.sub.5-7 cycloalkyl group; or a phenylalkyl group wherein the carbon atom content of the alkyl part is 1-6 and the phenyl part is optionally substituted with a fluorine, bromine, chlorine, C.sub.1-6 alkyl, or C.sub.1-6 alkoxy; with the proviso that when X represents an optionally substituted phenylalkyl group and A represents C.sub.1-3 alkyl, then the --CO.sub.2 A group is attached to the alkyl part of the phenylalkyl group; have been found to be .beta.-lactamase inhibitors and antibacterial agents. Their preparation and use is described.Type: GrantFiled: March 24, 1983Date of Patent: September 3, 1985Assignee: Beecham Group p.l.c.Inventors: Brian P. Clarke, John B. Harbridge, Irene Stirling
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Patent number: 4524073Abstract: A compound of formula (I) or a pharmaceutically acceptable salt or in vivo hydrolysable ester thereof: ##STR1## wherein R represents an alkyl or aralkyl group, substituted on an alkyl carbon atom other than that adjacent to --NH-- group, with one or more functional groups selected from halogen, non-aromatic heterocyclyl linked through carbon, aromatic heterocyclyl, nitro, oxo, --OR.sup.1, SR.sup.1 --P(O)R.sup.2 R.sup.3, --NR.sup.4 R.sup.5, .dbd.NR.sup.6, or a sulphur linked organic radical, wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5 and R.sup.6 are various organic radicals.Processes for the preparation of these compounds and pharmaceutical compositions containing them are also disclosed.Type: GrantFiled: July 20, 1983Date of Patent: June 18, 1985Assignee: Beecham Group p.1.c.Inventors: Irene Stirling, Gordon Bruton, Stephen H. Calvert, Brian P. Clarke
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Patent number: 4444754Abstract: The compounds of the formula (I): ##STR1## and esters thereof wherein R.sub.1 is a lower alkyl group or a phenyl group and R.sub.2 is a hydrogen atom or R.sub.2 together with R.sub.1 represents the residue of a fused benzene ring are .beta.-lactamase inhibitors and anti-bacterial agents. Their preparation and use is described.Type: GrantFiled: March 10, 1981Date of Patent: April 24, 1984Assignee: Beecham Group LimitedInventors: Irene Stirling, Brian P. Clarke
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Patent number: 4435565Abstract: Secondary amines of clavulanic acid are useful as beta-lactamase inhibitors that enhance the effectiveness of penicillins or cephalosphorins and also have antibacterial properties in their own right.Type: GrantFiled: March 16, 1981Date of Patent: March 6, 1984Assignee: Beecham Group LimitedInventors: Irene Stirling, Brian P. Clarke
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Patent number: 4426389Abstract: The compounds of the formula (II): ##STR1## pharmaceutically acceptable salts thereof, esters thereof and acid addition salts thereof wherein X is a C.sub.1-6 alkylene group, a C.sub.3-8 cycloalkylene group or a C.sub.3-8 cycloalkyl C.sub.1-4 alkylene group, have been found to be .beta.-lactamase inhibitors and antibacterial agents. Their preparation and use is described.Type: GrantFiled: September 22, 1980Date of Patent: January 17, 1984Assignee: Beecham Group LimitedInventors: Irene Stirling, Brian P. Clarke
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Patent number: 4359473Abstract: The compounds of the formula (XVII) ##STR1## and their esters wherein R.sub.2 is a hydrogen, fluorine, chlorine or bromine atom or an alkyl group of 1-3 carbon atoms, an alkoxyl group of 1-3 carbon atoms, an acyloxyl group of 1-3 atoms, a hydroxyl group, an alkoxycarbonyl group containing 1-3 carbon atoms in the alkoxy part, or a group --N(R.sub.5)CO.R.sub.6, --N(R.sub.5)SO.sub.2 R.sub.6 or --CO-NR.sub.5 R.sub.6 where R.sub.5 is a hydrogen atom or an alkyl group of 1-3 carbon atoms or a phenyl or benzyl group and R.sub.6 is an alkyl group of 1-3 carbon atoms or a phenyl or benzyl group; R.sub.3 is a hydrogen, fluorine or chlorine atom or an alkyl group of 1-3 carbon atoms, an alkoxyl group of 1-3 carbon atoms; or an acyloxyl group of 1-3 carbon atoms R.sub.4 is a hydrogen fluorine or chlorine atom or an alkyl group of 1-3 atoms or an alkoxyl group of 1-3 carbon atoms; and X is a bond or alkylene group of 1-4 carbon atoms; have been found to be .beta.-lactamase inhibitors and antibacterial agents.Type: GrantFiled: September 4, 1979Date of Patent: November 16, 1982Assignee: Beecham Group LimitedInventors: Irene Stirling, Brian P. Clarke
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Patent number: 4354974Abstract: Esters of the compound of the formula: ##STR1## are useful for their antibacterial and .beta.-lactamase inhibitory activity.Type: GrantFiled: December 6, 1976Date of Patent: October 19, 1982Assignee: Beecham Group LimitedInventor: Irene Stirling
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Patent number: 4343807Abstract: The compounds of the formula (II): ##STR1## and pharmaceutically acceptable salts and esters thereof wherein X is a C.sub.1-6 alkylene group; m is 1, 2 or 3; n is 1, 2 or 3; A is oxygen, sulphur, --CH.sub.2 -- or --NR.sup.3 -- wherein R.sup.3 is hydrogen, C.sub.1-6 alkyl, phenyl or phenyl (C.sub.1-6)alkyl; R.sup.1 is hydrogen, oxo, C.sub.1-6 alkyl, C.sub.1-6 alkoxy, hydroxy or phenyl; and R.sup.2 is hydrogen, oxo, C.sub.1-6 alkyl or phenyl: with the proviso that if m and n are both 1 then A is --CH.sub.2 -- and R.sup.2 is not oxo: have been found to be .beta.-lactamase inhibitors and antibacterial agents. Their preparation and use are described.Type: GrantFiled: September 24, 1980Date of Patent: August 10, 1982Assignee: Beecham Group LimitedInventors: Irene Stirling, Brian P. Clarke
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Patent number: 4301168Abstract: The compounds of the formula (I): ##STR1## and esters thereof wherein R.sub.1 is a lower alkyl group or a phenyl group and R.sub.2 is a hydrogen atom or R.sub.2 together with R.sub.1 represents the residue of a fused benzene ring are .beta.-lactamase inhibitors and anti-bacterial agents. Their preparation and use is described.Type: GrantFiled: August 22, 1979Date of Patent: November 17, 1981Assignee: Beecham Group LimitedInventors: Irene Stirling, Brian P. Clarke
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Patent number: 4242262Abstract: The present invention provides the compound of the formula (II): ##STR1## and salts and esters thereof.Type: GrantFiled: November 20, 1978Date of Patent: December 30, 1980Assignee: Beecham Group LimitedInventor: Irene Stirling
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Patent number: 4132712Abstract: Compounds of the formula ##STR1## wherein CO.sub.2 R is an ester group, are useful for their .beta.-lactamase inhibitory activity.Type: GrantFiled: August 26, 1976Date of Patent: January 2, 1979Assignee: Beecham Group LimitedInventors: Thomas T. Howarth, Irene Stirling, David F. Corbett
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Patent number: 4088656Abstract: The compound of the formula (II): ##STR1## and its pharmaceutically acceptable salts and esters may be produced by ozonolysis of clavulanic acid and its derivatives. The compound has antibacterial and .beta.-lactamase inhibiting activity.Type: GrantFiled: November 26, 1976Date of Patent: May 9, 1978Assignee: Beecham Group LimitedInventors: Thomas T. Howarth, Irene Stirling
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Patent number: 4073786Abstract: Novel pteridines of formula (I), ##STR1## wherein R is a lower alkyl group, optionally substituted with a hydroxy group and R.sup.1 and R.sup.2 are the same or different and each is a lower alkyl group having together at least 3 carbon atoms or R.sup.1 and R.sup.2, together with the carbon atom in the pteridine ring structure, form a spirocycloalkyl ring system having 4 to 6 carbon atoms outside the pteridine ring structure, and their method of preparation.The above compounds have bacteriostatic activity.Type: GrantFiled: July 31, 1975Date of Patent: February 14, 1978Assignee: Burroughs Wellcome Co.Inventors: Hamish C. S. Wood, Irene Stirling
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Patent number: 4036969Abstract: Compounds of the formula ##STR1## wherein R is methyl, ethyl, trifluoromethyl, methoxy, ethoxy, nitro, hydrogen or halogen, andX is hydroxy or hydrogen,Are useful as .beta.-lactamase inhibitors.Type: GrantFiled: June 11, 1976Date of Patent: July 19, 1977Assignee: Beecham Group LimitedInventor: Irene Stirling
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Patent number: 3963719Abstract: Novel pteridines of formula (I), ##SPC1##wherein R is a lower alkyl group, optionally substituted with a hydroxy group and R.sup.1 and R.sup.2 are the same or different and each is a lower alkyl group having together at least 3 carbon atoms or R.sup.1 and R.sup.2, together with the carbon atom in the pteridine ring structure, form a spirocycloalkyl ring system having 4 to 6 carbon atoms outside the pteridine ring structure, and their method of preparation.The above compounds have bacteriostatic activity.Type: GrantFiled: July 30, 1973Date of Patent: June 15, 1976Assignee: Burroughs Wellcome Co.Inventors: Hamish Christopher Swan Wood, Irene Stirling