Abstract: A pharmaceutical composition having antialcoholic activity, stimulating energy metabolism and acid-forming and secretory functions of stomach mucosa, having radioprotective and anticholera activities contains a mixture of succinic acid and citric acid or pharmaceutically acceptable salts thereof as an active ingredient.A method for preventing and treating alcohol intoxication and alcohol abstinence syndrome, stimulating energy metabolism stimulating and diagnosing acid-forming and secretory functions of stomach mucosa, protecting against radiation damage and preventing cholera which comprises oral administration of an effective amount of the present composition.

Abstract: A granulated composition for direct tableting, comprising non-pressed or difficulty pressed, water-soluble, crystalline pharmaceutical substances, binder, lubricant and water, contains at least 98 wt. % of a pharmaceutically active component. The tablets manufactured from said composition have high hardness and the controllable time of dissolution. A method for preparing said composition consists in that the powder of a pharmaceutical substance is pre-granulated with water or its aqueous solution, the resultant granulate is then subjected to subsequent granulation with a binder solution, dried and powdered with lubricant.