Patents by Inventor Irina Aizman

Irina Aizman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and compositions for stimulation of cell proliferation and provision of biologically active mixtures of FGF2 isoforms
    Patent number: 11406685
    Abstract: Disclosed herein are methods and compositions for providing mixtures of FGF2 isoforms that are biologically active. The biological activities include, but are not limited to, stimulation of proliferation of neural precursor cells, stimulation of proliferation of endothelial cells, stimulation of development of neural precursor cells, and stimulation of development of astrocytes.
    Type: Grant
    Filed: June 12, 2019
    Date of Patent: August 9, 2022
    Assignee: SanBio, Inc.
    Inventors: Irina Aizman, Damien Bates
  • MSC growth predictor assays
    Patent number: 11124771
    Abstract: Methods for selecting lots of bone marrow stromal cells (MSCs) having a high proliferative capacity are provided. Such methods are useful in the manufacture of therapeutic derivatives of MSCs.
    Type: Grant
    Filed: December 17, 2018
    Date of Patent: September 21, 2021
    Assignee: SanBio, Inc.
    Inventor: Irina Aizman
  • Extracellular matrix from pluripotent cells
    Patent number: 10702554
    Abstract: Isolated extracellular matrix from marrow adherent stromal cells and their descendents, which stimulates the growth and survival of a number of different neural cell types, is provided, along with methods for preparation and uses.
    Type: Grant
    Filed: December 3, 2008
    Date of Patent: July 7, 2020
    Assignee: SanBio, Inc.
    Inventor: Irina Aizman
  • Extracellular matrix from pluripotent cells
    Patent number: 10653724
    Abstract: Isolated extracellular matrix from marrow adherent stromal cells and their descendents, which stimulates the growth and survival of a number of different neural cell types, is provided, along with methods for preparation and uses.
    Type: Grant
    Filed: January 12, 2018
    Date of Patent: May 19, 2020
    Assignee: SanBio, Inc.
    Inventor: Irina Aizman
  • Extracellular matrix from pluripotent cells
    Patent number: 10471102
    Abstract: Isolated extracellular matrix from marrow adherent stromal cells and their descendents, which stimulates the growth and survival of a number of different neural cell types, is provided, along with methods for preparation and uses.
    Type: Grant
    Filed: April 4, 2018
    Date of Patent: November 12, 2019
    Assignee: SanBio, Inc.
    Inventor: Irina Aizman
  • METHODS AND COMPOSITIONS FOR STIMULATION OF CELL PROLIFERATION AND PROVISION OF BIOLOGICALLY ACTIVE MIXTURES OF FGF2 ISOFORMS
    Publication number: 20190290730
    Abstract: Disclosed herein are methods and compositions for providing mixtures of FGF2 isoforms that are biologically active. The biological activities include, but are not limited to, stimulation of proliferation of neural precursor cells, stimulation of proliferation of endothelial cells, stimulation of development of neural precursor cells, and stimulation of development of astrocytes.
    Type: Application
    Filed: June 12, 2019
    Publication date: September 26, 2019
    Applicant: SanBio, Inc.
    Inventors: Irina AIZMAN, Damien BATES
  • NEUROGENIC AND GLIOGENIC FACTORS AND ASSAYS THEREFOR
    Publication number: 20190285614
    Abstract: Disclosed herein are quantitative assays for measuring the potential of a substance, or a source of a substance, to promote neurogenesis and gliogenesis. Substances that promote neurogenesis and gliogenesis are also disclosed.
    Type: Application
    Filed: May 8, 2019
    Publication date: September 19, 2019
    Applicant: SanBio, Inc.
    Inventors: Irina AIZMAN, Casey C. CASE
  • Methods and compositions for stimulation of cell proliferation and provision of biologically active mixtures of FGF2 isoforms
    Patent number: 10363285
    Abstract: Disclosed herein are methods and compositions for providing mixtures of FGF2 isoforms that are biologically active. The biological activities include, but are not limited to, stimulation of proliferation of neural precursor cells, stimulation of proliferation of endothelial cells, stimulation of development of neural precursor cells, and stimulation of development of astrocytes.
    Type: Grant
    Filed: September 20, 2017
    Date of Patent: July 30, 2019
    Assignee: SanBio, Inc.
    Inventors: Irina Aizman, Damien Bates
  • METHODS AND COMPOSITIONS FOR PROVISION OF ANGIOGENIC FACTORS
    Publication number: 20190224247
    Abstract: Disclosed herein are methods and compositions for the use of marrow adherent stem cells and their descendents; e.g., bone marrow-derived neural regenerating cells; for provision of angiogenic factors to cells. In certain embodiments, provision of angiogenic factors to sites of neural degeneration stimulates growth and/or survival of host neurons.
    Type: Application
    Filed: April 3, 2019
    Publication date: July 25, 2019
    Applicant: SanBio, Inc.
    Inventors: Keita MORI, Martha C. BOHN, Ciara TATE, Irina AIZMAN, Aleksandra GLAVASKI, Tamas VIRAG
  • MSC GROWTH PREDICTOR ASSAYS
    Publication number: 20190127701
    Abstract: Methods for selecting lots of bone marrow stromal cells (MSCs) having a high proliferative capacity are provided. Such methods are useful in the manufacture of therapeutic derivatives of MSCs.
    Type: Application
    Filed: December 17, 2018
    Publication date: May 2, 2019
    Applicant: SanBio, Inc.
    Inventor: Irina AIZMAN
  • EXTRACELLULAR MATRIX FROM PLURIPOTENT CELLS
    Publication number: 20180221414
    Abstract: Isolated extracellular matrix from marrow adherent stromal cells and their descendents, which stimulates the growth and survival of a number of different neural cell types, is provided, along with methods for preparation and uses.
    Type: Application
    Filed: April 4, 2018
    Publication date: August 9, 2018
    Applicant: SanBio, Inc.
    Inventor: Irina AIZMAN
  • EXTRACELLULAR MATRIX FROM PLURIPOTENT CELLS
    Publication number: 20180140636
    Abstract: Isolated extracellular matrix from marrow adherent stromal cells and their descendents, which stimulates the growth and survival of a number of different neural cell types, is provided, along with methods for preparation and uses.
    Type: Application
    Filed: January 12, 2018
    Publication date: May 24, 2018
    Applicant: SanBio, Inc.
    Inventor: Irina AIZMAN
  • METHODS AND COMPOSITIONS FOR STIMULATION OF CELL PROLIFERATION AND PROVISION OF BIOLOGICALLY ACTIVE MIXTURES OF FGF2 ISOFORMS
    Publication number: 20180036378
    Abstract: Disclosed herein are methods and compositions for providing mixtures of FGF2 isoforms that are biologically active. The biological activities include, but are not limited to, stimulation of proliferation of neural precursor cells, stimulation of proliferation of endothelial cells, stimulation of development of neural precursor cells, and stimulation of development of astrocytes.
    Type: Application
    Filed: September 20, 2017
    Publication date: February 8, 2018
    Applicant: SanBio, Inc.
    Inventors: Irina AIZMAN, Damien BATES
  • METHODS AND COMPOSITIONS FOR PROVISION OF ANGIOGENIC FACTORS
    Publication number: 20150104435
    Abstract: Disclosed herein are methods and compositions for the use of marrow adherent stem cells and their descendents; e.g., bone marrow-derived neural regenerating cells; for provision of angiogenic factors to cells. In certain embodiments, provision of angiogenic factors to sites of neural degeneration stimulates growth and/or survival of host neurons.
    Type: Application
    Filed: December 16, 2014
    Publication date: April 16, 2015
    Inventors: Keita Mori, Martha C. Bohn, Ciara Tate, Irina Aizman, Aleksandra Glavaski, Tamas Virag
  • Methods and composition for treating neural degeneration
    Patent number: 8945919
    Abstract: Disclosed herein are methods and compositions for the use of marrow adherent stem cells and their descendents; e.g., bone marrow-derived neural regenerating cells; in the treatment of various neurodegenerative disorders. In certain embodiments, bone marrow-derived neural regenerating cells transplanted to sites of neural degeneration stimulate growth and/or survival of host neurons.
    Type: Grant
    Filed: August 14, 2008
    Date of Patent: February 3, 2015
    Assignee: San Bio, Inc.
    Inventors: Keita Mori, Martha C. Bohn, Ciara Tate, Irina Aizman, Aleksandra Glavaski, Tamas Virag
  • EXTRACELLULAR MATRIX FROM PLURIPOTENT CELLS
    Publication number: 20140363408
    Abstract: Isolated extracellular matrix from marrow adherent stromal cells and their descendents, which stimulates the growth and survival of a number of different neural cell types, is provided, along with methods for preparation and uses.
    Type: Application
    Filed: August 21, 2014
    Publication date: December 11, 2014
    Inventor: Irina Aizman
  • NEUROGENIC AND GLIOGENIC FACTORS AND ASSAYS THEREFOR
    Publication number: 20130210000
    Abstract: Disclosed herein are quantitative assays for measuring the potential of a substance, or a source of a substance, to promote neurogenesis and gliogenesis. Substances that promote neurogenesis and gliogenesis are also disclosed.
    Type: Application
    Filed: August 20, 2012
    Publication date: August 15, 2013
    Inventors: Irina Aizman, Casey C. Case
  • METHODS AND COMPOSITIONS FOR MODULATING DIFFERENTIATION OF PLURIPOTENTIAL CELLS
    Publication number: 20110306137
    Abstract: Methods and compositions useful for altering the differentiation potential of marrow adherent stromal cells, also known as mesenchymal stem cells are disclosed. The normal tendency for these cells to differentiate into osteogenic and adipogenic lineages is restricted.
    Type: Application
    Filed: December 3, 2008
    Publication date: December 15, 2011
    Inventor: Irina Aizman
  • EXTRACELLULAR MATRIX FROM PLURIPOTENT CELLS
    Publication number: 20100310529
    Abstract: Isolated extracellular matrix from marrow adherent stromal cells and their descendents, which stimulates the growth and survival of a number of different neural cell types, is provided, along with methods for preparation and uses.
    Type: Application
    Filed: December 3, 2008
    Publication date: December 9, 2010
    Inventor: Irina Aizman
  • METHODS AND COMPOSITION FOR TREATING NEURAL DEGENERATION
    Publication number: 20100266554
    Abstract: Disclosed herein are methods and compositions for the use of marrow adherent stem cells and their descendents; e.g., bone marrow-derived neural regenerating cells; in the treatment of various neurodegenerative disorders. In certain embodiments, bone marrow-derived neural regenerating cells transplanted to sites of neural degeneration stimulate growth and/or survival of host neurons.
    Type: Application
    Filed: August 14, 2008
    Publication date: October 21, 2010
    Inventors: Keita Mori, Martha C. Bohn, Ciara Tate, Irina Aizman, Aleksandra Glavaski, Tamas Virag