Patents by Inventor Irina Astafieva
Irina Astafieva has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8658194Abstract: A segmented polyurethane and an amphiphilic random or block copolymer are disclosed. The segmented polyurethane and the amphiphilic random or block copolymer can be used for fabricating a coating for an implantable medical device such as a stent.Type: GrantFiled: October 21, 2010Date of Patent: February 25, 2014Assignee: Advanced Cardiovascular Systems, Inc.Inventors: Thierry Glauser, Connie S. Kwok, Charles D. Claude, Eugene T. Michal, Yiwen Tang, Irina Astafieva, John Whatley, Stephen D. Pacetti, Ashok Shah
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Patent number: 8383592Abstract: A method including advancing a delivery device through a lumen of a blood vessel to a particular region in the blood vessel; and introducing a synthetic apolipoprotein A-1 (Apo A-I) mimetic peptide into a wall of the blood vessel at the particular region, wherein the peptide has a property that renders the peptide effective in reverse cholesterol transport. A composition including a synthetic apolipoprotein A-I (Apo A-I) mimetic peptide, or combination of an Apo A-I synthetic peptide and an Acyl CoA cholesterol: acyltransferase (ACAT) inhibitor in a form suitable for delivery into a blood vessel, the peptide including an amino acid sequence in an order reverse to an order of an endogenous Apo A-I related peptide. A composition including an apolipoprotein A-1 (Apo A-I) synthetic peptide in a form suitable for delivery into a blood vessel, the peptide including an amino acid backbone that has less amino acid residues relative to endogenous Apo A-I and a chimera of helix 1 and helix 9 of Apo A-I.Type: GrantFiled: July 6, 2011Date of Patent: February 26, 2013Assignee: Abbott Cardiovascular Systems Inc.Inventors: Katsuyuki Murase, Li Zhao, Irina Astafieva, Paul M. Consigny
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Patent number: 8309112Abstract: A segmented polyurethane and an amphiphilic random or block copolymer are disclosed. The segmented polyurethane and the amphiphilic random or block copolymer can be used for fabricating a coating for an implantable medical device such as a stent.Type: GrantFiled: December 24, 2003Date of Patent: November 13, 2012Assignee: Advanced Cardiovascular Systems, Inc.Inventors: Thierry Glauser, Connie S. Kwok, Charles D. Claude, Eugene T. Michal, Yiwen Tang, Irina Astafieva, John Whatley, Stephen D. Pacetti, Ashok Shah
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Patent number: 8101565Abstract: A method including advancing a delivery device through a lumen of a blood vessel to a particular region in the blood vessel; and introducing a composition including a sustained-release carrier and an apolipoprotein A-I (apo A-I) synthetic mimetic peptide into a wall of the blood vessel at the particular region or a perivascular site, wherein the peptide has a property that renders the peptide effective in reverse cholesterol transport. A composition including an apolipoprotein A-I (apo A-I) synthetic peptide, or combination of an apo A-I synthetic mimetic peptide and an Acyl CoA cholesterol: acyltransferase (ACAT) inhibitor in a form suitable for delivery into a blood vessel, the peptide including an amino acid sequence in an order reverse to an order of various apo A-I mimetic peptides, or endogenous apo A-I analogs, or a chimera of helix 1 and helix 9 of endogenous apo A-I.Type: GrantFiled: November 27, 2007Date of Patent: January 24, 2012Assignee: Abbott Cardiovascular Systems Inc.Inventors: Katsuyuki Murase, Syed F. A. Hossainy, Irina Astafieva, Li Zhao, Hong Ma
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Publication number: 20110263497Abstract: A method including advancing a delivery device through a lumen of a blood vessel to a particular region in the blood vessel; and introducing a synthetic apolipoprotein A-1 (Apo A-I) mimetic peptide into a wall of the blood vessel at the particular region, wherein the peptide has a property that renders the peptide effective in reverse cholesterol transport. A composition including a synthetic apolipoprotein A-I (Apo A-I) mimetic peptide, or combination of an Apo A-I synthetic peptide and an Acyl CoA cholesterol: acyltransferase (ACAT) inhibitor in a form suitable for delivery into a blood vessel, the peptide including an amino acid sequence in an order reverse to an order of an endogenous Apo A-I related peptide. A composition including an apolipoprotein A-1 (Apo A-I) synthetic peptide in a form suitable for delivery into a blood vessel, the peptide including an amino acid backbone that has less amino acid residues relative to endogenous Apo A-I and a chimera of helix 1 and helix 9 of Apo A-I.Type: ApplicationFiled: July 6, 2011Publication date: October 27, 2011Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC.Inventors: Katsuyuki Murase, Li Zhao, Irina Astafieva, Paul M. Consigny
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Publication number: 20110262530Abstract: A method including advancing a delivery device through a lumen of a blood vessel to a particular region in the blood vessel; and introducing a composition including a sustained-release carrier and an apolipoprotein A-I (Apo A-I) synthetic mimetic peptide into a wall of the blood vessel at the particular region, wherein the peptide has a property that renders the peptide effective in reverse cholesterol transport. A composition including an apolipoprotein A-I (Apo A-I) synthetic peptide, or combination of an Apo A-I synthetic mimetic peptide and an Acyl CoA cholesterol: acyltransferase (ACAT) inhibitor in a form suitable for delivery into a blood vessel, the peptide including an amino acid sequence in an order reverse to an order of various Apo A-I mimetic peptides, or endogenous Apo A-I analogs, or a chimera of helix 1 and helix 9 of endogenous Apo A-I.Type: ApplicationFiled: July 6, 2011Publication date: October 27, 2011Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC.Inventors: KATSUYUKI MURASE, LI ZHAO, IRINA ASTAFIEVA, PAUL M. CONSIGNY, STEPHEN D. PACETTI, DARIUSH DAVALIAN, SYED FAYAIZ AHMED HOSSAINY, FLORIAN N. LUDWIG, JINPING WAN, JOHN STANKUS, RACHEL BRIGHT
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Publication number: 20110184384Abstract: This invention relates to methods of enhancing the permeability of blood vessels to therapeutic agents.Type: ApplicationFiled: April 4, 2011Publication date: July 28, 2011Applicant: Abbott Cardiovascular Systems Inc.Inventors: Dariush Davalian, Stephen Pacetti, Florian Niklas Ludwig, Syed Faiyaz Ahmed Hossainy, Irina Astafieva, Kimchi Tran
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Patent number: 7985727Abstract: A method including advancing a delivery device through a lumen of a blood vessel to a particular region in the blood vessel; and introducing a synthetic apolipoprotein A-1 (Apo A-I) mimetic peptide into a wall of the blood vessel at the particular region, wherein the peptide has a property that renders the peptide effective in reverse cholesterol transport. A composition including a synthetic apolipoprotein A-I (Apo A-I) mimetic peptide, or combination of an Apo A-I synthetic peptide and an Acyl CoA cholesterol: acyltransferase (ACAT) inhibitor in a form suitable for delivery into a blood vessel, the peptide including an amino acid sequence in an order reverse to an order of an endogenous Apo A-I related peptide. A composition including an apolipoprotein A-1 (Apo A-I) synthetic peptide in a form suitable for delivery into a blood vessel, the peptide including an amino acid backbone that has less amino acid residues relative to endogenous Apo A-I and a chimera of helix 1 and helix 9 of Apo A-I.Type: GrantFiled: September 20, 2007Date of Patent: July 26, 2011Assignee: Abbott Cardiovascular Systems Inc.Inventors: Katsuyuki Murase, Li Zhao, Irina Astafieva, Paul M. Consigny
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Patent number: 7985728Abstract: A method including advancing a delivery device through a lumen of a blood vessel to a particular region in the blood vessel; and introducing a composition including a sustained-release carrier and an apolipoprotein A-I (Apo A-I) synthetic mimetic peptide into a wall of the blood vessel at the particular region, wherein the peptide has a property that renders the peptide effective in reverse cholesterol transport. A composition including an apolipoprotein A-I (Apo A-I) synthetic peptide, or combination of an Apo A-I synthetic mimetic peptide and an Acyl CoA cholesterol: acyltransferase (ACAT) inhibitor in a form suitable for delivery into a blood vessel, the peptide including an amino acid sequence in an order reverse to an order of various Apo A-I mimetic peptides, or endogenous Apo A-I analogs, or a chimera of helix 1 and helix 9 of endogenous Apo A-I.Type: GrantFiled: September 20, 2007Date of Patent: July 26, 2011Assignee: Abbott Cardiovascular Systems Inc.Inventors: Katsuyuki Murase, Li Zhao, Irina Astafieva, Paul M. Consigny, Stephen D. Pacetti, Dariush Davalian, Syed Fayaiz Ahmed Hossainy, Florian N. Ludwig, Jinping Wan, John Stankus, Rachel Bright
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Patent number: 7977465Abstract: The present invention provides analogues of duocarmycins that are potent cytotoxins. Also provided are peptidyl and disulfide linkers that are cleaved in vivo. The linkers are of use in forming prodrugs and conjugates of the cytotoxins of the invention as well as other diagnostic and therapeutic moieties. The invention provides prodrugs and conjugates of the duocarmycin analogues with the linker arms of the invention.Type: GrantFiled: March 4, 2009Date of Patent: July 12, 2011Assignee: Medarex, Inc.Inventors: Howard P. Ng, Danny P. C. McGee, Guoxian Wu, Jimmie Moore, Zhi-Hong Li, Sanjeev Gangwar, Oliver L. Saunders, Irina Astafieva
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Publication number: 20110033517Abstract: A segmented polyurethane and an amphiphilic random or block copolymer are disclosed. The segmented polyurethane and the amphiphilic random or block copolymer can be used for fabricating a coating for an implantable medical device such as a stent.Type: ApplicationFiled: October 21, 2010Publication date: February 10, 2011Inventors: Thierry Glauser, Connie S. Kwok, Charles D. Claude, Eugene T. Michal, Yiwen Tang, Irina Astafieva, John Whatley, Stephen D. Pacetti, Ashok Shah
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Publication number: 20110027188Abstract: An implantable medical device is disclosed having a plurality of smaller particles contained in a plurality of larger particles and configured to be released from the larger particles when the device is implanted in a patient. The smaller particles and the larger particles are made of bioabsorbable metal, glass or ceramic. A substance can be associated with the smaller particles. The larger particles can be embedded within at least a portion of the device.Type: ApplicationFiled: October 8, 2010Publication date: February 3, 2011Applicant: Advanced Cardiovascular Systems, Inc.Inventors: Lothar W. Kleiner, Syed Hossainy, Irina Astafieva, Stephen Pacetti, Thierry Glauser, Jessica DesNoyer, Florian N. Ludwig
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Patent number: 7795467Abstract: Bioabsorbable, polyurethane-based stent coatings that comprise non-fouling coatings with polyethylene glycol and hyaluronic acid are disclosed. In addition to these coatings, medical devices comprising these coatings and methods of applying the coatings are disclosed.Type: GrantFiled: April 26, 2005Date of Patent: September 14, 2010Assignee: Advanced Cardiovascular Systems, Inc.Inventors: Stephen Dirk Pacetti, Charles Claude, Irina Astafieva
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Publication number: 20100222872Abstract: Methods and compositions for the sustained release of treatment agents to treat an occluded blood vessel and affected tissue and/or organs are disclosed. Porous or non-porous bioabsorbable glass, metal or ceramic bead, rod or fiber particles can be loaded with a treatment agent, and optionally an image-enhancing agent, and coated with a sustained-release coating for delivery to an occluded blood vessel and affected tissue and/or organs by a delivery device. Implantable medical devices manufactured with coatings including the particles or embedded within the medical device are additionally disclosed.Type: ApplicationFiled: May 18, 2010Publication date: September 2, 2010Applicant: Advanced Cardiovascular Systems, Inc.Inventors: Lothar W. Kleiner, Syed Hossainy, Irina Astafieva, Stephen Pacetti, Thierry Glauser, Jessica Desnoyer, Florian N. Ludwig
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Publication number: 20100104653Abstract: Nanoparticle-coated medical devices, nanoparticle-containing formulations and methods of using for treating a vascular disease are disclosed. The method for treating a vascular disease includes providing a formulation comprising a plurality of nanoparticles having a density different from that of blood and further comprising one or more bioactive agents encapsulated within, adhered to a surface of or integrated into the structure of the nanoparticles; and administering a therapeutically effective amount of the formulation to a vascular disease locale in a patient.Type: ApplicationFiled: January 5, 2010Publication date: April 29, 2010Applicant: Abbott Cardiovascular Systems Inc.Inventors: Florian Niklas Ludwig, Syed Faiyaz Ahmed Hossainy, Katsuyuki Murase, Li Zhao, Irina Astafieva
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Publication number: 20100104506Abstract: Nanoparticle-coated medical devices, nanoparticle-containing formulations and methods of using for treating a vascular disease are disclosed. The medical device includes a coating that comprises a plurality of nanoparticles, wherein the nanoparticles comprise one or more bioactive agents encapsulated within, adhered to a surface of or integrated into the structure of the nanoparticles and further comprise one or more contrast enhancing agents encapsulated within, adhered to a surface of or integrated into the structure of the nanoparticles.Type: ApplicationFiled: January 5, 2010Publication date: April 29, 2010Applicant: Abbott Cardiovascular Systems Inc.Inventors: Florian Niklas Ludwig, Syed Faiyaz Ahmed Hossainy, Katsuyuki Murase, Li Zhao, Irina Astafieva
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Publication number: 20090258028Abstract: This invention is generally related to methods of forming coatings for implantable medical devices, such as drug delivery vascular stents. The methods are for forming coatings to control the release of a peptide such as RGD, and a hydrophobic drug. Both single layer and multiple layer coating constructs are encompassed in the various embodiments of the present invention.Type: ApplicationFiled: April 15, 2009Publication date: October 15, 2009Applicant: Abbott Cardiovascular Systems Inc.Inventors: Thierry Glauser, Syed F.A. Hossainy, Irina Astafieva, Florencia Lim, Xinmin Xu, Bozena Z. Maslanka, Mikael O. Trollsas, Michael H. Ngo
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Publication number: 20090209734Abstract: The present invention provides analogues of duocarmycins that are potent cytotoxins. Also provided are peptidyl and disulfide linkers that are cleaved in vivo. The linkers are of use in forming prodrugs and conjugates of the cytotoxins of the invention as well as other diagnostic and therapeutic moieties. The invention provides prodrugs and conjugates of the duocarmycin analogues with the linker arms of the invention.Type: ApplicationFiled: March 4, 2009Publication date: August 20, 2009Applicant: Medarex, Inc.Inventors: Howard P. Ng, Danny P.C. McGee, Guoxian Wu, Jimmie Moore, Zhihong Li, Sanjeev Gangwar, Oliver L. Saunders, Irina Astafieva
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Publication number: 20090081298Abstract: A method including advancing a delivery device through a lumen of a blood vessel to a particular region in the blood vessel; and introducing a composition including a sustained-release carrier and an apolipoprotein A-I (apo A-I) synthetic mimetic peptide into a wall of the blood vessel at the particular region or a perivascular site, wherein the peptide has a property that renders the peptide effective in reverse cholesterol transport. A composition including an apolipoprotein A-I (apo A-I) synthetic peptide, or combination of an apo A-I synthetic mimetic peptide and an Acyl CoA cholesterol: acyltransferase (ACAT) inhibitor in a form suitable for delivery into a blood vessel, the peptide including an amino acid sequence in an order reverse to an order of various apo A-I mimetic peptides, or endogenous apo A-I analogs, or a chimera of helix 1 and helix 9 of endogenous apo A-I.Type: ApplicationFiled: November 27, 2007Publication date: March 26, 2009Inventors: Katsuyuki Murase, Syed F. A. Hossainy, Irina Astafieva, Li Zhao, Hong Ma
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Patent number: RE41252Abstract: The present invention provides analogues of duocarmycins that are potent cytotoxins. Also provided are peptidyl and disulfide linkers that are cleaved in vivo. The linkers are of use in forming prodrugs and conjugates of the cytotoxins of the invention as well as other diagnostic and therapeutic moieties. The invention provides prodrugs and conjugates of the duocarmycin analogues with the linker arms of the invention.Type: GrantFiled: May 23, 2008Date of Patent: April 20, 2010Assignee: Medarex, Inc.Inventors: Howard P. Ng, Danny P. C. McGee, Guoxian Wu, Jimmie Moore, Zhi-Hong Li, Sanjeev Gangwar, Oliver L. Saunder, Irina Astafieva, Valeri Martichonok