Patents by Inventor Irina C. Jacobson

Irina C. Jacobson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • INHIBITORS OF HEPATITIS C VIRUS POLYMERASE
    Publication number: 20140322165
    Abstract: The present invention provides, among other things, compounds represented by the general Formula I: and pharmaceutically acceptable salts thereof, wherein X, Y, R1A, R1B, R2, and R3 are as defined in classes and subclasses herein and compositions (e.g., pharmaceutical compositions) comprising such compounds, which compounds are useful as inhibitors of hepatitis C virus polymerase, and thus are useful, for example, as medicaments for the treatment of HCV infection.
    Type: Application
    Filed: July 8, 2014
    Publication date: October 30, 2014
    Inventors: Sam SK Lee, Wang Shen, Xiaoling Zheng, Irina C. Jacobson
  • Inhibitors of hepatitis C virus polymerase
    Patent number: 8771665
    Abstract: The present invention provides, among other things, compounds represented by the general Formula I: and pharmaceutically acceptable salts thereof, wherein X, Y, R1A, R1B, R2, and R3 are as defined in classes and subclasses herein and compositions (e.g., pharmaceutical compositions) comprising such compounds, which compounds are useful as inhibitors of hepatitis C virus polymerase, and thus are useful, for example, as medicaments for the treatment of HCV infection.
    Type: Grant
    Filed: December 16, 2011
    Date of Patent: July 8, 2014
    Assignee: Cocrystal Discovery, Inc.
    Inventors: Sam S K Lee, Wang Shen, Xiaoling Zheng, Irina C. Jacobson
  • INHIBITORS OF HEPATITIS C VIRUS POLYMERASE
    Publication number: 20120183496
    Abstract: The present invention provides, among other things, compounds represented by the general Formula I: and pharmaceutically acceptable salts thereof, wherein X, Y, R1A, R1B, R2, and R3 are as defined in classes and subclasses herein and compositions (e.g., pharmaceutical compositions) comprising such compounds, which compounds are useful as inhibitors of hepatitis C virus polymerase, and thus are useful, for example, as medicaments for the treatment of HCV infection.
    Type: Application
    Filed: December 16, 2011
    Publication date: July 19, 2012
    Applicant: COCRYSTAL DISCOVERY, INC.
    Inventors: Sam SK Lee, Wang Shen, Xiaoling Zheng, Irina C. Jacobson
  • Monocyclic or bicyclic carbocycles and heterocycles as factor Xa inhibitors
    Patent number: 6951872
    Abstract: The present application describes monocyclic or bicyclic carbocycles and heterocycles and derivatives thereof of Formula I: or pharmaceutically acceptable salt forms thereof, which are useful as inhibitors of factor Xa.
    Type: Grant
    Filed: December 8, 2003
    Date of Patent: October 4, 2005
    Assignee: Bristol-Myers Squibb Pharma Company
    Inventors: Irina C. Jacobson, Ruth R. Wexler, Suanne Nakajima, Mimi L. Quan, Shuaige Wang, Joanne M. Smallheer, Jennifer Qiao
  • Bicyclic inhibitors of factor Xa
    Patent number: 6878710
    Abstract: This invention relates generally to a novel class of bicyclic heterocyclic compounds of the Formula (I): or pharmaceutically acceptable salt forms thereof, which are inhibitors of trypsin-like serine protease enzymes, especially factor Xa, pharmaceutical compositions containing the same, and methods of using the same as anticoagulant agents for treatment and prevention of thromboembolic disorders.
    Type: Grant
    Filed: May 22, 2002
    Date of Patent: April 12, 2005
    Assignee: Bristol-Myers Squibb Pharma Company
    Inventors: Irina C. Jacobson, Mimi L. Quan, Yun-Long Li, Ruth R. Wexler, Patrick Y. S. Lam
  • Fused heterocyclic inhibitors of factor Xa
    Patent number: 6790845
    Abstract: This invention relates generally to a novel class of fused heterocyclic compounds of the Formula (I) or Formula (II): or pharmaceutically acceptable salt forms thereof, which are inhibitors of trypsin-like serine protease enzymes, especially factor Xa, pharmaceutical compositions containing the same, and methods of using the same as anticoagulant agents for treatment and prevention of thromboembolic disorders.
    Type: Grant
    Filed: April 8, 2002
    Date of Patent: September 14, 2004
    Assignee: Bristol-Myers Squibb Pharma Company
    Inventors: Irina C. Jacobson, Mimi L. Quan, Ruth R. Wexler
  • Monocyclic or bicyclic carbocycles and heterocycles as factor Xa inhibitors
    Publication number: 20040132718
    Abstract: The present application describes monocyclic or bicyclic carbocycles and heterocycles and derivatives thereof of Formula I: 1
    Type: Application
    Filed: December 8, 2003
    Publication date: July 8, 2004
    Inventors: Irina C. Jacobson, Ruth R. Wexler, Suanne Nakajima, Mimi L. Quan, Shuaige Wang, Joanne M. Smallheer, Jennifer X. Qiao
  • Nitrogen containing heterobicycles as factor Xa inhibitors
    Patent number: 6716841
    Abstract: This invention relates generally to nitrogen containing heterobicycles of formulas A and B: which are inhibitors of trypsin-like serine protease enzymes, especially factor Xa, pharmaceutical compositions containing the same, and methods of using the same as anticoagulant agents for treatment and prevention of thromboembolic disorders.
    Type: Grant
    Filed: July 26, 2002
    Date of Patent: April 6, 2004
    Assignee: Bristol-Myers Squibb Pharma Company
    Inventors: Irina C. Jacobson, Mimi L. Quan
  • Monocyclic or bicyclic carbocycles and heterocycles as factor Xa inhibitors
    Patent number: 6710058
    Abstract: The present application describes monocyclic or bicyclic carbocycles and heterocycles and derivatives thereof of Formula I: or pharmaceutically acceptable salt forms thereof, which are useful as inhibitors of factor Xa.
    Type: Grant
    Filed: October 29, 2001
    Date of Patent: March 23, 2004
    Assignee: Bristol-Myers Squibb Pharma Company
    Inventors: Irina C. Jacobson, Ruth R. Wexler, Shuaige Wang, Joanne M. Smallheer
  • Aryl sulfonyls as factor Xa inhibitors
    Patent number: 6689770
    Abstract: The present application describes aryl sulfonyls of formula I: or pharmaceutically acceptable salt or prodrug forms thereof, wherein D, E, and M are defined below, are effective factor Xa inhibitors.
    Type: Grant
    Filed: February 12, 2002
    Date of Patent: February 10, 2004
    Assignee: Bristol-Myers Squibb Pharma Company
    Inventors: Ruth R. Wexler, Irina C. Jacobson
  • Thrombin or factor Xa inhibitors
    Patent number: 6602871
    Abstract: This invention relates generally to inhibitors of trypsin-like serine protease enzymes, especially factor Xa or thrombin, pharmaceutical compositions containing the same, and methods of using the same as anticoagulant agents for treatment and prevention of thromboembolic disorders.
    Type: Grant
    Filed: December 4, 2001
    Date of Patent: August 5, 2003
    Assignee: Bristol-Myers Squibb Pharma Company
    Inventors: Patrick Y. S. Lam, Charles G. Clark, John M. Fevig, Robert A. Galemmo, Qi Han, Irina C. Jacobson, Renhau Li, Donald J. P. Pinto, Ruth R. Wexler
  • Nitrogen containing heterobicycles as factor Xa inhibitors
    Publication number: 20030096820
    Abstract: This invention relates generally to nitrogen containing heterobicycles of formulas A and B: 1
    Type: Application
    Filed: July 26, 2002
    Publication date: May 22, 2003
    Inventors: Irina C. Jacobson, Mimi L. Quan
  • Bicyclic inhibitors of factor Xa
    Publication number: 20030096804
    Abstract: This invention relates generally to a novel class of bicyclic heterocyclic compounds of the Formula (I): 1
    Type: Application
    Filed: May 22, 2002
    Publication date: May 22, 2003
    Inventors: Irina C. Jacobson, Mimi L. Quan, Yun-Long Li, Ruth R. Wexler, Patrick Y.S. Lam
  • Fused heterocyclic inhibitors of factor Xa
    Publication number: 20030087909
    Abstract: This invention relates generally to a novel class of fused heterocyclic compounds of the Formula (I) or Formula (II): 1
    Type: Application
    Filed: April 8, 2002
    Publication date: May 8, 2003
    Inventors: Irina C. Jacobson, Mimi L. Quan, Ruth R. Wexler
  • Aryl sulfonyls as factor Xa inhibitors
    Publication number: 20030050315
    Abstract: The present application describes aryl sulfonyls of formula I: 1
    Type: Application
    Filed: February 12, 2002
    Publication date: March 13, 2003
    Inventors: Ruth R. Wexler, Irina C. Jacobson
  • Monocyclic or bicyclic carbocycles and heterocycles as factor Xa inhibitors
    Publication number: 20020183324
    Abstract: The present application describes monocyclic or bicyclic carbocycles and heterocycles and derivatives thereof of Formula I: 1
    Type: Application
    Filed: October 29, 2001
    Publication date: December 5, 2002
    Inventors: Irina C. Jacobson, Ruth R. Wexler, Suanne Nakajima, Mimi L. Quan, Shuaige Wang, Joanne M. Smallheer, Jennifer Qiao
  • Thrombin or factor Xa inhibitors
    Publication number: 20020115854
    Abstract: This invention relates generally to inhibitors of trypsin-like serine protease enzymes, especially factor Xa or thrombin, pharmaceutical compositions containing the same, and methods of using the same as anticoagulant agents for treatment and prevention of thromboembolic disorders.
    Type: Application
    Filed: December 4, 2001
    Publication date: August 22, 2002
    Inventors: Patrick Y.S. Lam, Charles G. Clark, John M. Fevig, Robert A. Galemmo, Qi Han, Irina C. Jacobson, Renhau Li, Donald J.P. Pinto, Ruth R. Wexler
  • Nitrogen containing heterobicycles as factor Xa inhibitors
    Patent number: 6429205
    Abstract: This invention relates generally to nitrogen containing heterobicycles of formulas A and B: which are inhibitors of trypsin-like serine protease enzymes, especially factor Xa, pharmaceutical compositions containing the same, and methods of using the same as anticoagulant agents for treatment and prevention of thromboembolic disorders.
    Type: Grant
    Filed: July 13, 2000
    Date of Patent: August 6, 2002
    Assignee: Bristol-Meyers Squibb Pharma Company
    Inventors: Irina C. Jacobson, Mimi L. Quan
  • Thrombin or factor Xa inhibitors
    Patent number: 6403583
    Abstract: This invention relates generally to inhibitors of trypsin-like serine protease enzymes, especially factor Xa or thrombin, pharmaceutical compositions containing the same, and methods of using the same as anticoagulant agents for treatment and prevention of thromboembolic disorders.
    Type: Grant
    Filed: December 22, 1999
    Date of Patent: June 11, 2002
    Inventors: Patrick Y. S. Lam, Charles G. Clark, John M. Fevig, Robert A. Galemmo, Qi Han, Irina C. Jacobson, Renhau Li, Donald J. P. Pinto, Ruth R. Wexler
  • Aryl sulfonyls as factor XA inhibitors
    Patent number: 6399644
    Abstract: The present application describes aryl sulfonyls of formula I: or pharmaceutically acceptable salt or prodrug forms thereof, wherein D, E, and M are defined below, are effective factor Xa inhibitors.
    Type: Grant
    Filed: March 31, 2000
    Date of Patent: June 4, 2002
    Inventors: Ruth R. Wexler, Irina C. Jacobson