Patents by Inventor Irina Gribun

Irina Gribun has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Use of purified donepezil maleate for preparing pharmaceutically pure amorphous donepezil hydrochloride
    Patent number: 7592459
    Abstract: The present invention provides a crystalline donepezil maleate, which is used as an intermediate in the preparation of donepezil hydrochloride. Also provided are novel processes for producing same in substantially pure form and a process for producing pharmaceutically pure amorphous donepezil hydrochloride therefrom.
    Type: Grant
    Filed: September 27, 2005
    Date of Patent: September 22, 2009
    Assignee: Chemagis Ltd.
    Inventors: Oded Arad, Lior Zelikovitch, Mohammed Alnabari, Michael Brand, Irina Gribun, Ada Salman, Meital Shiffer, Moty Shookrun, Orna Kurlat, Moshe Bentolila, Joseph Kaspi
  • Process for the manufacture of aripiprazole by using purified carbostyril compounds such as 7-(4-halobutoxy)-3,4-dihydro-2(1H)-quinolinones
    Publication number: 20070213535
    Abstract: The present invention provides a process for purifying carbostyril derivatives such as 7-(4-bromobutoxy)-3,4-dihydro-2(1H)-quinolinone and 7-(4-chlorobutoxy)-3,4-dihydro-2(1H)-quinolinone and aripiprazole by passing a solution of the material in an organic solvent through a suitable absorbing material.
    Type: Application
    Filed: March 7, 2007
    Publication date: September 13, 2007
    Applicant: Chemagis Ltd.
    Inventors: Michael Brand, Irina Gribun, Oded Arad, Joseph Kaspi
  • Methods of preparing a crystalline form of 7-(4-chlorobutoxy)-3,4-dihydro-2(1h)-quinolinone and the use thereof in the synthesis of Aripiprazole
    Publication number: 20070149782
    Abstract: The present invention relates to methods of preparing a highly pure crystalline form of 7-(4-chlorobutoxy)-3,4-dihydro-2(1H)-quinolinone, which is a chemical intermediate useful in the preparation of Aripiprazole thereof in high quality and yield, and provides data that characterizes the crystalline form of 7-(4-chlorobutoxy)-3,4-dihydro-(1H)-quinolinone.
    Type: Application
    Filed: December 23, 2005
    Publication date: June 28, 2007
    Inventors: Michael Brand, Moty Shookrun, Irina Gribun, Itai Adin, Carmen Iustain, Oleg Braverman, Natalia Udis, Oded Arad, Joseph Kaspi
  • Crystalline aripiprazole salts and processes for preparation and purification thereof
    Publication number: 20060223820
    Abstract: Provided are novel crystalline carboxylic acid salts of aripiprazole, methods of using such salts, and processes for producing such salts.
    Type: Application
    Filed: March 21, 2006
    Publication date: October 5, 2006
    Applicant: CHEMAGIS LTD.
    Inventors: Michael Brand, Moti Shookrun, Irina Gribun, Itai Adin, Carmen Iustain, Oded Arad, Joseph Kaspi
  • Processes for preparing and purifying carbostyril compounds such as aripiprazole and 7-(4-halobutoxy)-3,4-dihydro-2(1H)-quinolinones
    Publication number: 20060079689
    Abstract: The present invention provides several improved processes for preparing aripiprazole, wherein the first step comprising reacting 7-HQ with a 1,4-disubstituted-butane in biphasic reaction mixture or in a single phase solvent to obtain a 7-(4-halobutoxy)-3,4-dihydro-(1H)-quinolinone (7-HBQ) and the second step comprising reacting the 7-HBQ and 1-(2,3-dichlorophenyl)piperazine or an acid addition salt thereof in a biphasic reaction medium containing water and a water-immiscible solvent to obtain aripiprazole. Also provided are methods of purifying the 7-HBQs and aripiprazole.
    Type: Application
    Filed: October 11, 2005
    Publication date: April 13, 2006
    Inventors: Vladimir Naddaka, Michael Brand, Guy Davidi, Eyal Klopfer, Irina Gribun, Oded Arad, Joseph Kaspi
  • Process for the reduction of (S)-2-amino-6-propionamido-4,5,6,7-tetrahydrobenzo-thiazole
    Publication number: 20060069263
    Abstract: A process is disclosed for the reduction of (S)-2-amino-6-propionamido-4,5,6,7-tetrahydrobenzothiazole, which comprises reacting (S)-2-amino-6-propionamido-4,5,6,7-tetrahydrobenzothiazole with a borane reagent in the presence of suitable organic solvent to yield (S)-2-amino-6-propylamino-4,5,6,7-tetrahydrobenzothiazole base, which may be converted to an acid addition salt thereof. The process provided herein can be easily, conveniently and inexpensively scaled-up.
    Type: Application
    Filed: September 23, 2005
    Publication date: March 30, 2006
    Inventors: Irina Gribun, Ada Salman, Meital Shiffer, Moty Shookrun, Michael Brand, Oded Arad, Joseph Kaspi
  • Use of purified donepezil maleate for preparing pharmaceutically pure amorphous donepezil hydrochloride
    Publication number: 20060069125
    Abstract: The present invention provides a crystalline donepezil maleate, which is used as an intermediate in the preparation of donepezil hydrochloride. Also provided are novel processes for producing same in substantially pure form and a process for producing pharmaceutically pure amorphous donepezil hydrochloride therefrom.
    Type: Application
    Filed: September 27, 2005
    Publication date: March 30, 2006
    Inventors: Oded Arad, Lior Zelikovitch, Mohammed Alnabari, Michael Brand, Irina Gribun, Ada Salman, Meital Shiffer, Moty Shookrun, Orna Kurlat, Moshe Bentolila, Joseph Kaspi