Patents by Inventor Irina Klimanskaya

Irina Klimanskaya has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MODALITIES FOR THE TREATMENT OF DEGENERATIVE DISEASES OF THE RETINA
    Publication number: 20240131077
    Abstract: This invention relates to methods for improved cell-based therapies for retinal degeneration and for differentiating human embryonic stem cells and human embryo-derived into retinal pigment epithelium (RPE) cells and other retinal progenitor cells.
    Type: Application
    Filed: September 20, 2023
    Publication date: April 25, 2024
    Applicant: Astellas Institute for Regenerative Medicine
    Inventors: Irina Klimanskaya, Robert P. Lanza
  • METHODS FOR DETECTION OF RARE SUBPOPULATIONS OF CELLS AND HIGHLY PURIFIED COMPOSITION OF CELLS
    Publication number: 20240026419
    Abstract: Methods are provided for detection of a target cell type within a cell population, and compositions are provided comprising cells and an indicator that indicates the number of cells of the target cell type in the cell population. Examples are provided in which these methods are used to detect human embryonic stem cells within a differentiated cell population with exquisite sensitivity. Differentiated cells produced from embryonic stem cells can be characterized by these methods before transplantation into a recipient, thereby providing further assurance of safety.
    Type: Application
    Filed: July 6, 2023
    Publication date: January 25, 2024
    Applicant: Astellas Institute for Regenerative Medicine
    Inventors: Irina Klimanskaya, Roger Gay
  • ASSAYS FOR POTENCY OF HUMAN RETINAL PIGMENT EPITHELIUM (RPE) CELLS AND PHOTORECEPTOR PROGENITORS
    Publication number: 20230408489
    Abstract: This disclosure provides a new phagocytosis assay to test the function of RPE cells and photoreceptor progenitors using a pH sensitive fluorescent label.
    Type: Application
    Filed: May 12, 2023
    Publication date: December 21, 2023
    Applicant: Astellas Institute for Regenerative Medicine
    Inventors: Irina Klimanskaya, Julie Kathryn Carson, Roger Gay, Yordanka Gikova Ivanova
  • Assays for potency of human retinal pigment epithelium (RPE) cells and photoreceptor progenitors
    Patent number: 11680941
    Abstract: This disclosure provides a new phagocytosis assay to test the function of RPE cells and photoreceptor progenitors using a pH sensitive fluorescent label.
    Type: Grant
    Filed: August 15, 2022
    Date of Patent: June 20, 2023
    Assignee: Astellas Institute for Regenerative Medicine
    Inventors: Irina Klimanskaya, Julie Kathryn Carson, Roger Gay, Yordanka Gikova Ivanova
  • METHODS FOR PRODUCING RETINAL PIGMENT EPITHELIUM CELLS
    Publication number: 20230072771
    Abstract: The present invention provides an improved method of producing highly pure retinal pigment epithelial (RPE) cells by differentiation of pluripotent stem cells.
    Type: Application
    Filed: October 28, 2020
    Publication date: March 9, 2023
    Inventors: Yasuhiro Takagi, Meng-jiao Shi, Mi Sook Chang, Irina Klimanskaya
  • ASSAYS FOR POTENCY OF HUMAN RETINAL PIGMENT EPITHELIUM (RPE) CELLS AND PHOTORECEPTOR PROGENITORS
    Publication number: 20230051804
    Abstract: This disclosure provides a new phagocytosis assay to test the function of RPE cells and photoreceptor progenitors using a pH sensitive fluorescent label.
    Type: Application
    Filed: August 15, 2022
    Publication date: February 16, 2023
    Applicant: Astellas Institute for Regenerative Medicine
    Inventors: Irina Klimanskaya, Julie Kathryn Carson, Roger Gay, Yordanka Gikova Ivanova
  • Modalities for the treatment of degenerative diseases of the retina
    Patent number: 9040770
    Abstract: This invention relates to methods for improved cell-based therapies for retinal degeneration and for differentiating human embryonic stem cells and human embryo-derived into retinal pigment epithelium (RPE) cells and other retinal progenitor cells.
    Type: Grant
    Filed: May 18, 2010
    Date of Patent: May 26, 2015
    Assignee: Ocata Therapeutics, Inc.
    Inventors: Irina Klimanskaya, Robert Lanza
  • METHODS FOR DETECTION OF RARE SUBPOPULATIONS OF CELLS AND HIGHLY PURIFIED COMPOSITIONS OF CELLS
    Publication number: 20130302824
    Abstract: Methods are provided for detection of a target cell type within a cell population, and compositions are provided comprising cells and an indicator that indicates the number of cells of the target cell type in the cell population. Examples are provided in which these methods are used to detect human embryonic stem cells within a differentiated cell population with exquisite sensitivity. Differentiated cells produced from embryonic stem cells can be characterized by these methods before transplantation into a recipient, thereby providing further assurance of safety.
    Type: Application
    Filed: July 25, 2011
    Publication date: November 14, 2013
    Applicant: Advanced Cell Technology, Inc.
    Inventors: Irina Klimanskaya, Roger Gay
  • MODALITIES FOR THE TREATMENT OF DEGENERATIVE DISEASES OF THE RETINA
    Publication number: 20100299765
    Abstract: This invention relates to methods for improved cell-based therapies for retinal degeneration and for differentiating human embryonic stem cells and human embryo-derived into retinal pigment epithelium (RPE) cells and other retinal progenitor cells.
    Type: Application
    Filed: May 18, 2010
    Publication date: November 25, 2010
    Inventors: Irina Klimanskaya, Robert Lanza
  • Methods for producing enriched populations of human retinal pigment epithelium cells
    Patent number: 7736896
    Abstract: This invention relates to methods for improved cell-based therapies for retinal degeneration and for differentiating human embryonic stem cells and human embryo-derived into retinal pigment epithelium (RPE) cells and other retinal progenitor cells.
    Type: Grant
    Filed: July 20, 2005
    Date of Patent: June 15, 2010
    Assignee: Advanced Cell Technology, Inc.
    Inventors: Irina Klimanskaya, Robert Lanza
  • Derivation of embryonic stem cells and embryo-derived cells
    Publication number: 20080057041
    Abstract: This present invention provides novel methods for deriving embryonic stem cells and embryo-derived cells from an embryo without requiring destruction of the embryo. The invention further provides cells and cell lines derived without embryo destruction, and the use of the cells for therapeutic and research purposes. It also relates to novel methods of establishing and storing an autologous stem cell line prior to implantation of an embryo, e.g., in conjunction with reproductive therapies such as IVF.
    Type: Application
    Filed: May 3, 2007
    Publication date: March 6, 2008
    Inventors: Young Chung, Robert Lanza, Irina Klimanskaya
  • Novel culture systems for ex vivo development
    Publication number: 20070067860
    Abstract: The present invention provides methods for the culture of animal pluripotent stem cells and their differentiated progeny cells, tissues, and organs, and nonhuman animal embryos and fetuses.
    Type: Application
    Filed: June 29, 2006
    Publication date: March 22, 2007
    Inventors: Michael West, Karen Chapman, Irina Klimanskaya
  • Modalities for the treatment of degenerative diseases of the retina
    Publication number: 20070031386
    Abstract: This invention relates to methods for improved cell-based therapies for retinal degeneration and for differentiating human embryonic stem cells and human embryo-derived into retinal pigment epithelium (RPE) cells and other retinal progenitor cells.
    Type: Application
    Filed: July 21, 2006
    Publication date: February 8, 2007
    Inventor: Irina Klimanskaya
  • Novel culture systems for ex vivo development
    Publication number: 20060112438
    Abstract: The present invention provides methods for the culture of animal pluripotent stem cells and their differentiated progeny cells, tissues, and organs, and nonhuman animal embryos and fetuses.
    Type: Application
    Filed: January 3, 2005
    Publication date: May 25, 2006
    Inventors: Michael West, Karen Chapman, Irina Klimanskaya
  • IMPROVED MODALITIES FOR THE TREATMENT OF DEGENERATIVE DISEASES OF THE RETINA
    Publication number: 20060031951
    Abstract: This invention relates to methods for improved cell-based therapies for retinal degeneration and for differentiating human embryonic stem cells and human embryo-derived into retinal pigment epithelium (RPE) cells and other retinal progenitor cells.
    Type: Application
    Filed: January 24, 2005
    Publication date: February 9, 2006
    Inventor: Irina Klimanskaya
  • Novel culture systems for EX vivo development
    Publication number: 20060031955
    Abstract: The present invention provides methods for the culture of animal pluripotent stem cells and their differentiated progeny cells, tissues, and organs, and nonhuman animal embryos and fetuses.
    Type: Application
    Filed: August 24, 2005
    Publication date: February 9, 2006
    Inventors: Michael West, Karen Chapman, Irina Klimanskaya
  • Modalities for the treatment of degenerative diseases of the retina
    Publication number: 20060018886
    Abstract: This invention relates to methods for improved cell-based therapies for retinal degeneration and for differentiating human embryonic stem cells and human embryo-derived into retinal pigment epithelium (RPE) cells and other retinal progenitor cells.
    Type: Application
    Filed: July 20, 2005
    Publication date: January 26, 2006
    Inventors: Irina Klimanskaya, Robert Lanza