Patents by Inventor Iris Archer

Iris Archer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • STING AGONISTS AND METHODS OF SELECTING STING AGONISTS
    Publication number: 20170146519
    Abstract: Disclosed are small molecules capable of activating the type I interferon (IFN) response by way of the transcription factor IFN regulatory factor 3 (IRF3) were identified. A high throughput in vitro screen yielded 4-(2-chloro-6-fluorobenzyl)-N-(furan-2-ylmethyl)-3-oxo-3,4-dihydro-2H-benzo[b][1,4]thiazine-6-carboxamide (referred to herein as G10), which was found to trigger IRF3/IFN-associated transcription in human fibroblasts. To define cellular proteins essential to elicitation of the antiviral activity by the compound a reverse genetics approach that utilized genome editing via CRISPR/Cas9 technology was employed. This allowed the identification of IRF3, the IRF3-activating adaptor molecule STING, and the IFN-associated transcription factor STAT1 as required for observed gene induction and antiviral effects.
    Type: Application
    Filed: November 21, 2016
    Publication date: May 25, 2017
    Applicant: OREGON HEALTH & SCIENCE UNIVERSITY
    Inventors: Victor DeFilippis, Tina Sali, Kara Pryke, Jinu Abraham, Andrew Liu, Iris Archer, Kayla Sheridan, Aaron Nilsen, Rebecca Broeckel, Jessica Smith, Lisi Amsler, Daniel Streblow, Andrew Placzek