Abstract: A device for unblocking and removing secretions from airways, including small airways, by applying oscillated air flow and acoustic vibrations, illustratively according to preprogrammed protocol that defines at least one of frequency, waveform, pressure amplitude, and oscillation duration. In an illustrative embodiment, the device applies a combination of air flow oscillations and acoustic waves to facilitate detachment of mucus from airway walls by matching the resonance of specific airway sections and mucus, amplifying the effect. For optimization, an algorithm illustratively matches the required frequencies, amplitudes, duty cycle, and/or relative phases to specific patient and secretion characteristics.