Patents by Inventor Iris Pecker

Iris Pecker has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8048993
    Abstract: According to the present invention there is provided an antibody that specifically binds an epitope of a heparanase protein, the heparanase protein including an amino acid sequence as set forth in SEQ ID NO:2, provided that phenylalanine replaces tyrosine at position 246. The present invention also provides an antibody elicited by an epitope of a heparanase protein, the heparanase protein including an amino acid sequence as set forth in SEQ ID NO:2, provided that phenylalanine replaces tyrosine at position 246.
    Type: Grant
    Filed: January 4, 2008
    Date of Patent: November 1, 2011
    Assignees: InSight Biopharmaceuticals Ltd., Hadasit Medical Research Services and Development Ltd.
    Inventors: Iris Pecker, Israel Vlodavsky, Yael Friedmann, Tuvia Peretz
  • Patent number: 7893240
    Abstract: The present invention provides an expression construct capable of producing high levels of erythropoietin in mammalian cells. More particularly, the expression construct includes an erythropoietin coding region fused to a unique 5?-UTR sequence and a truncated 3?-UTR. The present invention also provides methods of synthesizing large amounts of erythropoietin and in increasing serum erythropoietin level in individuals in need thereof.
    Type: Grant
    Filed: July 25, 2008
    Date of Patent: February 22, 2011
    Assignee: InSight Biopharmaceuticals Ltd.
    Inventor: Iris Pecker
  • Patent number: 7790376
    Abstract: Heparanase specific molecular probes which can be used for detection of the presence, absence or level of heparanase expression and methods of utilizing same are provided.
    Type: Grant
    Filed: May 24, 2004
    Date of Patent: September 7, 2010
    Assignees: InSight Biopharmaceuticals Ltd., Hadasit Medical Research Services and Development Ltd.
    Inventors: Iris Pecker, Israel Vlodavsky, Yael Friedmann, Tuvia Peretz
  • Patent number: 7666651
    Abstract: A polynucleotide (hpa) encoding a polypeptide having heparanase activity, vectors including same, genetically modified cells expressing heparanase, a recombinant protein having heparanase activity and antisense oligonucleotides and constructs for modulating heparanase expression.
    Type: Grant
    Filed: February 6, 2001
    Date of Patent: February 23, 2010
    Assignees: InSight Biopharmaceuticals Ltd., Hadasit Medical Research Services and Development Ltd.
    Inventors: Iris Pecker, Israel Vlodavsky, Elena Feinstein
  • Publication number: 20090275106
    Abstract: A polynucleotide (hpa) encoding a polypeptide having heparanase activity, vectors including same, genetically modified cells expressing heparanase, a recombinant protein having heparanase activity and antisense oligonucleotides and constructs for modulating heparanase expression.
    Type: Application
    Filed: October 30, 2007
    Publication date: November 5, 2009
    Applicants: Insight Strategy & Marketing Ltd., Hadasit Maedical Research Services and Development Ltd.
    Inventors: Iris Pecker, Israel Vlodavsky, Elena Feinstein
  • Publication number: 20090099341
    Abstract: A variety of heparanase specific molecular probes which can be used for research and medical applications including diagnosis and therapy. Specific applications include the use of a heparanase specific molecular probe for detection of the presence, absence or level of heparanase expression; the use of a heparanase specific molecular probe for therapy of a condition associated with expression of heparanase; the use of a heparanase specific molecular probe for quantification of heparanase in a body fluid; the use of a heparanase specific molecular probe for targeted drug delivery; and the use of a heparanase specific molecular probe as a therapeutic agent.
    Type: Application
    Filed: January 4, 2008
    Publication date: April 16, 2009
    Applicants: InSight Biopharmaceuticals Ltd., Hadasit Medical Research Services
    Inventors: Iris Pecker, Israel Vlodavsky, Yael Friedmann, Tuvia Peretz
  • Publication number: 20080312179
    Abstract: The present invention provides an expression construct capable of producing high levels of erythropoietin in mammalian cells. More particularly, the expression construct includes an erythropoietin coding region fused to a unique 5?-UTR sequence and a truncated 3?-UTR. The present invention also provides methods of synthesizing large amounts of erythropoietin and in increasing serum erythropoietin level in individuals in need thereof.
    Type: Application
    Filed: July 25, 2008
    Publication date: December 18, 2008
    Applicant: InSight Biopharmaceuticals Ltd.
    Inventor: Iris Pecker
  • Patent number: 7423139
    Abstract: The present invention provides an expression construct capable of producing high levels of erythropoietin in mammalian cells. More particularly, the expression construct includes an erythropoietin coding region fused to a unique 5?-UTR sequence and a truncated 3?-UTR. The present invention also provides methods of synthesizing large amounts of erythropoietin and in increasing serum erythropoietin level in individuals in need thereof.
    Type: Grant
    Filed: January 20, 2004
    Date of Patent: September 9, 2008
    Assignee: InSight Biopharmaceuticals Ltd.
    Inventor: Iris Pecker
  • Patent number: 7339038
    Abstract: A variety of heparanase specific molecular probes which can be used for research and medical applications including diagnosis and therapy. Specific applications include the use of a heparanase specific molecular probe for detection of the presence, absence or level of heparanase expression; the use of a heparanase specific molecular probe for therapy of a condition associated with expression of heparanase; the use of a heparanase specific molecular probe for quantification of heparanase in a body fluid; the use of a heparanase specific molecular probe for targeted drug delivery; and the use of a heparanase specific molecular probe as a therapeutic agent.
    Type: Grant
    Filed: October 2, 2003
    Date of Patent: March 4, 2008
    Assignees: InSight Biopharmaceuticals Ltd., Hadasit Medical Research Services and Development Ltd.
    Inventors: Iris Pecker, Israel Vlodavsky, Yael Friedmann, Tuvia Peretz
  • Publication number: 20060269552
    Abstract: Specific anti-heparanase antibodies which bind specifically to heparanase having sequence homology to human heparanase, which can be used to treat and diagnose conditions associated with heparanase catalytic activity, for purification of heparanase, and for drug development in heparanase associated conditions are disclosed.
    Type: Application
    Filed: June 3, 2004
    Publication date: November 30, 2006
    Inventors: Oron Yacoby-Zeevi, Tuvia Peretz, Daphna Miron, Yinon Shlomi, Iris Pecker, Maty Ayal-Hershkovitz
  • Publication number: 20060223108
    Abstract: Methods and kits for distinguishing between heparanase expressing and heparanase non-expressing hematopoietic cells, particularly useful in distinguishing between different types of differentiated and/or undifferentiated lymphomas and leukemias. The methods and kits are designed to detect heparanase expression, or absence thereof, at the gene, protein and/or protein activity levels.
    Type: Application
    Filed: June 9, 2006
    Publication date: October 5, 2006
    Inventors: Iris Pecker, Israel Vlodavsky, Ben Katz, Amiram Eldor, Menachem Bitan, Aaron Polliack, Arnon Nagler, Zofia Eldor
  • Patent number: 7101706
    Abstract: The present invention relates to novel polynucleotides encoding polypeptides homologous to heparanase, nucleic acid constructs including these novel polynucleotides, genetically modified cells expressing the same, recombinant proteins encoded thereby and which may have heparanase or other glycosyl hydrolase activity, antibodies recognizing the recombinant proteins, oligonucleotides, analogs thereof and ribozymes derived from these polynucleotides.
    Type: Grant
    Filed: June 19, 2000
    Date of Patent: September 5, 2006
    Assignee: InSight Biopharmaceuticals Ltd.
    Inventors: Iris Pecker, Israel Michal, Hanan Itzhaki
  • Patent number: 7049407
    Abstract: A variety of heparanase specific antibodies which can be used for research and medical applications including diagnosis and therapy. Specific applications include the use of a heparanase specific antibodies for detection of the presence, absence or level of heparanase expression; the use of a heparanase specific antibodies for therapy of a condition associated with expression of heparanase; the use of a heparanase specific antibodies for quantification of heparanase in a body fluid; the use of a heparanase specific antibodies for targeted drug delivery; and the use of a heparanase specific antibodies as a therapeutic agent.
    Type: Grant
    Filed: January 16, 2001
    Date of Patent: May 23, 2006
    Assignees: InSight Biopharmaceuticals Ltd., Hadasit Medical Research Services and Development Ltd.
    Inventors: Iris Pecker, Israel Vlodavsky, Yael Friedman, Tuvia Perets
  • Patent number: 6986996
    Abstract: A variety of heparanase specific molecular probes which can be used for research and medical applications including diagnosis and therapy. Specific applications include the use of a heparanase specific molecular probe for detection of the presence, absence or level of heparanase expression; the use of a heparanase specific molecular probe for therapy of a condition associated with expression of heparanase; the use of a heparanase specific molecular probe for quantification of heparanase in a body fluid; the use of a heparanase specific molecular probe for targeted drug delivery; and the use of a heparanase specific molecular probe as a therapeutic agent.
    Type: Grant
    Filed: February 26, 2004
    Date of Patent: January 17, 2006
    Assignees: Insight Biopharmaceuticals Ltd., Hadasit Medical Research Services and Development Ltd.
    Inventors: Iris Pecker, Israel Vlodavsky, Yael Friedmann, Tuvia Peretz
  • Publication number: 20050260187
    Abstract: Methods and compositions for inducing and/or accelerating wound healing and/or angiogenesis via the catalytic activity of heparanase are disclosed.
    Type: Application
    Filed: April 15, 2005
    Publication date: November 24, 2005
    Inventors: Neta Ilan, Israel Vlodavsky, Oron Yacoby-Zeevi, Iris Pecker, Elena Feinstein
  • Patent number: 6960471
    Abstract: A polynucleotide (hpa) encoding a polypeptide having heparanase activity, vectors including same, genetically modified cells expressing heparanase, a recombinant protein having heparanase activity and antisense oligonucleotides and constructs for modulating heparanase expression.
    Type: Grant
    Filed: March 10, 2003
    Date of Patent: November 1, 2005
    Assignees: InSight Biopharmaceuticals Ltd., Hadasit Medical Research Services and Development Ltd.
    Inventors: Iris Pecker, Israel Vlodavsky, Elena Feinstein
  • Patent number: 6946131
    Abstract: A method of treating a condition associated with heparanase expression by administering a heparanase activity neutralizing monoclonal anti-heparanase antibody, the monoclonal anti-heparanase antibody being for neutralizing heparanase catalytic activity.
    Type: Grant
    Filed: February 19, 2003
    Date of Patent: September 20, 2005
    Assignees: InSight Biopharmacenticals Ltd., Hadasit Medical Research Services and Development Ltd.
    Inventors: Tuvia Peretz, Daphna Miron, Yinon Shlomi, Iris Pecker, Maty Ayal-Hershkovitz, Israel Vlodavsky, Yael Friedmann
  • Publication number: 20050158822
    Abstract: The present invention provides an expression construct capable of producing high levels of erythropoietin in mammalian cells. More particularly, the expression construct includes an erythropoietin coding region fused to a unique 5?-UTR sequence and a truncated 3?-UTR. The present invention also provides methods of synthesizing large amounts of erythropoietin and in increasing serum erythropoietin level in individuals in need thereof.
    Type: Application
    Filed: January 20, 2004
    Publication date: July 21, 2005
    Inventor: Iris Pecker
  • Publication number: 20050070000
    Abstract: Novel polynucleotides encoding polypeptides distantly homologous to heparanase, nucleic acid constructs including the polynucleotides, genetically modified cells expressing same, recombinant proteins encoded thereby and which may have heparanase or other glycosyl hydrolase activity, antibodies recognizing the recombinant proteins, oligonucleotide's and oligonucleotide analogs derived from the polynucleotides and ribozymes including same.
    Type: Application
    Filed: September 13, 2004
    Publication date: March 31, 2005
    Inventors: Iris Pecker, Israel Michal, Hanan Itzhaki
  • Publication number: 20040229834
    Abstract: Heparanase specific molecular probes which can be used for detection of the presence, absence or level of heparanase expression and methods of utilizing same are provided.
    Type: Application
    Filed: May 24, 2004
    Publication date: November 18, 2004
    Inventors: Iris Pecker, Israel Vlodavsky, Yael Friedmann, Tuvia Peretz