Patents by Inventor Iris Walker

Iris Walker has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Solubilization and purification of a target protein fused to a mutant maltose-binding protein
    Patent number: 8623615
    Abstract: Methods and compositions are provided that relate to a composition that includes a modified maltose-binding protein (MBP) which when fused to a protein results in an increase in binding affinity for maltodextrin compared with the wild type MBP fused to the protein, the modified MBP maintaining enhanced solubility. The modification includes a mutation selected from the group consisting of: F68L, I318V, Q326R, V344M, and T372TTTITITTTLGIEGR387 or consists of two or more mutations selected from the group consisting of: F68L, S146T, A313V, I318V, I318A, Q326R, V344M and T372TTTITITTTLGIEGR387 mutants.
    Type: Grant
    Filed: April 1, 2009
    Date of Patent: January 7, 2014
    Assignee: New England Biolabs, Inc.
    Inventors: Paul Riggs, Iris Walker, Paul A. Colussi, Mehul Ganatra, Christopher H. Taron
  • Solubilization and Purification of a Target Protein Fused to a Mutant Maltose-Binding Protein
    Publication number: 20120028305
    Abstract: Methods and compositions are provided that relate to a composition that includes a modified maltose-binding protein (MBP) which when fused to a protein results in an increase in binding affinity for maltodextrin compared with the wild type MBP fused to the protein, the modified MBP maintaining enhanced solubility, The modification includes a mutation selected from the group consisting of: F68L, I318V, Q326R, V344M, and T372TTTITITTTLGIEGR387 or consist of two or more mutations selected from the group consisting of: F68L, S146T, A313V, I318V, I318A, Q326R, V344M and T372TTTITITTTLGIEGR387 mutants.
    Type: Application
    Filed: April 1, 2009
    Publication date: February 2, 2012
    Applicant: NEW ENGLAND BIOLABS, INC.
    Inventors: Paul Riggs, Iris Walker, Paul A. Colussi, Mehul Ganatra, Christopher H. Taron
  • Solubilization and purification of a target protein fused to a mutant maltose-binding protein
    Patent number: 7883867
    Abstract: Methods and compositions are provided for increasing at least one of: (i) binding affinity of a target protein for a maltodextrin substrate and/or (ii) solubility of a target protein. The methods and compositions relate to a modified maltose-binding protein.
    Type: Grant
    Filed: August 16, 2010
    Date of Patent: February 8, 2011
    Assignee: New England Biolabs, Inc.
    Inventors: Paul Riggs, Pei-Chung Hsieh, Iris Walker, Paul A. Colussi, Mehul Ganatra, Christopher H. Taron
  • SOLUBILIZATION AND PURIFICATION OF A TARGET PROTEIN FUSED TO A MUTANT MALTOSE-BINDING PROTEIN
    Publication number: 20110020911
    Abstract: Methods and compositions are provided for increasing at least one of: (i) binding affinity of a target protein for a maltodextrin substrate and/or (ii) solubility of a target protein. The methods and compositions relate to a modified maltose-binding protein.
    Type: Application
    Filed: August 16, 2010
    Publication date: January 27, 2011
    Applicant: New England Biolabs, Inc.
    Inventors: Paul Riggs, Pei-Chung Hsieh, Iris Walker, Paul A. Colussi, Mehul Ganatra, Christopher H. Taron
  • Solubilization and purification of a target protein fused to a mutant maltose-binding protein
    Patent number: 7825218
    Abstract: Methods and compositions are provided for increasing at least one of: (i) binding affinity of a target protein for a maltodextrin substrate and/or (ii) solubility of a target protein. The methods and compositions relate to a modified maltose-binding protein.
    Type: Grant
    Filed: April 14, 2007
    Date of Patent: November 2, 2010
    Assignee: New England Biolabs, Inc.
    Inventors: Paul Riggs, Pei-Chung Hsieh, Iris Walker, Paul A. Colussi, Mehul Ganatra, Christopher H. Taron
  • Solubilization and Purification of a Target Protein fused to a Mutant Maltose-Binding Protein
    Publication number: 20090305342
    Abstract: Methods and compositions are provided for increasing at least one of: (i) binding affinity of a target protein for a maltodextrin substrate and/or (ii) solubility of a target protein. The methods and compositions relate to a modified maltose-binding protein.
    Type: Application
    Filed: April 14, 2007
    Publication date: December 10, 2009
    Applicant: NEW ENGLAND BIOLABS, INC.
    Inventors: Paul Riggs, Pei-Chung Hsieh, Iris Walker, Paul A. Colussi, Mehul Ganatra, Christopher H. Taron