Abstract: A system and method is provided that includes acquiring chemical exchange saturation transfer (CEST) data with the MRI system and generating an acquired Z-spectrum (Z) from the CEST data. The system and method also includes computing an estimated direct water saturation (Z?) based using at least one of relaxation measurements derived from the CEST data or imaging parameters used to acquire the CEST data with the MRI system, computing a direct saturation corrected Z-spectrum (?Z) using the acquired Z-spectrum (Z) and the estimated direct water saturation (Z?), and generating a CEST image of the subject using the direct saturation corrected Z-spectrum (?Z).

Abstract: The present disclosure relates to systems and methods for determining quantitative chemical exchange or exchangeable proton information from a region-of-interest in a subject. The methods and systems use adaptive fitting to quantify magnetic resonance (MR) data, such as chemical exchange saturation transfer magnetic resonance imaging (CEST MRI) images, using initial values based on, for example, Lorentzian fitting. Images are iteratively less downsampled until quantitative maps of desired resolution are obtained. Such an approach allows for reliable fitting at a faster fitting speed, and is less susceptible to suboptimal signal to noise (SNR) than conventional methods.

Abstract: A system and method is provided that includes acquiring chemical exchange saturation transfer (CEST) data with the MRI system and generating an acquired Z-spectrum (Z) from the CEST data. The system and method also includes computing an estimated direct water saturation (Z?) based using at least one of relaxation measurements derived from the CEST data or imaging parameters used to acquire the CEST data with the MRI system, computing a direct saturation corrected Z-spectrum (?Z) using the acquired Z-spectrum (Z) and the estimated direct water saturation (Z?), and generating a CEST image of the subject using the direct saturation corrected Z-spectrum (?Z).

Abstract: The present disclosure relates to systems and methods for determining quantitative chemical exchange or exchangeable proton information from a region-of-interest in a subject. The methods and systems use adaptive fitting to quantify magnetic resonance (MR) data, such as chemical exchange saturation transfer magnetic resonance imaging (CEST MRI) images, using initial values based on, for example, Lorentzian fitting. Images are iteratively less downsampled until quantitative maps of desired resolution are obtained. Such an approach allows for reliable fitting at a faster fitting speed, and is less susceptible to suboptimal signal to noise (SNR) than conventional methods.