Patents by Inventor Irun R. Cohen

Irun R. Cohen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11047855
    Abstract: Methods and kits for diagnosing or monitoring systemic lupus erythematosus (SLE) in a subject are provided. Particularly, provided is a specific antibody reactivity profile useful in diagnosing or monitoring SLE in a subject.
    Type: Grant
    Filed: February 29, 2016
    Date of Patent: June 29, 2021
    Assignees: IMMUNARRAY LTD., YEDA RESEARCH AND DEVELOPMENT CO. LTD.
    Inventors: Rachel Sorek, Keren Jakobi, Pennina Safer, Anat Reiner-Benaim, Irun R. Cohen
  • Patent number: 11002735
    Abstract: Method, system and an article of manufacture for clustering and thereby identifying predefined antigens reactive with undetermined immunoglobulins of sera derived from patient subjects in need of diagnosis of disease or monitoring of treatment.
    Type: Grant
    Filed: January 21, 2020
    Date of Patent: May 11, 2021
    Assignee: YEDA RESEARCH AND DEVELOPMENT CO. LTD.
    Inventors: Irun R. Cohen, Eytan Domany, Francisco Javier Quintana, Guy Hed, Gad Getz
  • Publication number: 20210041455
    Abstract: The present invention relates to uses of a peptide comprising an amino acid sequence selected from the group consisting of SEQ ID NO: 1, SEQ ID NO: 2, analogues and derivatives thereof, for the treatment of neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS). The present invention further provides a method for assessing responsiveness to treatment with the peptide of the invention. In addition, the present invention relates to prognosis of ALS progression, using Akt and phosphorylated Akt as biomarkers.
    Type: Application
    Filed: October 27, 2020
    Publication date: February 11, 2021
    Applicants: Yeda Research and Development Co. Ltd., Universitätsklinikum Hamburg-Eppendorf
    Inventors: Eran OVADIA, Irun R. COHEN, Johannes HERKEL, Raanan MARGALIT, Meirav PEVSNER-FISCHER
  • Publication number: 20200264172
    Abstract: Methods and kits for diagnosing systemic lupus erythematosus (SLE) in a subject are provided. Particularly, the present invention relates to specific oligonucleotide antibody reactivities useful in diagnosing SLE in a subject.
    Type: Application
    Filed: January 24, 2020
    Publication date: August 20, 2020
    Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.
    Inventors: Irun R. COHEN, Eytan DOMANY, Noam SHENTAL, Ittai FATTAL
  • Publication number: 20200225222
    Abstract: Assays, kits and methods useful in the field of systemic lupus erythematosus (SLE) diagnosis and management for determining and providing SLE treatment adjustment include methods for detecting SLE resolution and for adjusting treatment in a subject hitherto diagnosed as having SLE.
    Type: Application
    Filed: September 17, 2018
    Publication date: July 16, 2020
    Inventors: Rachel SOREK, Keren JAKOBI-BROOK, Pennina SAFER, Irun R. COHEN
  • Publication number: 20200225223
    Abstract: Method, system and an article of manufacture for clustering and thereby identifying predefined antigens reactive with undetermined immunoglobulins of sera derived from patient subjects in need of diagnosis of disease or monitoring of treatment.
    Type: Application
    Filed: January 21, 2020
    Publication date: July 16, 2020
    Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.
    Inventors: Irun R. COHEN, Eytan DOMANY, Francisco Javier QUINTANA, Guy HED, Gad GETZ
  • Publication number: 20200114022
    Abstract: The present disclosure provides methods and compositions for treatment of an HLA-B27-associated autoimmune inflammatory disorder by administration of nucleic acid encoding HSP90 or an active fragment thereof.
    Type: Application
    Filed: March 28, 2018
    Publication date: April 16, 2020
    Inventors: Irun R. Cohen, Denis Ravel, Raanan Margalit, Binah Baum
  • Patent number: 10545144
    Abstract: Methods and kits for diagnosing systemic lupus erythematosus (SLE) in a subject are provided. Particularly, the present invention relates to specific oligonucleotide antibody reactivities useful in diagnosing SLE in a subject.
    Type: Grant
    Filed: December 31, 2014
    Date of Patent: January 28, 2020
    Assignee: YEDA RESEARCH AND DEVELOPMENT CO., LTD.
    Inventors: Irun R. Cohen, Eytan Domany, Noam Shental, Ittai Fattal
  • Publication number: 20190204340
    Abstract: The present invention relates to uses of a peptide comprising an amino acid sequence selected from the group consisting of SEQ ID NO: 1, SEQ ID NO: 2, analogues and derivatives thereof, for the treatment of neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS). The present invention further provides a method for assessing responsiveness to treatment with the peptide of the invention. In addition, the present invention relates to prognosis of ALS progression, using Akt and phosphorylated Akt as biomarkers.
    Type: Application
    Filed: March 14, 2019
    Publication date: July 4, 2019
    Applicants: Yeda Research and Development Co. Ltd., Universitätsklinikum Hamburg-Eppendorf
    Inventors: Eran OVADIA, Irun R. COHEN, Johannes HERKEL, Raanan MARGALIT, Meirav PEVSNER-FISCHER
  • Patent number: 10288622
    Abstract: The present invention relates to uses of a peptide comprising an amino acid sequence selected from the group consisting of SEQ ID NO: 1, SEQ ID NO: 2, analogs and derivatives thereof, for the treatment of neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS). The present invention further provides a method for assessing responsiveness to treatment with the peptide of the invention. In addition, the present invention relates to prognosis of ALS progression, using Akt and phosphorylated Akt as biomarkers.
    Type: Grant
    Filed: October 15, 2015
    Date of Patent: May 14, 2019
    Assignees: Yeda Research and Development Co. Ltd., Universitätsklinikum Hamburg-Eppendorf
    Inventors: Eran Ovadia, Irun R. Cohen, Johannes Herkel, Raanan Margalit, Meirav Pevsner-Fischer
  • Patent number: 10226517
    Abstract: A method of treating a T cell-mediated inflammatory autoimmune disease by administering to an individual in need thereof an immunogenic composition comprising a recombinant construct of a nucleic acid sequence encoding heat shock protein 90 (HSP 90), or an active fragment thereof, wherein the nucleic acid sequence is operatively linked to one or more transcription control sequences. The disease is other than insulin dependent diabetes mellitus (IDDM) or rheumatoid arthritis. The administering of the immunogenic composition results in a shift of the immune response to a Th2 response, thereby treating the disease.
    Type: Grant
    Filed: April 19, 2018
    Date of Patent: March 12, 2019
    Assignee: Alma Bio Therapeutics
    Inventors: Irun R. Cohen, Francisco J. Quintana, Pnina Carmi, Felix Mor
  • Publication number: 20190004045
    Abstract: Method, system and an article of manufacture for clustering and thereby identifying predefined antigens reactive with undetermined immunoglobulins of sera derived from patient subjects in need of diagnosis of disease or monitoring of treatment.
    Type: Application
    Filed: September 6, 2018
    Publication date: January 3, 2019
    Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.
    Inventors: Irun R. COHEN, Eytan DOMANY, Francisco Javier QUINTANA, Guy HED, Gad GETZ
  • Patent number: 10082503
    Abstract: Method, system and an article of manufacture for clustering and thereby identifying predefined antigens reactive with undetermined immunoglobulins of sera derived from patient subjects in need of diagnosis of disease or monitoring of treatment.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: September 25, 2018
    Assignee: YEDA RESEARCH AND DEVELOPMENT CO. LTD.
    Inventors: Irun R. Cohen, Eytan Domany, Francisco Javier Quintana, Guy Hed, Gad Getz
  • Publication number: 20180236052
    Abstract: A method of treating a T cell-mediated inflammatory autoimmune disease by administering to an individual in need thereof an immunogenic composition comprising a recombinant construct of a nucleic acid sequence encoding heat shock protein 90 (HSP 90), or an active fragment thereof, wherein the nucleic acid sequence is operatively linked to one or more transcription control sequences. The disease is other than insulin dependent diabetes mellitus (IDDM) or rheumatoid arthritis. The administering of the immunogenic composition results in a shift of the immune response to a Th2 response, thereby treating the disease.
    Type: Application
    Filed: April 19, 2018
    Publication date: August 23, 2018
    Inventors: Irun R. Cohen, Francisco J. Quintana, Pnina Carmi, Felix Mor
  • Patent number: 9974843
    Abstract: A method of treating a T cell-mediated inflammatory autoimmune disease by administering to an individual in need thereof an immunogenic composition comprising a recombinant construct of a nucleic acid sequence encoding heat shock protein 90 (HSP 90), or an active fragment thereof, wherein the nucleic acid sequence is operatively linked to one or more transcription control sequences. The disease is other than insulin dependent diabetes mellitus (IDDM) or rheumatoid arthritis. The administering of the immunogenic composition results in a shift of the immune response to a Th2 response, thereby treating the disease.
    Type: Grant
    Filed: February 1, 2016
    Date of Patent: May 22, 2018
    Assignee: Alma Bio Therapeutics
    Inventors: Irun R. Cohen, Francisco J. Quintana, Pnina Carmi, Felix Mor
  • Publication number: 20170174764
    Abstract: The present invention provides isolated peptides derived from TCR CDR3 segments, antibodies which recognize them, pharmaceutical compositions comprising them and methods of their use for modulating self-immunity.
    Type: Application
    Filed: March 26, 2015
    Publication date: June 22, 2017
    Inventors: Irun R. COHEN, Nir FRIEDMAN, Asaf MADI, Eric SHIFRUT, Shlomit REICH-ZELIGER, Asaf PORAN
  • Publication number: 20170016895
    Abstract: Methods and kits for diagnosing systemic lupus erythematosus (SLE) in a subject are provided. Particularly, the present invention relates to specific oligonucleotide antibody reactivities useful in diagnosing SLE in a subject.
    Type: Application
    Filed: December 31, 2014
    Publication date: January 19, 2017
    Inventors: Irun R. Cohen, Eytan Domany, Noam Shental, Ittai Fattal
  • Publication number: 20170000865
    Abstract: A method of treating a T cell-mediated inflammatory autoimmune disease by administering to an individual in need thereof an immunogenic composition comprising a recombinant construct of a nucleic acid sequence encoding heat shock protein 90 (HSP 90), or an active fragment thereof, wherein the nucleic acid sequence is operatively linked to one or more transcription control sequences. The disease is other than insulin dependent diabetes mellitus (IDDM) or rheumatoid arthritis. The administering of the immunogenic composition results in a shift of the immune response to a Th2 response, thereby treating the disease.
    Type: Application
    Filed: February 1, 2016
    Publication date: January 5, 2017
    Inventors: Irun R. Cohen, Francisco J. Quintana, Pnina Carmi, Felix Mor
  • Publication number: 20160320384
    Abstract: A method of assaying or monitoring the determining immunological competence of a subject, particularly for determining immunological competence in a subject, including but not limited to a transplant recipient, is provided. The method comprises measuring the levels of antibodies in a sample obtained from a subject to poly-guanine oligonucleotides.
    Type: Application
    Filed: December 31, 2014
    Publication date: November 3, 2016
    Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.
    Inventors: Irun R. Cohen, Eytan Domany, Noam Shental, Ittai Fattal
  • Patent number: 9474744
    Abstract: Compositions and methods comprising ampicillin or salts and derivative thereof for the treatment of delaying the onset of type I diabetes are provided.
    Type: Grant
    Filed: September 20, 2012
    Date of Patent: October 25, 2016
    Assignee: STEM CELL MEDICINE LTD.
    Inventors: Irun R. Cohen, Felix Mor