Abstract: This disclosure provides compositions and related methods providing targeted cell-specific inhibition of Notch receptor signaling. The disclosure provides a bi-specific molecule with separate domains that target the intended cell-type and the Notch receptor on that cell-type. The disclosure also provides for nucleic acids, vectors, and cells allowing for the expression of the bi-specific fusion molecules. The disclosure also provides related methods of making and using the bi-specific fusion molecule to inhibit Notch signaling in target cells of interest, including for the treatment of diseases characterized by a dysregulation of Notch signaling.

Abstract: This disclosure provides compositions and related methods providing targeted cell-specific inhibition of Notch receptor signaling. The disclosure provides a bi-specific molecule with separate domains that target the intended cell-type and the Notch receptor on that cell-type. The disclosure also provides for nucleic acids, vectors, and cells allowing for the expression of the bi-specific fusion molecules. The disclosure also provides related methods of making and using the bi-specific fusion molecule to inhibit Notch signaling in target cells of interest, including for the treatment of diseases characterized by a dysregulation of Notch signaling.

Abstract: Certain embodiments of the present invention provide Credit Grantors with an alternative to warehousing or the selling of aged accounts receivables. Certain embodiments of the present invention provide Creditors immediate cash for their accounts receivables placed on lease, shifts the cost, liabilities and collection efforts to a third party and still allows the Creditor to maintain ownership and oversight over the collection process. Certain embodiments of the present invention provide a non-recourse lease that may eliminate financial responsibility on the part of the Creditor. Certain embodiments of the present invention provide a residual payment back to the creditor that may allow the Creditor to share in the collection proceeds. Certain embodiments of the present invention provide monthly reporting to keep the Creditor informed as to collection results and to allow collection data to be used in analysis of the Creditor's credit policies, as well as other data mining jobs.