Patents by Inventor Irwin Fridovich
Irwin Fridovich has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20080113956Abstract: The present invention relates, in general, to a method of modulating physiological and pathological processes and, in particular, to a method of modulating cellular levels of oxidants and thereby processes in which such oxidants are a participant. The invention also relates to compounds and compositions suitable for use in such methods.Type: ApplicationFiled: January 17, 2008Publication date: May 15, 2008Inventors: Irwin Fridovich, Ines Batinic-Haberle, James Crapo, Brian Day
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Publication number: 20080021007Abstract: To improve bioavailability of the catalytic metalloporphyrin-based SOD mimics Mn(III) 5,10,15,20-tetrakis[N-ethylpyridinium-2-yl]porphyrin (MnTE-2-PyP5+) and Mn(III) 5,10,15,20-tetrakis[N,N?-diethylimidazolium-2-yl]porphyrin (MnTDE-2-ImP5+), three new Mn(III) porphyrins, bearing oxygen atoms within side chains, were synthesized and characterized: Mn(III) 5,10,15,20-tetrakis[N-(2-methoxyethyl)pyridinium-2-yl]porphyrin (MnTMOE-2-PyP5+), Mn(III) 5,10,15,20-tetrakis[N-methyl-N?-(2-methoxyethyl)imidazolium-2-yl]porphyrin (MnTM,MOE-2-ImP5+) and Mn(III) 5,10,15,20-tetrakis[N,N?-di(2-methoxyethyl)imidazolium-2-yl]porphyrin (MnTDMOE-2-ImP5+). The catalytic rate constants for O2 dismutation (and the related metal-centered redox potentials vs NHE) for the new compounds are: log kcat=8.04 (E½=+251 mV) for MnTMOE-2-PyP5+, log kcat=7.98 (E½=+356 mV) for MnTM,MOE-2-ImP5+ and log kcat=7.59 (E½=+365 mV) for MnTDMOE-2-ImP5+. At 30 ?M levels none of the new compounds were toxic, and allowed SOD-deficient E.Type: ApplicationFiled: February 1, 2005Publication date: January 24, 2008Inventors: Ines Batinic-Haberle, Irwin Fridovich, Ivan Spasojevic
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Publication number: 20070197496Abstract: The present invention relates, in general, to a method of modulating physiological and pathological processes and, in particular, to a method of modulating cellular levels of oxidants and thereby processes in which such oxidants are a participant. The invention also relates to compounds and compositions suitable for use in such methods.Type: ApplicationFiled: June 16, 2006Publication date: August 23, 2007Inventors: James Crapo, Brian Day, Michael Trova, Polvina Gauuan, Douglas Kitchen, Irwin Fridovich, Ines Batinic-Haberle
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Publication number: 20070179124Abstract: The present invention relates, in general, to a method of modulating physiological and pathological processes and, in particular, to a method of modulating cellular levels of oxidants and thereby processes in which such oxidants are a participant. The invention also relates to compounds and compositions suitable for use in such methods.Type: ApplicationFiled: September 15, 2006Publication date: August 2, 2007Inventors: Irwin Fridovich, Ines Batinic-Haberle, James Crapo, Brian Day
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Patent number: 7189707Abstract: The present invention relates, in general, to a method of modulating physiological and pathological processes and, in particular, to a method of modulating cellular levels of oxidants and thereby processes in which such oxidants are a participant. The invention also relates to compounds and compositions suitable for use in such methods.Type: GrantFiled: January 23, 2003Date of Patent: March 13, 2007Assignees: National Jewish Medical Research Center, Duke University, Aeolus Sciences, Inc.Inventors: James D. Crapo, Brian J. Day, Michael P. Trova, Polivina Jolicia F. Gauuan, Douglas B. Kitchen, Irwin Fridovich, Ines Batinic-Haberle
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Publication number: 20060074062Abstract: The present invention relates, in general, to a method of modulating physiological and pathological processes and, in particular, to a method of modulating cellular levels of oxidants and thereby processes in which such oxidants are a participant. The invention also relates to compounds and compositions suitable for use in such methods.Type: ApplicationFiled: May 12, 2005Publication date: April 6, 2006Applicants: DUKE UNIVERSITY, NATIONAL JEWISH MEDICAL AND RESEARCH CENTERInventors: Irwin Fridovich, Ines Batinic-Haberle, James Crapo, Brian Day
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Patent number: 6916799Abstract: The present invention relates, in general, to a method of modulating physiological and pathological processes and, in particular, to a method of modulating cellular levels of oxidants and thereby processes in which such oxidants are a participant. The invention also relates to compounds and compositions suitable for use in such methods.Type: GrantFiled: June 14, 2001Date of Patent: July 12, 2005Assignees: Duke University, National Jewish Medical and Research CenterInventors: Irwin Fridovich, Ines Batinic-Haberle, James D. Crapo, Brian J. Day
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Publication number: 20040058902Abstract: A series of ortho isomers of meso tetrakis N-alkylpyridylporphyrins (alkyl being methyl, ethyl, n-propyl, n-butyl, n-hexyl, and n-octyl) and their Mn(III) complexes were synthesized and characterized by elemental analysis, uv/vis spectroscopy, electrospray ionization mass spectrometry and electrochemistry. An increase in the number of carbon atoms in the alkyl chains from 1 to 8 is accompanied by an increase in: (a) lipophilicity measured by the chromatographic retention factor, Rf; (b) metal-entered redox potential, E1/2 from +220 to +367 mV vs NHE, and (c) proton dissociation constant, pKa2 from 10.9 to 13.2. A linear correlation was found between E1/2 and Rf of the Mn(III) porphyrins and between the pKa2 and Rf of the metal-free compounds. As the porphyrins become increasingly more lipophilic, the decrease in hydration disfavors the separation of charges, while enhancing the electron-withdrawing effect of the positively charged pyridyl nitrogen atoms.Type: ApplicationFiled: June 9, 2003Publication date: March 25, 2004Applicant: DUKE UNIVERSITYInventors: Ines Batinic-Haberle, Ivan Spasojevic, Irwin Fridovich
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Publication number: 20040039211Abstract: The present invention relates, in general, to a method of modulating physiological and pathological processes and, in particular, to a method of modulating cellular levels of oxidants and thereby processes in which such oxidants are a participant. The invention also relates to compounds and compositions suitable for use in such methods.Type: ApplicationFiled: April 28, 2003Publication date: February 26, 2004Applicant: DUKE UNIVERSITY AND NATIONAL JEWISH MEDICAL AND RESEARCH CENTERInventors: Irwin Fridovich, Ines Batinic-Haberle, Ivan Spasojevic, James D. Crapo, Brian J. Day
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Publication number: 20040023941Abstract: The present invention relates, in general, to a method of modulating physiological and pathological processes and, in particular, to a method of modulating cellular levels of oxidants and thereby processes in which such oxidants are a participant. The invention also relates to compounds and compositions suitable for use in such methods.Type: ApplicationFiled: January 23, 2003Publication date: February 5, 2004Applicants: NATIONAL JEWISH MEDICAL AND RESEARCH CENTER, AEOLUS PHARMACEUTICALS, INC., DUKE UNIVERSITYInventors: James D. Crapo, Brian J. Day, Michael P. Trova, Polivina Jolicia F. Gauuan, Douglas B. Kitchen, Irwin Fridovich, Ines Batinic-Haberle
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Publication number: 20040019031Abstract: The present invention relates, in general, to a method of modulating physiological and pathological processes and, in particular, to a method of modulating intra- and extracellular levels of oxidants and thereby processes in which such oxidants are a participant. The invention also relates to compounds and compositions suitable for use in such methods.Type: ApplicationFiled: June 9, 2003Publication date: January 29, 2004Applicants: DUKE UNIVERSITY, UNIVERSITY OF ALABAMA AT BIRMINGHAM RESEARCH FOUNDATION, AEOLUS PHARMACEUTICALS, INC.Inventors: James D. Crapo, Irwin Fridovich, Tim Oury, Brian J. Day, Rodney J. Folz, Bruce A. Freeman, Michael P. Trova, Ines Batinic-Haberle
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Patent number: 6583132Abstract: The present invention relates, in general, to a method of modulating physiological and pathological processes and, in particular, to a method of modulating intra- and extracellular levels of oxidants and thereby processes in which such oxidants are a participant. The invention also relates to compounds and compositions suitable for use in such methods.Type: GrantFiled: November 30, 1998Date of Patent: June 24, 2003Assignees: Duke University, University of Alabama at Birmingham Research Foundation, Aeolus Pharmaceuticals, Inc.Inventors: James D. Crapo, Irwin Fridovich, Tim Oury, Brian J. Day, Rodney J. Folz, Bruce A. Freeman, Michael P. Trova, Ines Batinic-Haberle
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Publication number: 20030069281Abstract: The present invention relates, in general, to a method of modulating physiological and pathological processes and, in particular, to a method of modulating cellular levels of oxidants and thereby processes in which such oxidants are a participant. The invention also relates to compounds and compositions suitable for use in such methods.Type: ApplicationFiled: June 14, 2001Publication date: April 10, 2003Inventors: Irwin Fridovich, Ines Batinic-Haberle, Ivan Spasojevic, James D. Crapo, Brian J. Day
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Patent number: 6544975Abstract: The present invention relates, in general, to a method of modulating physiological and pathological processes and, in particular, to a method of modulating cellular levels of oxidants and thereby processes in which such oxidants are a participant. The invention also relates to compounds and compositions suitable for use in such methods.Type: GrantFiled: January 25, 2000Date of Patent: April 8, 2003Assignees: National Jewish Medical and Research Center, Aeolus Pharmaceuticals INC, Duke UniversityInventors: James D. Crapo, Brian J. Day, Michael P. Trova, Polivina Jolicia F. Gauuan, Douglas B. Kitchen, Irwin Fridovich, Ines Batinic-Haberle
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Publication number: 20020042407Abstract: The present invention relates, in general, to a method of modulating physiological and pathological processes and, in particular, to a method of modulating cellular levels of oxidants and thereby processes in which such oxidants are a participant. The invention also relates to compounds and compositions suitable for use in such methods.Type: ApplicationFiled: June 14, 2001Publication date: April 11, 2002Applicant: DUKE UNIVERSITYInventors: Irwin Fridovich, Ines Batinic-Haberle
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Patent number: 6127356Abstract: The present invention relates, in general, to a method of modulating physiological and pathological processes and, in particular, to a method of modulating intra- and extracellular levels of oxidants and thereby processes in which such oxidants are a participant. The invention also relates to compounds and compositions suitable for use in such methods.Type: GrantFiled: June 7, 1996Date of Patent: October 3, 2000Assignee: Duke UniversityInventors: James D. Crapo, Irwin Fridovich, Tim Oury, Brian J. Day, Rodney J. Folz, Bruce A. Freeman, Michael P. Trova, Ines Batinic-Haberle
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Patent number: 6103714Abstract: The present invention relates, in general, to porphyrin complexes and, in particular, to methods of using porphyrin complexes to impart oxidoreductase activity.Type: GrantFiled: July 24, 1996Date of Patent: August 15, 2000Assignee: Duke UniversityInventors: Irwin Fridovich, Stefan I. Liochev
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Patent number: 5994339Abstract: The present invention relates, in general, to a method of modulating physiological and pathological processes and, in particular, to a method of modulating intra- and extracellular levels of oxidants and thereby processes in which such oxidants are a participant. The invention also relates to compounds and compositions suitable for use in such methods.Type: GrantFiled: June 7, 1995Date of Patent: November 30, 1999Assignees: University of Alabama at Birmingham Research Foundation, Duke UniversityInventors: James D. Crapo, Irwin Fridovich, Tim Oury, Brian J. Day, Rodney J. Folz, Bruce A. Freeman
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Patent number: 5227405Abstract: The invention relates to a water-soluble complex formed between a chelating agent and manganese and pharmaceutical compositions thereof. The complex is a low molecular weight mimic of superoxide dismutase. The invention further relates to a method of using the complex comprising treating plant and animal cells with an amount of the complex sufficient to reduce or prevent superoxide radical-induced toxicity.Type: GrantFiled: September 28, 1988Date of Patent: July 13, 1993Assignee: Duke UniversityInventors: Irwin Fridovich, Douglas J. Darr, Wayne F. Beyer
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Patent number: 5223538Abstract: The invention relates to a water-soluble complex formed between a chelating agent and manganese and pharmaceutical compositions thereof. The complex is a low molecular weight mimic of superoxide dismutase. The invention further relates to a method of using the complex comprising treating plant and animal cells with an amount of the complex sufficient to reduce or prevent superoxide radical-induced toxicity.Type: GrantFiled: March 31, 1987Date of Patent: June 29, 1993Assignee: Duke UniversityInventors: Irwin Fridovich, Douglas J. Darr