Patents by Inventor Irwin H. Krakoff

Irwin H. Krakoff has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 1,2-diaminocyclohexane-platinum complexes with antitumor activity
    Patent number: 5132323
    Abstract: The invention relates to a process for the treatment of tumors in animals with water soluble square-planar cis platinum(II) four-coordinate complexes comprising different nonovalent and divalent organic cations. Monovalent cations include galacturonato and N,N-dimethylglycinato and divalent cations include citraconato, 1,1-cyclobutanedicarboxylato, 1,1-cyclopropanedicarboxylato and Z-iminodiacetato where Z is bound to the nitrogen and is ethyl, propyl, isopropyl, n-butyl, secbutyl, ter-butyl, n-amyl, isoamyl or --OH. The treatment of animals comprises administering to the animals a pharmaceutical composition comprising a platinum complex of the composition described.
    Type: Grant
    Filed: December 20, 1990
    Date of Patent: July 21, 1992
    Assignee: Board of Regents, The University of Texas System
    Inventors: Abdul R. Khokhar, Robert A. Newman, Irwin H. Krakoff
  • 1,2-diaminocyclohexane-platinum complexes with antitumor activity
    Patent number: 5011959
    Abstract: The present invention comprises a water-soluble square-planar cis-platinum(II) four-coordinate complex having the formula:trans-R,R-DACH Pt(II) X.sub.2ortrans-R,R-DACH Pt(II) Ywherein X is a monovalvent cation, two of which are present, selected from the group consisting of cyclopropanecarboxylato, shikimato, saccharatolactone, galacturonato and N,N-dimethyglycinato; wherein Y is a divalent cation selected from the group consisting of citraconato, 1,1-cyclobutanedicarboxylato, 1,1-cyclopropanedicarboxylato, isocitratolactone and Z-iminodiacetato where Z is bound to the nitrogen and is ethyl, propyl, Isopropyl, n-butyl, sec-butyl, ter-butyl, n-amyl, isoamyl or OH.In one preferred aspect the water-soluble square-planar cis-platinum(II) four-coordinate complex has the formula:trans-R,R-DACH Pt(II) X.sub.2wherein X is a monovalent cation. Two X substituents are present in the platinum complex.
    Type: Grant
    Filed: November 17, 1986
    Date of Patent: April 30, 1991
    Assignee: The Board of Regents, The University of Texas System
    Inventors: Abdul R. Khokhar, Robert A. Newman, Irwin H. Krakoff