Abstract: A composition useful for smoothing the skin, reducing wrinkles, and improving the moisture level and tone of the skin having minor proportions of the pharmocologically active agents pregnenolone and elastin in a pharmaceutically acceptable hydrophillic carrier vehicle. The composition may further include substances selected from aloe vera, tocopherols, vegetable, animal and synthetic oils and waxes, allantoin, and skin penetration enhancing agents, such as the lower alkyl sulfoxides.