Patents by Inventor Irwin Kuntz

Irwin Kuntz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Small molecule inhibition of a PDZ-domain interaction
    Publication number: 20080021082
    Abstract: Novel compounds that have been found effective in inhibiting PDZ domain interactions, and particularly interactions of PDZ domains in MAGIs with the oncogenic (tumor suppressor) protein PTEN and interactions between the PDZ domain in the Dishevelled (Dvl) protein and other proteins such as the Frizzled (Fz) protein, have the general formula The invention also includes combinatorial libraries, arrays and methods for screening and studying proteins using such compounds. Compounds of the invention have produced apoptosis in certain cell lines that overexpress the Dishevelled protein (Dvl); inhibiting Wnt signaling.
    Type: Application
    Filed: October 11, 2006
    Publication date: January 24, 2008
    Applicant: The Regents of the University of California
    Inventors: R. Guy, Irwin Kuntz, Jose Haresco, Naoaki Fujii, Kathleen Novak, David Stokoe, Biao He, Liang You, Zhidong Xu, David Jablons
  • Small molecule inhibition of a PDZ-domain interaction
    Publication number: 20050043385
    Abstract: Novel compounds that have been found effective in inhibiting PDZ domain interactions, and particularly interactions of PDZ domains in MAGIs with the oncogenic (tumor suppressor) protein PTEN and interactions between the PDZ domain in the Dishevelled (Dvl) protein and other proteins such as the Frizzled (Fz) protein, have the general formula The invention also includes combinatorial libraries, arrays and methods for screening and studying proteins using such compounds. Compounds of the invention have produced apoptosis in certain cell lines that overexpress the Dishevelled protein (Dvl); inhibiting Wnt signaling.
    Type: Application
    Filed: April 15, 2004
    Publication date: February 24, 2005
    Applicant: The Regents of the University of California
    Inventors: R. Guy, Irwin Kuntz, Jose Haresco, Naoaki Fujii, Kathleen Novak, David Stokoe, Biao He, Liang You, Zhidong Xu, David Jablons