Patents by Inventor Isa K. Mushahwar

Isa K. Mushahwar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Hepatitis B virus surface antigen mutant and methods of detection thereof
    Patent number: 7556815
    Abstract: The subject invention relates to a novel hepatitis B surface antigen mutant and methods of detecting this mutant, and/or antibodies thereto, in patient samples. In particular, the mutant contains a substitution of amino acid threonine for the amino acid alanine at position 123 in the amino acid sequence of the hepatitis B surface antigen (HBsAg) protein.
    Type: Grant
    Filed: February 22, 2007
    Date of Patent: July 7, 2009
    Assignee: Abbott Laboratories Inc.
    Inventors: Paul F. Coleman, Isa K. Mushahwar
  • Hepatitis B virus surface antigen mutant and methods of detection thereof
    Publication number: 20080107672
    Abstract: The subject invention relates to a novel hepatitis B surface antigen mutant and methods of detecting this mutant, and/or antibodies thereto, in patient samples. In particular, the mutant contains a substitution of amino acid threonine for the amino acid alanine at position 123 in the amino acid sequence of the hepatitis B surface antigen (HBsAg) protein.
    Type: Application
    Filed: February 22, 2007
    Publication date: May 8, 2008
    Inventors: Paul F. Coleman, Isa K. Mushahwar
  • Hepatitis B virus surface antigen mutant and methods of detection thereof
    Patent number: 7202354
    Abstract: The subject invention relates to a novel hepatitis B surface antigen mutant and methods of detecting this mutant, and/or antibodies thereto, in patient samples. In particular, the mutant contains a substitution of amino acid threonine for the amino acid alanine at position 123 in the amino acid sequence of the hepatitis B surface antigen (HBsAg) protein.
    Type: Grant
    Filed: March 30, 2001
    Date of Patent: April 10, 2007
    Assignee: Abbott Laboratories
    Inventors: Paul F. Coleman, Isa K. Mushahwar
  • Hepatitis B virus surface antigen mutant and methods of detection thereof
    Patent number: 7141242
    Abstract: The subject invention relates to a novel hepatitis B surface antigen mutant and methods of detecting this mutant, and/or antibodies thereto, in patient samples. In particular, the mutant contains a substitution of amino acid threonine for the amino acid alanine at position 123 in the amino acid sequence of the hepatitis B surface antigen (HBsAg) protein.
    Type: Grant
    Filed: May 17, 2004
    Date of Patent: November 28, 2006
    Assignee: Abbott Laboratories
    Inventors: Paul F. Coleman, Isa K. Mushahwar
  • Hepatitis B virus surface antigen mutant and methods of detection thereof
    Publication number: 20040209248
    Abstract: The subject invention relates to a novel hepatitis B surface antigen mutant and methods of detecting this mutant, and/or antibodies thereto, in patient samples. In particular, the mutant contains a substitution of amino acid threonine for the amino acid alanine at position 123 in the amino acid sequence of the hepatitis B surface antigen (HBsAg) protein.
    Type: Application
    Filed: May 17, 2004
    Publication date: October 21, 2004
    Inventors: Paul F. Coleman, Isa K. Mushahwar
  • Non-a, non-b, non-c, non-c, non-d, non-e hepatitis reagents and methods for their use
    Patent number: 6720166
    Abstract: Hepatitis GB Virus (HGBV) nucleic acid and amino acid sequences useful for a variety of diagnostic and therapeutic applications, kits for using the HGBV nucleic acid or amino acid sequences, HGBV immunogenic particles, and antibodies which specifically bind to HGBV. Also provided are methods for producing antibodies, polyclonal or monoclonal, from the HGBV nucleic acid or amino acid sequences.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: April 13, 2004
    Assignee: Abbott Laboratories
    Inventors: John N. Simons, Tami J. Pilot-Matias, George J. Dawson, George G. Schlauder, Suresh M. Desai, Thomas P. Leary, Anthony Scott Muerhoff, James Carl Erker, Sheri L. Buijk, Isa K. Mushahwar
  • Methods and compositions for detecting hepatitis E virus
    Publication number: 20030211467
    Abstract: Disclosed herein are methods and compositions for detecting the presence in a sample of a US-type or a US-subtype hepatitis E virus, including naturally occurring variants thereof. In particular, the invention provides nucleic acid sequences corresponding to the genome of the US-type or US-subtype hepatitis E virus, amino acid sequences, including epitope sequences, encoded by the genomes of such viruses, and antibodies that bind specifically to such amino acid sequences. The invention further provides methods and compositions for immunizing individuals against infection by, or for treating individuals already infected with such a virus.
    Type: Application
    Filed: December 13, 2002
    Publication date: November 13, 2003
    Inventors: George G. Schlauder, James C. Erker, Suresh M. Desai, George J. Dawson, Isa K. Mushahwar
  • Non-A, non-B, non-C, non-D, non-E hepatitis reagents and methods for their use
    Patent number: 6586568
    Abstract: Hepatitis GB Virus (HGBV) nucleic acid and amino acid sequences useful for a variety of diagnostic and therapeutic applications, kits for using the HGBV nucleic acid or amino acid sequences, HGBV immunogenic particles, and antibodies which specifically bind to HGBV. Also provided are methods for producing antibodies, polyclonal or monoclonal, from the HGBV nucleic acid or amino acid sequences.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: July 1, 2003
    Assignee: Abbott Laboratories
    Inventors: John N. Simons, Tami J. Pilot-Matias, George J. Dawson, George G. Schlauder, Suresh M. Desai, Thomas P. Leary, Anthony Scott Muerhoff, James Carl Erker, Sheri L. Buijk, Isa K. Mushahwar
  • Non-A, non-B, non-C, non-D, non-E hepatitis reagents and methods for their use
    Patent number: 6558898
    Abstract: Hepatitis GB Virus (HGBV) nucleic acid and amino acid sequences useful for a variety of diagnostic and therapeutic applications, kits for using the HGBV nucleic acid or amino acid sequences, HGBV immunogenic particles, and antibodies which specifically bind to HGBV. Also provided are methods for producing antibodies, polyclonal or monoclonal, from the HGBV nucleic acid or amino acid sequences.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: May 6, 2003
    Assignee: Abbott Laboratories
    Inventors: John N. Simons, Tami J. Pilot-Matias, George J. Dawson, George G. Schlauder, Suresh M. Desai, Thomas P. Leary, Anthony Scott Muerhoff, James Carl Erker, Sheri L. Buijk, Isa K. Mushahwar
  • METHODS AND COMPOSITIONS FOR DETECTING HEPATITIS E VIRUS
    Publication number: 20030049601
    Abstract: Disclosed herein are methods and compositions for detecting the presence in a sample of a US-type or a US-subtype hepatitis E virus, including naturally occurring variants thereof. In particular, the invention provides nucleic acid sequences corresponding to the genome of the US-type or US-subtype hepatitis E virus, amino acid sequences, including epitope sequences, encoded by the genomes of such viruses, and antibodies that bind specifically to such amino acid sequences. The invention further provides methods and compositions for immunizing individuals against infection by, or for treating individuals already infected with such a virus.
    Type: Application
    Filed: December 21, 1999
    Publication date: March 13, 2003
    Inventors: GEORGE G. SCHLAUDER, JAMES C. ERKER, SURESH M. DESAI, GEORGE J. DAWSON, ISA K. MUSHAHWAR
  • Hepatitis B virus surface antigen mutant and methods of detection thereof
    Publication number: 20020177124
    Abstract: The subject invention relates to a novel hepatitis B surface antigen mutant and methods of detecting this mutant, and/or antibodies thereto, in patient samples. In particular, the mutant contains a substitution of amino acid threonine for the amino acid alanine at position 123 in the amino acid sequence of the hepatitis B surface antigen (HBsAg) protein.
    Type: Application
    Filed: March 30, 2001
    Publication date: November 28, 2002
    Inventors: Paul F. Coleman, Isa K. Mushahwar
  • Method of performing subtractive hybridization using RDA
    Patent number: 6455255
    Abstract: The subject invention relates to improvements in nucleic acid isolation, and more particularly, relates to modifications to the subtractive hybridization method and to reagents such as oligonucleotides that are useful when performing the method.
    Type: Grant
    Filed: August 2, 2000
    Date of Patent: September 24, 2002
    Assignee: Abbott Laboratories
    Inventors: Larry G. Birkenmeyer, Thomas P. Leary, A. Scott Muerhoff, Suresh M. Desai, Isa K. Mushahwar
  • Non-A, non-B, non-C, non-D, non-E hepatitis reagents and methods for their use
    Patent number: 6451578
    Abstract: Hepatitis GB Virus (HGBV) nucleic acid and amino acid sequences useful for a variety of diagnostic and therapeutic applications, kits for using the HGBV nucleic acid or amino acid sequences, HGBV immunogenic particles, and antibodies which specifically bind to HGBV. Also provided are methods for producing antibodies, polyclonal or monoclonal, from the HGBV nucleic acid or amino acid sequences.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: September 17, 2002
    Assignee: Abbott Laboratories
    Inventors: John N. Simons, Tami J. Pilot-Matias, George J. Dawson, George G. Schlauder, Suresh M. Desai, Thomas P. Leary, Anthony Scott Muerhoff, James Carl Erker, Sheri L. Buijk, Isa K. Mushahwar
  • NON-A,NON-B,NON-C,NON-C,NON-D,NON-E HEPATITIS REAGENTS AND METHODS FOR THEIR USE
    Publication number: 20020119447
    Abstract: Hepatitis GB Virus (HGBV) nucleic acid and amino acid sequences useful for a variety of diagnostic and therapeutic applications, kits for using the HGBV nucleic acid or amino acid sequences, HGBV immunogenic particles, and antibodies which specifically bind to HGBV. Also provided are methods for producing antibodies, polyclonal or monoclonal, from the HGBV nucleic acid or amino acid sequences.
    Type: Application
    Filed: June 5, 1995
    Publication date: August 29, 2002
    Inventors: JOHN N. SIMONS, TAMI J. PILOT-MATIAS, GEORGE J. DAWSON, GEORGE G. SCHLAUDER, SURESH M. DESAI, THOMAS P. LEARY, ANTHONY SCOTT MUERHOFF, JAMES CARL ERKER, SHERI L. BUIJK, ISA K. MUSHAHWAR
  • Methods of utilizing the TT virus
    Publication number: 20010041331
    Abstract: The present invention relates to nucleic oligomer primers or probes useful for detection of TTV in test samples. Also provided are assays which utilize these primers and probes, as well as test kits which contain these oligomer primers and/or. In addition, the present invention encompasses the use of TTV nucleotide sequences as nucleic acid vectors and as markers for determining transmission between individuals as well as the route thereof. Additionally, the present invention invention encompasses a method of detecting TTV infection prior to xenotransplantation of a tissue or organ.
    Type: Application
    Filed: March 23, 2001
    Publication date: November 15, 2001
    Inventors: Thomas P. Leary, James C. Erker, Michelle L. Chalmers, John N. Simons, Larry G. Birkenmeyer, A. Scott Muerhoff, Tami J. Pilot-Matias, Suresh M. Desai, Isa K. Mushahwar
  • Hepatitis GB virus recombinant proteins and uses thereof
    Patent number: 6156495
    Abstract: Recombinantly produced hepatitis GB Virus (HGBV) amino acid sequences useful for a variety of diagnostic and therapeutic applications, kits for using the HGBV amino acid sequences and antibodies which specifically bind to HGBV. Also provided are methods for producing antibodies, polyclonal or monoclonal, from the HGBV recombinantly produced amino acid sequences.
    Type: Grant
    Filed: April 19, 1996
    Date of Patent: December 5, 2000
    Assignee: Abbott Laboratories
    Inventors: Tami J. Pilot-Matias, Thomas P. Leary, John N. Simons, Robert J. Carrick, Teresa K. Surowy, Suresh M. Desai, George J. Dawson, Anthony Scott Muerhoff, Isa K. Mushahwar
  • Non-A, non-B, non-C, non-D, non-E hepatitis reagents and methods for their use
    Patent number: 6051374
    Abstract: Hepatitis GB Virus (HGBV) nucleic acid and amino acid sequences useful for a variety of diagnostic and therapeutic applications, kits for using the HGBV nucleic acid or amino acid sequences, HGBV immunogenic particles, and antibodies which specifically bind to HGBV. Also provided are methods for producing antibodies, polyclonal or monoclonal, from the HGBV nucleic acid or amino acid sequences.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: April 18, 2000
    Assignee: Abbott Laboratories
    Inventors: John N. Simons, Tami J. Pilot-Matias, George J. Dawson, George G. Schlauder, Suresh M. Desai, Thomas P. Leary, Anthony Scott Muerhoff, James Carl Erker, Sheri L. Buijk, Isa K. Mushahwar
  • Non-A, non-B, non-C, non-D, non-E Hepatitis reagents and methods for their use
    Patent number: 5981172
    Abstract: Hepatitus GB Virus (HGBV) nucleic acid and amino acid sequences useful for a variety of diagnostic and theraeutic applications, kits for using the HGBV nucleic acid or amino acid sequences, HGBV immunogenic particles, and antibodies which specifically bind to HGBV. Also provided are methods for producing antibodies, polyclonal or monoclonal, from the HGBV nucleic acid or amino acid sequences.
    Type: Grant
    Filed: April 6, 1995
    Date of Patent: November 9, 1999
    Assignee: Abbott Laboratories
    Inventors: John N. Simons, Tami J. Pilot-Matias, George J. Dawson, George G. Schlauder, Suresh M. Desai, Thomas P. Leary, Anthony Scott Muerhoff, Sheri L. Buijk, James Carl Erker, Isa K. Mushahwar
  • Primer compositions and kits for detecting hepatitis B virus
    Patent number: 5955598
    Abstract: The present invention provides a method for quantitatively detecting the amount of a target nucleic acid sequence which may be present in a test sample. A test sample which may contain a target nucleic acid sequence comprising target sequences X and Y is contacted with two primer sets, the first set being specific for target X and the second set being specific for target Y. The test sample also is contacted at the same time with an internal standard sequence IS, which is substantially derived from a combination of the first and second target sequences, and its corresponding oligonucleotide primers. Haptens are associated with the oligonucleotide primer sets in such a way that amplified target sequence products X and Y are detected by capture on a solid phase to which anti-hapten capture reagents are attached. A signal ratio of (X+Y)/S is determined to quantitate the amount of the target nucleic acid sequence contained in the sample.
    Type: Grant
    Filed: May 28, 1997
    Date of Patent: September 21, 1999
    Assignee: Abbott Laboratories
    Inventors: Larry Birkenmeyer, Isa K. Mushahwar
  • Reagents and methods useful for controlling the translation of hepatitis GBV proteins
    Patent number: 5955318
    Abstract: Reagents and composition for controlling the translation of hepatitis GB virus (HGBV)-A, -B or -C peptides from viral nucleic acid. These reagents and methods comprise control elements of the 5' NTR region of the HGBV-A, -B, or -C viral genome.
    Type: Grant
    Filed: April 19, 1996
    Date of Patent: September 21, 1999
    Assignee: Abbott Laboratories
    Inventors: John N. Simons, Suresh M. Desai, Isa K. Mushahwar