Abstract: A smart underwear (7) system that enables the detection of varicocele disease and the follow-up of varicocele patients, characterized by comprising: at least 2 temperature sensors (5) that enable the temperature of the right and left testicles to be measured, and microcontroller (2), for evaluating the data received from the temperature sensors (5) and, when a certain temperature value is exceeded, warning the user to bring his testicles to the appropriate temperature by means of the vibration motor (3), providing information to the user and/or doctor via SMS and e-mail when the testicular temperature exceeds the specified temperature, transferring and monitoring temperature and disease-related data to the cloud service.