Patents by Inventor Isaac A. Manke

Isaac A. Manke has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MAPKAP kinase-2 as a specific target for blocking proliferation of P53-defective
    Patent number: 9023787
    Abstract: The present invention relates to compounds and pharmaceutical compositions for treating cellular proliferative disorders, e.g., in patients having one or more p53-deficient cells, screening assays for identifying such compounds, and methods for treating such disorders.
    Type: Grant
    Filed: May 13, 2013
    Date of Patent: May 5, 2015
    Assignee: Massachusetts Institute of Technology
    Inventors: Michael B. Yaffe, Isaac A. Manke, Hans Christian Reinhardt
  • Mapkap Kinase-2 as a Specific Target for Blocking Proliferation of P53-Defective Cells
    Publication number: 20140037755
    Abstract: The present invention relates to compounds and pharmaceutical compositions for treating cellular proliferative disorders, e.g., in patients having one or more p53-deficient cells, screening assays for identifying such compounds, and methods for treating such disorders.
    Type: Application
    Filed: May 13, 2013
    Publication date: February 6, 2014
    Applicant: Massachusetts Institute of Technology
    Inventors: Michael B. Yaffe, Isaac A. Manke, Hans Christian Reinhardt
  • Mapkap kinase-2 as a specific target for blocking proliferation of P53-defective cells
    Patent number: 8440610
    Abstract: The present invention relates to compounds and pharmaceutical compositions for treating cellular proliferative disorders, e.g., in patients having one or more p53-deficient cells, screening assays for identifying such compounds, and methods for treating such disorders.
    Type: Grant
    Filed: April 24, 2007
    Date of Patent: May 14, 2013
    Assignee: Massachusetts Institute of Technology
    Inventors: Michael B. Yaffe, Isaac A. Manke, Hans Christian Reinhardt
  • METHODS AND COMPOSITIONS FOR CANCER TREATMENT RELATING TO BRCA1 BRCT DOMAIN RECOGNITION OF PHOSPHORYLATED BACH1
    Publication number: 20120295802
    Abstract: The present invention relates to compounds (e.g., peptidomimetics and non-peptides) that treat, prevent, or stabilize cellular proliferative disorders and methods of treating, preventing, or stabilizing such disorders. The invention also provides three-dimensional structures of a human BRCT domain-BACH1 phosphopeptide complex.
    Type: Application
    Filed: April 19, 2012
    Publication date: November 22, 2012
    Inventors: Michael B. Yaffe, Julie A. Clapperton, Isaac A. Manke, Drew M. Lowery, Stephen J. Smerdon, Lesley F. Haire
  • PRODUCTS AND PROCESSES FOR MODULATING PEPTIDE-PEPTIDE BINDING DOMAIN INTERACTIONS
    Publication number: 20110104713
    Abstract: The present invention relates to therapeutic compounds and methods of use of these therapeutic compounds for treating cellular proliferative disorders. The invention also provides three-dimensional structures of a Polo-like kinase and methods for designing or selecting small molecule inhibitors using these structures, and the therapeutic use of such compounds. The invention also includes a method for identifying novel phosphopeptide-binding domains.
    Type: Application
    Filed: September 29, 2010
    Publication date: May 5, 2011
    Inventors: Michael B. YAFFE, Andrew E. H. Elia, Peter Rellos, Lewis C. Cantley, Stephen J. Smerdon, Isaac Manke
  • Products and processes for modulating peptide-peptide binding domain interactions
    Publication number: 20100030543
    Abstract: The present invention relates to therapeutic compounds and methods of use of these therapeutic compounds for treating cellular proliferative disorders. The invention also provides three-dimensional structures of a Polo-like kinase and methods for designing or selecting small molecule inhibitors using these structures, and the therapeutic use of such compounds. The invention also includes a method for identifying novel phosphopeptide-binding domains.
    Type: Application
    Filed: August 27, 2008
    Publication date: February 4, 2010
    Inventors: Michael B. Yaffe, Andrew E. H. Elia, Peter Rellos, Lewis C. Cantley, Stephen J. Smerdon, Isaac Manke
  • Methods and compositions for treating cellular proliferative diseases
    Publication number: 20090181468
    Abstract: The present invention relates to compounds and pharmaceutical compositions for treating cellular proliferative disorders, screening assays for identifying such compounds, and methods for treating such disorders.
    Type: Application
    Filed: July 24, 2008
    Publication date: July 16, 2009
    Inventors: Michael B. Yaffe, Isaac A. Manke, Hans Christian Reinhardt, Daniel Lim
  • Methods and compositions for cancer treatment relating to BRCA1 BRCT domain recognition of phosphorylated BACH1
    Publication number: 20090143997
    Abstract: The present invention relates to compounds (e.g., peptidomimetics and non-peptides) that treat, prevent, or stabilize cellular proliferative disorders and methods of treating, preventing, or stabilizing such disorders. The invention also provides three-dimensional structures of a human BRCT domain-BACH1 phosphopeptide complex.
    Type: Application
    Filed: August 26, 2008
    Publication date: June 4, 2009
    Inventors: Michael B. Yaffe, Julie A. Clapperton, Isaac A. Manke, Drew M. Lowery, Stephen J. Smerdon, Lesley F. Haire
  • Mapkap kinase-2 as a specific target for blocking proliferation of P53-defective cells
    Publication number: 20090010927
    Abstract: The present invention relates to compounds and pharmaceutical compositions for treating cellular proliferative disorders, e.g., in patients having one or more p53-deficient cells, screening assays for identifying such compounds, and methods for treating such disorders.
    Type: Application
    Filed: April 24, 2007
    Publication date: January 8, 2009
    Inventors: Michael B. Yaffe, Isaac A. Manke, Hans Christian Reinhardt
  • Methods and compositions for treating cellular proliferative diseases
    Publication number: 20060115453
    Abstract: The present invention relates to compounds and pharmaceutical compositions for treating cellular proliferative disorders, screening assays for identifying such compounds, and methods for treating such disorders.
    Type: Application
    Filed: November 14, 2005
    Publication date: June 1, 2006
    Inventors: Michael Yaffe, Isaac Manke, Hans Reinhardt, Daniel Lim
  • Methods and compositions for cancer treatment relating to BRCA1 BRCT domain recognition of phosphorylated BACH1
    Publication number: 20060052951
    Abstract: The present invention relates to compounds (e.g., peptidomimetics and non-peptides) that treat, prevent, or stabilize cellular proliferative disorders and methods of treating, preventing, or stabilizing such disorders. The invention also provides three-dimensional structures of a BRCT domain-BACH1 phosphopeptide complex.
    Type: Application
    Filed: May 9, 2005
    Publication date: March 9, 2006
    Inventors: Michael Yaffe, Julie Clapperton, Isaac Manke, Drew Lowery, Stephen Smerdon
  • Products and processes for modulating peptide-peptide binding domain interactions
    Publication number: 20050196808
    Abstract: The present invention relates to therapeutic compounds and methods of use of these therapeutic compounds for treating cellular proliferative disorders. The invention also provides three-dimensional structures of a Polo-like kinase and methods for designing or selecting small molecule inhibitors using these structures, and the therapeutic use of such compounds. The invention also includes a method for identifying novel phosphopeptide-binding domains.
    Type: Application
    Filed: November 14, 2003
    Publication date: September 8, 2005
    Inventors: Michael Yaffe, Andrew Elia, Peter Rellos, Lewis Cantley, Stephen Smerdon, Isaac Manke