Abstract: A method for estimating locomotion in virtual reality performed by at least one processor includes measuring a plurality of pressure points according to a user's locomotion using a high-resolution tactile sensor including a plurality of pressure sensors, extracting a plurality of footprint images including the plurality of measured pressure points, clustering the plurality of pressure points into a first set of pressure points corresponding to a left foot and a second set of pressure points corresponding to a right foot, based on the plurality of extracted footprint images, and estimating at least a portion of a locomotion direction and a locomotion speed of the user using a first cluster corresponding to the first set of pressure points and a second cluster corresponding to the second set of pressure points.

Abstract: A method for the systemic delivery of an enzyme to treat lysosomal storage disease of a subject is provided by creating genetically modified skin cells via topical introduction of a genetically engineered virus which delivers a nucleic acid encoding an enzyme or factor for expression by the skin cells, wherein the expressed enzyme or factor is secreted by the skin cells and is introduced into the circulatory system of the subject.

Abstract: Electro-anatomically navigated catheters (e.g., mapping catheters, tissue penetrating catheters, delivery catheters and/or sheaths) and associated methods whereby devices or substances may be delivered to specific locations within a patient's body and/or penetration tracts or passageways are formed at specific locations between anatomical structures. The catheters are equipped with sensors and a sensing field is created around the body of the patient. The sensor-equipped catheters are then inserted into the patient's body and the position of the catheter-mounted sensor(s) is/are observed on a display representing the sensing field. Apparatus may be included for propelling the catheter(s) to specific locations and/or specific rotation orientations, within the patient's body.

Abstract: Electro-anatomically navigated catheters (e.g., mapping catheters, tissue penetrating catheters, delivery catheters and/or sheaths) and associated methods whereby devices or substances may be delivered to specific locations within a patient's body and/or penetration tracts or passageways are formed at specific locations between anatomical structures. The catheters are equipped with sensors and a sensing field is created around the body of the patient. The sensor-equipped catheters are then inserted into the patient's body and the position of the catheter-mounted sensor(s) is/are observed on a display representing the sensing field. Apparatus may be included for propelling the catheter(s) to specific locations and/or specific rotation orientations, within the patient's body.