Patents by Inventor Isaac J. Khan
Isaac J. Khan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20200078514Abstract: An apparatus includes a body, a cannula, and a needle. The cannula is flexible and extends distally from the body. The needle is slidably disposed in the cannula. The needle includes a sharp distal tip and a curved portion. The needle is configured to translate relative to the cannula between a proximal position and a distal position. The distal tip is configured to be positioned inside the cannula when the needle is in the proximal position. The distal tip is configured to be positioned outside the cannula when the needle is in the distal position. The needle is resiliently biased to extend along a curve through the curved portion.Type: ApplicationFiled: October 11, 2019Publication date: March 12, 2020Inventors: Thomas E. Meyer, Benjamin L. Ko, Isaac J. Khan, Daniel W. Price, Brendan J. Oberkircher, Michael F. Keane
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Patent number: 10478553Abstract: An apparatus includes a body, a cannula, and a needle. The cannula is flexible and extends distally from the body. The needle is slidably disposed in the cannula. The needle includes a sharp distal tip and a curved portion. The needle is configured to translate relative to the cannula between a proximal position and a distal position. The distal tip is configured to be positioned inside the cannula when the needle is in the proximal position. The distal tip is configured to be positioned outside the cannula when the needle is in the distal position. The needle is resiliently biased to extend along a curve through the curved portion.Type: GrantFiled: February 22, 2017Date of Patent: November 19, 2019Assignee: ORBIT BIOMEDICAL LIMITEDInventors: Thomas E. Meyer, Benjamin L. Ko, Isaac J. Khan, Daniel W. Price, Brendan J. Oberkircher, Michael F. Keane
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Publication number: 20190183674Abstract: A system for storing and delivering a predetermined amount of fluid includes a syringe including a barrel, a flange disposed at the proximal end of the barrel, and a plunger assembly configured to be received in the lumen of the barrel. The plunger assembly includes a piston and a plunger rod. The plunger rod is removably couplable to the piston at the distal end of the plunger rod and includes a thumb press flange at the proximal end of the plunger rod. The system further includes a stop feature that is removably couplable to the syringe or the plunger assembly. The stop feature is configured to arrest distal advancement of the plunger assembly relative to the syringe when the plunger assembly reaches a predetermined position relative to the syringe. The stop thus ensures that a predetermined amount of fluid remains in the barrel.Type: ApplicationFiled: February 25, 2019Publication date: June 20, 2019Inventors: Mark C. Tsai, Brian M. Gatton, JR., Michael F. Keane, Isaac J. Khan, Brendan J. Oberkircher, Daniel W. Price
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Publication number: 20190142634Abstract: An apparatus for delivering therapeutic agent to an eye comprises a body, a cannula, a hollow needle, and an actuation assembly. The cannula extends distally from the body and is sized and configured to be insertable between a choroid and a sclera of a patient's eye. The actuation assembly is operable to actuate the needle relative to the cannula to thereby drive a distal portion of the needle along an exit axis that is obliquely oriented relative to the longitudinal axis of the cannula. The cannula may be inserted through a sclerotomy incision to position a distal end of the cannula at a posterior region of the eye, between the choroid and sclera. The needle may be advanced through the choroid to deliver the therapeutic agent adjacent to the potential space between the neurosensory retina and the retinal pigment epithelium layer, adjacent to the area of geographic atrophy.Type: ApplicationFiled: November 8, 2018Publication date: May 16, 2019Inventors: Brendan J. Oberkircher, Daniel W. Price, Michael F. Keane, Saeed Sokhanvar, Daniel J. Yasevac, Michel G. Bruehwiler, Leah R. Soffer, Isaac J. Khan, Benjamin L. Ko, Christopher D. Riemann, Nathan D. Grubbs
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Publication number: 20190142635Abstract: An apparatus for delivering therapeutic agent to an eye comprises a body, a cannula, a hollow needle, and an actuation assembly. The cannula extends distally from the body and is sized and configured to be insertable between a choroid and a sclera of a patient's eye. The actuation assembly is operable to actuate the needle relative to the cannula to thereby drive a distal portion of the needle along an exit axis that is obliquely oriented relative to the longitudinal axis of the cannula. The cannula may be inserted through a sclerotomy incision to position a distal end of the cannula at a posterior region of the eye, between the choroid and sclera. The needle may be advanced through the choroid to deliver the therapeutic agent adjacent to the potential space between the neurosensory retina and the retinal pigment epithelium layer, adjacent to the area of geographic atrophy.Type: ApplicationFiled: November 8, 2018Publication date: May 16, 2019Inventors: Brendan J. Oberkircher, Daniel W. Price, Michael F. Keane, Saeed Sokhanvar, Daniel J. Yasevac, Michel G. Bruehwiler, Leah R. Soffer, Isaac J. Khan, Benjamin L. Ko, Christopher D. Riemann, Nathan D. Grubbs
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Patent number: 10258502Abstract: A system for storing and delivering a predetermined amount of fluid includes a syringe including a barrel, a flange disposed at the proximal end of the barrel, and a plunger assembly configured to be received in the lumen of the barrel. The plunger assembly includes a piston and a plunger rod. The plunger rod is removably couplable to the piston at the distal end of the plunger rod and includes a thumb press flange at the proximal end of the plunger rod. The system further includes a stop feature that is removably couplable to the syringe or the plunger assembly. The stop feature is configured to arrest distal advancement of the plunger assembly relative to the syringe when the plunger assembly reaches a predetermined position relative to the syringe. The stop thus ensures that a predetermined amount of fluid remains in the barrel.Type: GrantFiled: September 2, 2015Date of Patent: April 16, 2019Assignee: ORBIT BIOMEDICAL LIMITEDInventors: Mark C. Tsai, Brian M. Gatton, Jr., Michael F. Keane, Isaac J. Khan, Brendan J. Oberkircher, Daniel W. Price
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Patent number: 10226379Abstract: An apparatus for delivering therapeutic agent to an eye includes a body, a cannula, a hollow needle, and an actuation assembly. The cannula extends distally from the body and is sized and configured to be insertable between a choroid and a sclera of a patient's eye. The actuation assembly is operable to actuate the needle relative to the cannula to thereby drive a distal portion of the needle along an exit axis that is obliquely oriented relative to the longitudinal axis of the cannula. The cannula may be inserted through a sclerotomy incision to position a distal end of the cannula at a posterior region of the eye, between the choroid and sclera. The needle may be advanced through the choroid to deliver the therapeutic agent adjacent to the potential space between the neurosensory retina and the retinal pigment epithelium layer, adjacent to the area of geographic atrophy.Type: GrantFiled: February 11, 2015Date of Patent: March 12, 2019Assignee: ORBIT BIOMEDICAL LIMITEDInventors: Brendan J. Oberkircher, Daniel W. Price, Michael F. Keane, Saeed Sokhanvar, Daniel J. Yasevac, Michel G. Bruehwiler, Leah R. Soffer, Isaac J. Khan, Benjamin L. Ko, Christopher D. Riemann, Nathan D. Grubbs
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Patent number: 10219936Abstract: An apparatus for delivering therapeutic agent to an eye comprises a body, a cannula, a hollow needle, a cannula actuation assembly, and a needle actuation assembly. The cannula extends distally from the body and is sized and configured to be insertable between a choroid and a sclera of a patient's eye. The cannula actuation assembly is operable to actuate the cannula relative to the body. The needle actuation assembly is operable to actuate the needle relative to the cannula. The cannula may be inserted through a sclerotomy to position a distal end of the cannula at a posterior region of the eye, between the choroid and sclera. The needle may be advanced through the choroid to deliver the therapeutic agent adjacent to the potential space between the neurosensory retina and the retinal pigment epithelium layer, adjacent to the area of geographic atrophy.Type: GrantFiled: August 31, 2015Date of Patent: March 5, 2019Assignee: ORBIT BIOMEDICAL LIMITEDInventors: Benjamin L. Ko, Robert H. Roth, Thomas E. Meyer, Paul D. Gordon, Isaac J. Khan, Daniel W. Price, Brendan J. Oberkircher
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Publication number: 20180289540Abstract: An apparatus has a first fluid conduit, a second fluid conduit, a connector member, an first tubular member, a second tubular member, and an inner cannula. The connector member has first and second passageways in which the first and second fluid conduits are positioned, respectively. A portion of the second tubular member is positioned within the lumen of the first tubular member. A proximal portion of the inner cannula is fixedly secured within the lumen of the first tubular member. The inner cannula lumen is in fluid communication with the first and second fluid conduits via the lumen of the first tubular member and the lumen of the second tubular member. The inner cannula may be inserted into the subretinal space of a human eye to deliver a leading bleb of fluid and then deliver a therapeutic agent, without having to withdraw the inner cannula from the subretinal space between the acts of delivering the leading bleb delivering the therapeutic agent.Type: ApplicationFiled: March 19, 2018Publication date: October 11, 2018Inventors: Joseph H. Contiliano, Thomas E. Meyer, Daniel J. Abbott, Michael F. Keane, Allen C. Ho, Mark C. Tsai, Isaac J. Khan
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Publication number: 20180256394Abstract: A method includes inserting a flexible cannula between a sclera and a choroid of an eye. The needle is advanced from a distal end of the flexible cannula, such that the needle pierces the choroid to access a subretinal space of the eye. The needle is used to aspirate fluid from the subretinal space. The fluid may be present from a retinal detachment, a macular hemorrhage, or other condition present before the procedure begins. The method may further include injecting the fluid in the subretinal space via the needle, in which case the fluid may be a balanced salt solution or other bleb fluid. The method may further include injecting a therapeutic agent into the subretinal space after aspirating the bleb fluid. The volume of injected bleb fluid may be greater than the volume of injected therapeutic agent.Type: ApplicationFiled: March 5, 2018Publication date: September 13, 2018Inventors: Daniel W. Price, Brendan J. Oberkircher, Daniel J. Prenger, Geoffrey King, Isaac J. Khan, Michael F. Keane, Benjamin L. Ko
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Patent number: 10064752Abstract: An apparatus for delivering therapeutic agent to an eye comprises a body, a cannula, a hollow needle, and an automated actuation assembly. The cannula extends distally from the body and is sized and configured to be insertable between a choroid and a sclera of a patient's eye. The actuation assembly is operable to actuate the needle relative to the cannula to thereby drive a distal portion of the needle along an exit axis that is obliquely oriented relative to the longitudinal axis of the cannula. The cannula may be inserted through a sclerotomy to position a distal end of the cannula at a posterior region of the eye, between the choroid and sclera. The needle may be advanced through the choroid to deliver the therapeutic agent adjacent to the potential space between the neurosensory retina and the retinal pigment epithelium layer, adjacent to the area of geographic atrophy.Type: GrantFiled: August 31, 2015Date of Patent: September 4, 2018Assignee: ORBIT BIOMEDICAL LIMITEDInventors: Daniel W. Price, Isaac J. Khan, Brendan J. Oberkircher, Saeed Sokhanvar, Daniel J. Yasevac, Michel Bruehwiler, Leah R. Soffer, Mohammadreza Ramerzanifard, Mary Carter
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Publication number: 20180200108Abstract: An apparatus includes a body, a cannula, a conduit, and a magnetic element. The cannula extends distally from the body. The cannula is flexible and has a distal end. The cannula defines a lumen distally terminating at the distal end. The cannula is sized and configured to pass between a sclera layer and a choroid layer in a human eye. The conduit is in fluid communication with the lumen. The magnetic element is positioned in the body.Type: ApplicationFiled: January 9, 2018Publication date: July 19, 2018Inventors: Daniel W. Price, Brendan J. Oberkircher, Daniel J. Prenger, Geoffrey King, Isaac J. Khan, Michael F. Keane
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Patent number: 9949874Abstract: An apparatus has a first fluid conduit, a second fluid conduit, a connector member, an first tubular member, a second tubular member, and an inner cannula. The connector member has first and second passageways in which the first and second fluid conduits are positioned, respectively. A portion of the second tubular member is positioned within the lumen of the first tubular member. A proximal portion of the inner cannula is fixedly secured within the lumen of the first tubular member. The inner cannula lumen is in fluid communication with the first and second fluid conduits via the lumen of the first tubular member and the lumen of the second tubular member. The inner cannula may be inserted into the subretinal space of a human eye to deliver a leading bleb of fluid and then deliver a therapeutic agent, without having to withdraw the inner cannula from the subretinal space between the acts of delivering the leading bleb delivering the therapeutic agent.Type: GrantFiled: June 1, 2015Date of Patent: April 24, 2018Assignee: Janssen Biotech, Inc.Inventors: Joseph H. Contiliano, Thomas E. Meyer, Daniel J. Abbott, Michael F. Keane, Allen C. Ho, Mark C. Tsai, Isaac J. Khan
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Publication number: 20170360605Abstract: An apparatus includes a body and a pair of rigid legs extending from the body. The body includes an engagement feature configured to engage a deployment instrument. The legs are parallel with each other. Each leg has a sharp tip. The legs both extend along a plane. The body defines a guide opening. The guide opening is oriented transversely relative to the plane associated with the legs. The guide opening is sized to receive a cannula having a generally flat profile. The guide opening is configured to guide the cannula through a sclerotomy at a substantially tangential orientation.Type: ApplicationFiled: May 31, 2017Publication date: December 21, 2017Inventors: Brendan J. Oberkircher, Benjamin L. Ko, Robert H. Roth, Mark S. Ortiz, Thomas E. Meyer, Franklin S. Busch, Isaac J. Khan, Michael F. Keane, Anna R. Raymond, Jacob W. Schubert
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Publication number: 20170360606Abstract: An apparatus includes a pad assembly, an injector assembly, an injector driver, and a fluid source. The pad assembly is sized and configured to be placed on a forehead of a patient. The injector assembly includes a body, a flexible cannula, and a needle. The body is configured to be removably secured to the pad assembly. The cannula is sized to be inserted through an incision in an eye of a patient. The needle is slidably disposed in the cannula. The injector driver is operable to drive the needle longitudinally relative to the flexible cannula. The fluid source assembly is in fluid communication with the needle.Type: ApplicationFiled: May 31, 2017Publication date: December 21, 2017Inventors: Daniel W. Price, Brendan J. Oberkircher, James G. Lee, Clinton Denlinger, Daniel J. Prenger, Geoffrey King, Scott Uhland, Mark C. Tsai, Michael F. Keane, Isaac J. Khan, Benjamin L. Ko, Thomas E. Meyer, Denis P. Turner
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Publication number: 20170258988Abstract: An apparatus includes a body, a cannula, and a needle. The cannula is flexible and extends distally from the body. The needle is slidably disposed in the cannula. The needle includes a sharp distal tip and a curved portion. The needle is configured to translate relative to the cannula between a proximal position and a distal position. The distal tip is configured to be positioned inside the cannula when the needle is in the proximal position. The distal tip is configured to be positioned outside the cannula when the needle is in the distal position. The needle is resiliently biased to extend along a curve through the curved portion.Type: ApplicationFiled: February 22, 2017Publication date: September 14, 2017Inventors: Thomas E. Meyer, Benjamin L. Ko, Isaac J. Khan, Daniel W. Price, Brendan J. Oberkircher, Michael F. Keane
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Publication number: 20160081849Abstract: A system for storing and delivering a predetermined amount of fluid includes a syringe including a barrel, a flange disposed at the proximal end of the barrel, and a plunger assembly configured to be received in the lumen of the barrel. The plunger assembly includes a piston and a plunger rod. The plunger rod is removably couplable to the piston at the distal end of the plunger rod and includes a thumb press flange at the proximal end of the plunger rod. The system further includes a stop feature that is removably couplable to the syringe or the plunger assembly. The stop feature is configured to arrest distal advancement of the plunger assembly relative to the syringe when the plunger assembly reaches a predetermined position relative to the syringe. The stop thus ensures that a predetermined amount of fluid remains in the barrel.Type: ApplicationFiled: September 2, 2015Publication date: March 24, 2016Inventors: Mark C. Tsai, Brian M. Gatton, JR., Michael F. Keane, Isaac J. Khan, Brendan J. Oberkircher, Daniel W. Price
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Publication number: 20160074217Abstract: An apparatus for delivering therapeutic agent to an eye comprises a body, a cannula, a hollow needle, and an automated actuation assembly. The cannula extends distally from the body and is sized and configured to be insertable between a choroid and a sclera of a patient's eye. The actuation assembly is operable to actuate the needle relative to the cannula to thereby drive a distal portion of the needle along an exit axis that is obliquely oriented relative to the longitudinal axis of the cannula. The cannula may be inserted through a sclerotomy to position a distal end of the cannula at a posterior region of the eye, between the choroid and sclera. The needle may be advanced through the choroid to deliver the therapeutic agent adjacent to the potential space between the neurosensory retina and the retinal pigment epithelium layer, adjacent to the area of geographic atrophy.Type: ApplicationFiled: August 31, 2015Publication date: March 17, 2016Inventors: Daniel W. Price, Isaac J. Khan, Brendan J. Oberkircher, Saeed Sokhanvar, Daniel J. Yasevac, Michel Bruehwiler, Leah R. Soffer, Reza Fard, Mary Carter
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Publication number: 20160074211Abstract: An apparatus for delivering therapeutic agent to an eye comprises a body, a cannula, a hollow needle, a cannula actuation assembly, and a needle actuation assembly. The cannula extends distally from the body and is sized and configured to be insertable between a choroid and a sclera of a patient's eye. The cannula actuation assembly is operable to actuate the cannula relative to the body. The needle actuation assembly is operable to actuate the needle relative to the cannula. The cannula may be inserted through a sclerotomy to position a distal end of the cannula at a posterior region of the eye, between the choroid and sclera. The needle may be advanced through the choroid to deliver the therapeutic agent adjacent to the potential space between the neurosensory retina and the retinal pigment epithelium layer, adjacent to the area of geographic atrophy.Type: ApplicationFiled: August 31, 2015Publication date: March 17, 2016Inventors: Benjamin L. Ko, Robert H. Roth, Thomas E. Meyer, Paul D. Gordon, Isaac J. Khan, Daniel W. Price, Brendan J. Oberkircher
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Publication number: 20150351958Abstract: An apparatus has a first fluid conduit, a second fluid conduit, a connector member, an first tubular member, a second tubular member, and an inner cannula. The connector member has first and second passageways in which the first and second fluid conduits are positioned, respectively. A portion of the second tubular member is positioned within the lumen of the first tubular member. A proximal portion of the inner cannula is fixedly secured within the lumen of the first tubular member. The inner cannula lumen is in fluid communication with the first and second fluid conduits via the lumen of the first tubular member and the lumen of the second tubular member. The inner cannula may be inserted into the subretinal space of a human eye to deliver a leading bleb of fluid and then deliver a therapeutic agent, without having to withdraw the inner cannula from the subretinal space between the acts of delivering the leading bleb delivering the therapeutic agent.Type: ApplicationFiled: June 1, 2015Publication date: December 10, 2015Inventors: Joseph H. Contiliano, Thomas E. Meyer, Daniel J. Abbott, Michael F. Keane, Allen C. Ho, Mark C. Tsai, Isaac J. Khan