Patents by Inventor Isaac J. Powell

Isaac J. Powell has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions and methods relating to inhibitors of pro-inflammatory factors for treatment of cancer
    Patent number: 11931360
    Abstract: Compositions and methods for treatment of cancer according to aspects of the present disclosure comprise compounds comprising or consisting of: structural formula (I) or (II) disclosed herein, or a salt, isomer, or derivative thereof.
    Type: Grant
    Filed: June 23, 2022
    Date of Patent: March 19, 2024
    Assignee: Wayne State University
    Inventors: Isaac J. Powell, Navnath S. Gavande
  • COMPOSITIONS AND METHODS RELATING TO INHIBITORS OF PRO-INFLAMMATORY FACTORS FOR TREATMENT OF CANCER
    Publication number: 20230018174
    Abstract: Compositions and methods for treatment of cancer according to aspects of the present disclosure comprise compounds comprising or consisting of: structural formula (I) or (II) disclosed herein, or a salt, isomer, or derivative thereof.
    Type: Application
    Filed: June 23, 2022
    Publication date: January 19, 2023
    Inventors: Isaac J. Powell, Navnath S. Gavande
  • Prostate cancer aggressiveness gene signatures for subjects of African or European descent
    Patent number: 11332794
    Abstract: The use of genes or biomarkers to more accurately diagnose aggressive prostate cancer in men of African descent or European descent is provided. More specifically, the genes or biomarkers of the present invention can be used in diagnostic tests and methods to determine, qualify, and/or assess aggressive prostate cancer or status, for example, to diagnose or identify aggressive prostate cancer, in an individual, subject, or patient, such as men of African descent or men of European descent.
    Type: Grant
    Filed: January 19, 2017
    Date of Patent: May 17, 2022
    Assignee: Wayne State University
    Inventors: Isaac J. Powell, Aliccia Bollig-Fischer, Greg Dyson
  • COMPOSITIONS AND METHODS RELATING TO INHIBITORS OF PRO-INFLAMMATORY CYTOKINES AND CHEMOKINES FOR TREATMENT OF CANCER
    Publication number: 20210285951
    Abstract: Methods of treatment of cancer, including prostate cancer, in a subject in need thereof are provided according to aspects of the present disclosure which include administering an effective amount of an inhibitor of a pro-inflammatory factor to the subject, wherein the pro-inflammatory factor is dysregulated in the subject, and wherein the inhibitor is an inhibitor of a pro-inflammatory factor selected from the group consisting of: interleukin-1?, interleukin-6, interleukin-8, interleukin-10, stromal cell-derived factor-1?, matrix metallopeptidase 9, epithelial-derived neutrophil-activating peptide 78, receptor for advanced glycation end products, TNF-?, HER2, CXCR4, and leptin. Assays of these factors, or subsets thereof, provide a pro-inflammatory cytokine score useful in determining a characteristic of the cancer, particularly aggressiveness.
    Type: Application
    Filed: March 12, 2021
    Publication date: September 16, 2021
    Inventor: Isaac J. Powell
  • PROSTATE CANCER AGGRESSIVENESS GENE SIGNATURES FOR SUBJECTS OF AFRICAN OR EUROPEAN DECENT
    Publication number: 20210062267
    Abstract: The use of genes or biomarkers to more accurately diagnose aggressive prostate cancer in men of African descent or European descent is provided. More specifically, the genes or biomarkers of the present invention can be used in diagnostic tests and methods to determine, qualify, and/or assess aggressive prostate cancer or status, for example, to diagnose or identify aggressive prostate cancer, in an individual, subject, or patient, such as men of African descent or men of European descent.
    Type: Application
    Filed: January 19, 2017
    Publication date: March 4, 2021
    Inventors: Isaac J. Powell, Aliccia Bollig-Fischer, Greg Dyson