Patents by Inventor Isaac Klein

Isaac Klein has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SYNTHESIS OF COVALENT PROTEIN DIMERS THAT CAN INHIBIT MYC-DRIVEN TRANSCRIPTION
    Publication number: 20240336649
    Abstract: The disclosure relates to covalent protein dimers of MYC, MAX, and Omomyc; pharmaceutical compositions comprising the covalent protein dimers; methods of making the covalent protein dimers; and methods of treating disorders associated with MYC dysregulation (e.g., cancer) with the covalent protein dimers.
    Type: Application
    Filed: June 17, 2022
    Publication date: October 10, 2024
    Inventors: ANDREI LOAS, BRADLEY L. PENTELUTE, SEBASTIAN POMPLUN, MUHAMMAD JBARA, CARLY KATHERINE SCHISSEL, JACOB JOSHUA LEE RODRIQUEZ, STEPHEN LEFFLER BUCHWALD, ANN BOIJA, ISAAC KLEIN, SUSANA WILSON HAWKEN, CHARLES HAN LI
  • VIRAL CONDENSATES AND METHODS OF USE THEREOF
    Publication number: 20230236190
    Abstract: Provided herein are methods of screening for agents that can partition in viral condensates and therefore may be effective anti-viral agents. Also disclosed are methods of optimizing the activity and reducing the side effects of known or suspected anti-viral agents by screening the portioning of modified known or suspected anti-viral agents in viral condensates and other condensates occurring in cells (e.g., transcriptional condensates).
    Type: Application
    Filed: June 21, 2021
    Publication date: July 27, 2023
    Inventors: Richard A. Young, Isaac Klein, Ann Boija, Ozgur Oksuz
  • METHODS OF CHARACTERIZING AND UTILIZING AGENT-CONDENSATE INTERACTIONS
    Publication number: 20220390432
    Abstract: Described herein are methods of characterizing agent incorporation into condensates, methods of reducing transcription of oncogenes associated with condensates, and methods of using peptides to inhibit nuclear receptor and cofactor binding in condensates.
    Type: Application
    Filed: May 15, 2020
    Publication date: December 8, 2022
    Inventors: Richard A. Young, Ann Boija, Isaac Klein
  • METHODS AND ASSAYS FOR MODULATING GENE TRANSCRIPTION BY MODULATING CONDENSATES
    Publication number: 20220120736
    Abstract: Described herein are compositions and methods for modulating gene regulation by modulating condensate formation, composition, maintenance, dissolution and regulation.
    Type: Application
    Filed: March 22, 2019
    Publication date: April 21, 2022
    Inventors: Richard A. Young, Phillip A. Sharp, Arup K. Chakraborty, Alessandra Dall'Agnese, Krishna Shrinivas, Brian J. Abraham, Ann Boija, Eliot Coffey, Daniel S. Day, Yang E. Guo, Nancy M. Hannett, Tong Ihn Lee, Charles H. Li, Isaac Klein, John C. Manteiga, Benjamin R. Sabari, Jurian Schuijers, Abraham S. Weintraub, Alicia V. Zamudio, Lena K. Afeyan, Ozgur Oksuz, Jonathan E. Henninger