Abstract: A method for detection of an evoked response signal in noise including: generating a plurality of stimuli; receiving a noisy signal related to an evoked response to the plurality of stimuli; divide the noisy signal into a plurality of responses to the plurality of stimuli; estimate a statistic matrix for the plurality of responses; shrink the statistic matrix; calculate weights based on an inverse of the shrunk statistic matrix; apply weights to the plurality of responses to construct a final response; and output the final response. An apparatus having an input device configured to receive data related to a plurality of stimuli; and a processor configured to: receive a noisy signal and divide the noisy signal into a plurality of responses; estimate a statistic matrix; shrink the statistic matrix; calculate weights based on an inverse of the shrunk statistic matrix; and apply weights to the plurality of responses to construct a final response.

Abstract: A method for detection of an evoked response signal in noise including: generating a plurality of stimuli; receiving a noisy signal related to an evoked response to the plurality of stimuli; divide the noisy signal into a plurality of responses to the plurality of stimuli; estimate a statistic matrix for the plurality of responses; shrink the statistic matrix; calculate weights based on an inverse of the shrunk statistic matrix; apply weights to the plurality of responses to construct a final response; and output the final response. An apparatus having an input device configured to receive data related to a plurality of stimuli; and a processor configured to: receive a noisy signal and divide the noisy signal into a plurality of responses; estimate a statistic matrix; shrink the statistic matrix; calculate weights based on an inverse of the shrunk statistic matrix; and apply weights to the plurality of responses to construct a final response.

Abstract: A system and method for filtering a signal comprising: receiving a signal of interest; receiving a signal indicating that a stimulus has been applied; receiving the synchronized stimulus signal and signal of interest; recursively selecting a portion of the signal of interest associated with a stimulus being applied and assign the selected portion of the signal of interest to one of the plurality of buffers; combining all responses in each of said plurality of buffers; transforming the combination of all responses in each buffer to a transform space; comparing the transform components of the buffers to determine a scaling factor; applying the scaling factor to the spectral components of the buffers; performing an inverse transform on the result of combining the buffers to return to the time domain to produce a filtered signal, and outputting the filtered signal received from the processor.

Abstract: An apparatus, method and system for collection of physiological electrical potential signals. In one embodiment, an apparatus for use in measuring electrical potentials in a subject (e.g. an animal or a human), having an amplifier being removably mountable to a ground electrode and electrically coupled to at least two signal electrodes, wherein the amplifier is configured to communicate with a signal processing device and indicate if one of the at least two signal electrodes is poorly affixed to, or detached from, said subject. In another embodiment, the at least two signal electrodes comprise a first signal electrode and a second signal electrode, and the amplifier is configured to detect differential electrical potential signals presented by the first signal electrode and the second signal electrode, amplify the differential electrical potential signals by a predetermined gain level to generate an amplified signal, and transmit the amplified signal to the signal processing device.

Abstract: A system and method for filtering a signal comprising: receiving a signal of interest; receiving a signal indicating that a stimulus has been applied; receiving the synchronized stimulus signal and signal of interest; recursively selecting a portion of the signal of interest associated with a stimulus being applied and assign the selected portion of the signal of interest to one of the plurality of buffers; combining all responses in each of said plurality of buffers; transforming the combination of all responses in each buffer to a transform space; comparing the transform components of the buffers to determine a scaling factor; applying the scaling factor to the spectral components of the buffers; performing an inverse transform on the result of combining the buffers to return to the time domain to produce a filtered signal, and outputting the filtered signal received from the processor.

Abstract: An apparatus, method and system for collection of physiological electrical potential signals. In one embodiment, an apparatus for use in measuring electrical potentials in a subject (e.g. an animal or a human), having an amplifier being removably mountable to a ground electrode and electrically coupled to at least two signal electrodes, wherein the amplifier is configured to communicate with a signal processing device and indicate if one of the at least two signal electrodes is poorly affixed to, or detached from, said subject. In another embodiment, the at least two signal electrodes comprise a first signal electrode and a second signal electrode, and the amplifier is configured to detect differential electrical potential signals presented by the first signal electrode and the second signal electrode, amplify the differential electrical potential signals by a predetermined gain level to generate an amplified signal, and transmit the amplified signal to the signal processing device.

Abstract: A system and method for filtering and detecting faint signals in noise by placing a filter prior to an amplifier. In particular, a system for filtering differential signals includes: a signal receiver for receiving a differential signal; a prefiltering network connected to the receiver for filtering the differential signal prior to amplification, the prefiltering network including a high-pass filter and/or a low-pass filter; and an amplifier connected to the filtering network. In contrast with the conventional approach of connecting the filter to the amplifier's inputs, the filtering network in a preferred embodiment of the invention is connected to the amplifier through the amplifier's gain resistor such that the input impedance and common mode rejection ratio of the amplifier is not adversely affected by the filtering. Band-pass filtering prior to amplification reduces the noise in the signal and allows higher gain to provide a clearer signal following amplification.

Abstract: An invention is disclosed that provides an apparatus, method and system for the collection of physiological electrical potential signals. In one embodiment, the apparatus comprises integrating amplifier and an electrode into a combined unit for attaching or affixing to a subject (e.g., an animal or a human). Resulting from the extremely small or short connection between the conductive portion of the electrode and the amplifier, significantly less noise is introduced into the signal detected by the amplifier. The amplifier thus amplifies a signal with a much higher signal-to-noise ratio as compared with conventional electrode to lead wire to amplifier arrangements.

Abstract: A method of providing simplified keyed access to a computer or to other electronic devices with an alphabetic display, also referred to as a "computer", the method including the use of a low order hashing code for hashing the vocabulary in the computer, then using the same hashing code to hash-code a desired word that a user wishes the computer to display; entering the hash-coded word, and comparing the desired word with vocabulary words that conform to the code. To specify a desired word from among the vocabulary words that match the hash code, the vocabulary, or portions thereof, are preferably organized as a binary tree, having the words with highest frequency of use located highest in the tree. Where a binary hashing code is used, then the alphabet is approximately halved, such as at the letter N, and a simple key code such as a Dot can be used to denote all letters in the group A through M, and a Dash can be used to denote all letters in the group N through Z.