Patents by Inventor Isaac MARKS

Isaac MARKS has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ANTIBODY-OLIGONUCLEOTIDE CONJUGATE COMPOSITIONS AND METHODS OF INDUCING DMD EXON 45 SKIPPING
    Publication number: 20250121085
    Abstract: Disclosed herein are binding moiety (e.g., antibody)-oligonucleotide (e.g., PMO) conjugates and pharmaceutical compositions that induce an alteration in an incorrectly spliced dystrophin mRNA transcript to induce DMD exon 45 skipping. Also described herein include methods for treating muscle dystrophy including Duchenne muscular dystrophy that comprises administering such conjugates or a pharmaceutical composition that induces alteration in an incorrectly spliced dystrophin mRNA transcript to induce DMD exon 45 skipping.
    Type: Application
    Filed: October 1, 2024
    Publication date: April 17, 2025
    Inventors: Beatrice Diana DARIMONT, Usue ETXANIZ IRIGOIEN, Venkata Ramana DOPPALAPUDI, Michael Caramian COCHRAN, Isaac MARKS, Tyler ALBIN
  • ANTI-TRANSFERRIN RECEPTOR ANTIBODY-PMO CONJUGATES FOR INDUCING DMD EXON 44 SKIPPING
    Publication number: 20240368598
    Abstract: Disclosed herein are antibody oligonucleotide conjugates and pharmaceutical compositions that induce an alteration in an incorrectly spliced dystrophin mRNA transcript to induce exon 44 skipping. Also described herein include methods for treating muscle dystrophy including Duchenne muscular dystrophy that comprises administering antibody oligonucleotide conjugates or a pharmaceutical composition that induces alteration in an incorrectly spliced dystrophin mRNA transcript to induce exon 44 skipping.
    Type: Application
    Filed: July 15, 2024
    Publication date: November 7, 2024
    Inventors: Beatrice Diana DARIMONT, Usue ETXANIZ IRIGOIEN, Venkata Ramana DOPPALAPUDI, Michael Caramian COCHRAN, Isaac MARKS, Tyler ALBIN
  • ANTIBODY OLIGONUCLEOTIDE CONJUGATE COMPOSITIONS AND METHODS OF INDUCING DMD EXON 44 SKIPPING
    Publication number: 20230364256
    Abstract: Disclosed herein are antibody oligonucleotide conjugates and pharmaceutical compositions that induce an alteration in an incorrectly spliced dystrophin mRNA transcript to induce exon 44 skipping. Also described herein include methods for treating muscle dystrophy including Duchenne muscular dystrophy that comprises administering antibody oligonucleotide conjugates or a pharmaceutical composition that induces alteration in an incorrectly spliced dystrophin mRNA transcript to induce exon 44 skipping.
    Type: Application
    Filed: April 4, 2023
    Publication date: November 16, 2023
    Inventors: Beatrice Diana DARIMONT, Usue ETXANIZ IRIGOIEN, Venkata Ramana DOPPALAPUDI, Michael Caramian COCHRAN, Isaac MARKS, Tyler ALBIN