Abstract: An interactive mixed reality simulator is provided that includes a virtual 3D model of internal or hidden features of an object; a physical model or object being interacted with; and a tracked instrument used to interact with the physical object. The tracked instrument can be used to simulate or visualize interactions with internal features of the physical object represented by the physical model. In certain embodiments, one or more of the internal features can be present in the physical model. In another embodiment, some internal features do not have a physical presence within the physical model.

Abstract: Systems, methods, and computer program products for determining a location from non-line-of-sight (NLOS) signals are described. A processor can determine that multipath interferences of a signal reaching a receiver through different paths that are close in lengths may be mistakenly interpreted as additional time shift, (e.g., additional time delay or, in some cases, time advance) of the signal in calculating a timing of the signal. The processor can determine the possible differences between path lengths and then determine an amount of the additional time shift. The processor can determine a shift correction to remove effects caused by the additional time delay from the timing calculation.

Abstract: Systems, methods, and computer program products for determining a location from non-line-of-sight (NLOS) signals are described. An RF receiver can receive signals of an RF transmitter (e.g., a GNSS satellite) reflected by one or more building surfaces. A processor embedded in or coupled to the RF receiver can reduce the effects of multipath interference caused by the reflections using data on reflective characteristics of buildings located close to the RF receiver. The data can include information on which surfaces of the buildings are visible to the RF receiver. The processor can then estimate, from the visible surfaces and known satellite locations, feasible signal paths for a signal from a satellite to the RF receiver. The processor can then correct a location estimation by taking into account the multipath effects of the signal traveling along the feasible signal paths.

Abstract: A detonator system is provided for use with explosives that utilizes two subsystems. A first subsystem functions as a non-explosives based detonator, which does not contain any explosives. The second subsystem is an initiating subsystem, which includes an initiating pellet. To set off an explosive event, the non-energetics based detonator is coupled to the initiating subsystem and the non-energetics based detonator is commanded to provide a suitable signal to the initiating subsystem that is sufficient to function the initiating pellet. Further, the initiating subsystem can be integrated directly into an associated explosive such as a booster that has been configured to receive the initiator subsystem without changing the hazard class of the booster.

Abstract: A navigation system includes a navigation radio and a sensor onboard a vehicle. The navigation radio receives and processes low earth orbit RF signals to derive range observables for a corresponding LEO satellite. A sensor is operable to generate at least one of vehicle speed data, acceleration data, angular rate data and rotational angle data under high vehicle dynamics. The navigation radio includes a navigation code operable to obtain a position, velocity and time solution (a “navigation solution”) based on the one or more range observables, ephemerides for the corresponding LEO satellite, a heading pseudomeasurement, a navigation radio altitude pseudomeasurement; one or more vehicle velocity pseudomeasurements orthogonal to the altitude pseudomeasurements; and the generated at least one of vehicle speed data, acceleration data, angular rate data and rotational angle data. The navigation radio uses the navigation solution to acquire a GPS signal during interference with a coarse acquisition GPS signal.

Abstract: The invention provides for novel cysteine protease inhibitors and compositions comprising novel cysteine protease derivatives. The invention further provides for methods for treatment of neurodegenerative diseases comprising administration novel cysteine protease inhibitors or compositions comprising novel cysteine protease inhibitors. In some embodiments, the cysteine protease inhibitors are calpain inhibitors.

Abstract: Disclosed is a composition comprising ascorbic acid or a derivative thereof, a silicone containing compound, and an essential oil, wherein at least 50% of the initial amount of the ascorbic acid in the composition remains stable when the composition is stored for at least 1 month at room temperature. The composition can be non-aqueous.

Abstract: Disclosed is a composition comprising ascorbic acid or a derivative thereof, a silicone containing compound, and an essential oil, wherein at least 50% of the initial amount of the ascorbic acid in the composition remains stable when the composition is stored for at least 1 month at room temperature. The composition can be non-aqueous.

Abstract: A navigation system includes a navigation radio and a sensor onboard a vehicle. The navigation radio receives and processes low earth orbit RF signals to derive range observables for a corresponding LEO satellite. A sensor is operable to generate at least one of vehicle speed data, acceleration data, angular rate data and rotational angle data under high vehicle dynamics. The navigation radio includes a navigation code operable to obtain a position, velocity and time solution (a “navigation solution”) based on the one or more range observables, ephemerides for the corresponding LEO satellite, a heading pseudomeasurement, a navigation radio altitude pseudomeasurement; one or more vehicle velocity pseudomeasurements orthogonal to the altitude pseudomeasurements; and the generated at least one of vehicle speed data, acceleration data, angular rate data and rotational angle data. The navigation radio uses the navigation solution to acquire a GPS signal during interference with a coarse acquisition GPS signal.

Abstract: A navigation system includes a navigation radio and a sensor onboard a vehicle. The navigation radio receives and processes low earth orbit RF signals to derive range observables for a corresponding LEO satellite. A sensor is operable to generate at least one of vehicle speed data, acceleration data, angular rate data and rotational angle data under high vehicle dynamics. The navigation radio includes a navigation code operable to obtain a position, velocity and time solution (a “navigation solution”) based on the one or more range observables, ephemerides for the corresponding LEO satellite, a heading pseudomeasurement, a navigation radio altitude pseudomeasurement; one or more vehicle velocity pseudomeasurements orthogonal to the altitude pseudomeasurements; and the generated at least one of vehicle speed data, acceleration data, angular rate data and rotational angle data. The navigation radio uses the navigation solution to acquire a GPS signal during interference with a coarse acquisition GPS signal.

Abstract: A detonator system is provided for use with explosives that utilizes two subsystems. A first subsystem functions as a non-explosives based detonator, which does not contain any explosives. The second subsystem is an initiating subsystem, which includes an initiating pellet. To set off an explosive event, the non-energetics based detonator is coupled to the initiating subsystem and the non-energetics based detonator is commanded to provide a suitable signal to the initiating subsystem that is sufficient to function the initiating pellet. Further, the initiating subsystem can be integrated directly into an associated explosive such as a booster that has been configured to receive the initiator subsystem without changing the hazard class of the booster.

Abstract: An interactive mixed reality simulator is provided that includes a virtual 3D model of internal or hidden features of an object; a physical model or object being interacted with; and a tracked instrument used to interact with the physical object. The tracked instrument can be used to simulate or visualize interactions with internal features of the physical object represented by the physical model. In certain embodiments, one or more of the internal features can be present in the physical model. In another embodiment, some internal features do not have a physical presence within the physical model.

Abstract: A navigation system includes a navigation radio and a sensor onboard a vehicle. The navigation radio receives and processes low earth orbit RF signals to derive range observables for a corresponding LEO satellite. A sensor is operable to generate at least one of vehicle speed data, acceleration data, angular rate data and rotational angle data under high vehicle dynamics. The navigation radio includes a navigation code operable to obtain a position, velocity and time solution (a “navigation solution”) based on the one or more range observables, ephemerides for the corresponding LEO satellite, a heading pseudomeasurement, a navigation radio altitude pseudomeasurement; one or more vehicle velocity pseudomeasurements orthogonal to the altitude pseudomeasurements; and the generated at least one of vehicle speed data, acceleration data, angular rate data and rotational angle data. The navigation radio uses the navigation solution to acquire a GPS signal during interference with a coarse acquisition GPS signal.

Abstract: A navigation system includes a navigation radio and sensor mountable to a pedal subject. The navigation radio processes RF signals to derive successive range observables for one or more overhead assets such as low-earth orbit (LEO) satellites. A sensor is operable to generate output useful in computing successive positional dead reckoning (PDR) data under pedal motion. The radio includes navigation code operable to obtain a navigation solution including an absolute position solution and one or more of a velocity solution, time solution, and attitude solution based on the successive range observables, ephemerides for the corresponding LEO satellite, and the generated successive PDR data. A PDR component including pedal motion constraints is corrected by occasional LEO satellite ranging data to generate a highly-accurate pedal navigation solution in environments where GPS fails, such as in buildings, shopping malls, dense forests, deep open-pit mines, urban canyons, or in jammed signal environments.

Abstract: Disclosed is a composition comprising ascorbic acid or a derivative thereof, a silicone containing compound, and an essential oil, wherein at least 50% of the initial amount of the ascorbic acid in the composition remains stable when the composition is stored for at least 1 month at room temperature. The composition can be non-aqueous.

Abstract: A sunless skin tanning emulsion is disclosed. The emulsion can be a water-in-silicon emulsion and can include a skin tanning agent and a silicon containing compound comprising the formula: wherein, R1, R2, R3, are independently CH3, [CH2]3—[OCH2CH2]w—OH, or [CH2]m-A. Also disclosed are methods of using the emulsions in sunless skin tanning applications.