Abstract: Nucleic acid molecules, compositions, recombinant AAV (rAAV) particles, kits, and methods are described herein for delivering a base editor (or “nucleobase editor”) to cells, e.g., via AAV vectors. In particular, the disclosure provides compositions, methods, and uses for delivery of adenine base editors and cytosine base editors in a single AAV vector (or genome). Further described herein are improved AAV vectors containing size-minimized regulatory components that enable, e.g., the packaging of base editors. Provided herein are methods and compositions for delivering base editor proteins to a cell or tissue in a single recombinant AAV (rAAV) vector. Contemplated herein are improved methods and compositions for delivering these base editors in vivo, in a single rAAV particle. Further provided herein are base editors and compositions and cells comprising these base editors.

Abstract: A system and method for well log vectorization are described that assist geologists or other technicians to rapidly and accurately vectorize well log curves that are visually evident in a raster well log image. The resulting digital well log curves are instrumental for qualitative interpretation and quantitative analysis of geologic information measured along well bores. The system and method simplifies and makes more efficient and accurate the process of vectorizing well log curves that are displayed in a digital raster log image.

Abstract: A system and method for well log vectorization are described that assist geologists or other technicians to rapidly and accurately vectorize well log curves that are visually evident in a raster well log image. The resulting digital well log curves are instrumental for qualitative interpretation and quantitative analysis of geologic information measured along well bores. The system and method simplifies and makes more efficient and accurate the process of vectorizing well log curves that are displayed in a digital raster log image.

Abstract: A system and method for well log vectorization are described that assist geologists or other technicians to rapidly and accurately vectorize well log curves that are visually evident in a raster well log image. The resulting digital well log curves are instrumental for qualitative interpretation and quantitative analysis of geologic information measured along well bores. The system and method simplifies and makes more efficient and accurate the process of vectorizing well log curves that are displayed in a digital raster log image.