Patents by Inventor Isabel Ayala

Isabel Ayala has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the specific isotopic labeling of methyl groups of Val, Leu and Ile
    Patent number: 10053396
    Abstract: A process for the specific isotopic labeling of an amino acid selected from Valine (Val), Leucine (Leu), and Isoleucine (Ile), in proteins and biomolecular assemblies by introducing, in a medium containing bacteria overexpressing a protein, an acetolactate derivative of Formula I of the application.
    Type: Grant
    Filed: June 13, 2017
    Date of Patent: August 21, 2018
    Assignees: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE JOSEPH FOURIER
    Inventors: Pierre Gans, Jerome Boisbouvier, Isabel Ayala, Olivier Hamelin
  • PROCESS FOR THE SPECIFIC ISOTOPIC LABELING OF METHYL GROUPS OF VAL, LEU AND ILE
    Publication number: 20170275216
    Abstract: A process for the specific isotopic labeling of an amino acid selected from Valine (Val), Leucine (Leu), and Isoleucine (Ile), in proteins and biomolecular assemblies by introducing, in a medium containing bacteria overexpressing a protein, an acetolactate derivative of Formula I of the application.
    Type: Application
    Filed: June 13, 2017
    Publication date: September 28, 2017
    Applicants: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNVERSITE JOSEPH FOURIER
    Inventors: Pierre GANS, Jerome BOISBOUVIER, Isabel AYALA, Olivier HAMELIN
  • Process for the specific isotopic labeling of methyl groups of Val, Leu and Ile
    Patent number: 9708228
    Abstract: The invention relates to a process for the specific isotopic labeling of Valine, Leucine and Isoleucine amino acids. The process of the invention uses a 2-alkyl-2-hydroxy-3-oxobutanoic acid in which the alkyl substituent in position 2 is ethyl or methyl. The invention can be used for the analysis of proteins, in particular by NMR.
    Type: Grant
    Filed: January 6, 2010
    Date of Patent: July 18, 2017
    Assignees: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE JOSEPH FOURIER
    Inventors: Pierre Gans, Jérôme Boisbouvier, Isabel Ayala, Olivier Hamelin
  • Wheat plants with immunity to wheat streak mosaic virus (WSMV)
    Patent number: 8536403
    Abstract: The present invention provides a transgenic wheat cell or wheat plant, the wheat cell or wheat plant comprising a chimeric DNA molecule which encodes a dsRNA molecule which is capable of inhibiting wheat streak mosaic virus (WSMV) replication, wherein the wheat cell or plant is immune to WSMV. The present invention also provides a chimeric DNA, the chimeric DNA comprising (i) a wheat expressible promoter; (ii) a region which encodes a dsRNA which is capable of inhibiting WSMV replication; and (iii) a transcription termination and polyadenylation signal.
    Type: Grant
    Filed: September 17, 2010
    Date of Patent: September 17, 2013
    Assignee: Commonwealth Scientific and Industrial Research Organisation
    Inventors: Muhammad Fahim, Philip John Larkin, Ligia Isabel Ayala-Navarrete, Anthony Alan Millar
  • PROCESS FOR THE SPECIFIC ISOTOPIC LABELING OF METHYL GROUPS OF VAL, LEU AND ILE
    Publication number: 20130122598
    Abstract: The invention relates to a process for the specific isotopic labeling of Valine, Leucine and Isoleucine amino acids. The process of the invention uses a 2-alkyl-2-hydroxy-3-oxobutanoic acid in which the alkyl substituent in position 2 is ethyl or methyl. The invention can be used for the analysis of proteins, in particular by NMR.
    Type: Application
    Filed: January 6, 2010
    Publication date: May 16, 2013
    Applicants: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES, UNIVERSITE JOSEPH FOURIER, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Pierre Gans, Jerome Boisbouvier, Isabel Ayala, Olivier Hamelin
  • Wheat plants with immunity to wheat streak mosaic virus (WSMV)
    Publication number: 20110154534
    Abstract: The present invention provides a transgenic wheat cell or wheat plant, the wheat cell or wheat plant comprising a chimeric DNA molecule which encodes a dsRNA molecule which is capable of inhibiting wheat streak mosaic virus (WSMV) replication, wherein the wheat cell or plant is immune to WSMV. The present invention also provides a chimeric DNA, the chimeric DNA comprising (i) a wheat expressible promoter; (ii) a region which encodes a dsRNA which is capable of inhibiting WSMV replication; and (iii) a transcription termination and polyadenylation signal.
    Type: Application
    Filed: September 17, 2010
    Publication date: June 23, 2011
    Inventors: Muhammad Fahim, Philip John Larkin, Ligia Isabel Ayala-Navarrete, Anthony Alan Millar