Patents by Inventor Isabel D. C. Markl

Isabel D. C. Markl has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methylation altered DNA sequences as markers associated with human cancer
    Patent number: 7662549
    Abstract: There is disclosed 103 novel methylation-altered DNA sequences (“marker sequences”) that have distinct methylation patterns in cancer, compared to normal tissue. In many instances, these marker sequences represent novel sequences not found in the GenBank data base, and none of these marker sequences have previously been characterized with respect to their methylation pattern in human cancers including, but not limited to those of bladder and prostate. These 103 sequences have utility as diagnostic, prognostic and therapeutic markers in the treatment of human cancer, and as reagents in kits for detecting methylated CpG-containing nucleic acids.
    Type: Grant
    Filed: October 27, 2000
    Date of Patent: February 16, 2010
    Assignee: The University of Southern California
    Inventors: Isabel D. C. Markl, Peter A. Jones, Yoshitaka Tomigahara, Gangning Liang, Hualin Fu, Jonathan Cheng