Patents by Inventor Isabel Goncalves

Isabel Goncalves has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220390457
    Abstract: The invention relates to the field of diagnostic immunology. Provided are means and methods for multiparameter cytometry-based leukocyte subsetting, which is advantageously used for the monitoring of the immune status of a subject, and/or for monitoring the effects of an immune modulatory treatment. Provided among others is a reagent composition comprising antibodies conjugated to a detectable label, the conjugated antibodies being directed against the following combination of markers: CD141, HLA-DR, CD16, CD33, CD300e, CD303 and CD14, wherein the antibodies directed against CD300e and CD303 may be conjugated to the same label.
    Type: Application
    Filed: November 5, 2020
    Publication date: December 8, 2022
    Inventors: Jacobus Johannes Maria Van Dongen, José Alberto Orfao De Matos Correia E Vale, Cristina Isabel Gonçalves Grunho Teodósio, Martín Pérez Y Andrés, Julia Maria Almeida Parra, Wouter Bernard Louis Van Den Bossche, Vitor Dessanti Botafogo Goncalves, Magdalena Agnieszka Berkowska, Kyra Van Der Pan, Elena Blanco Álvarez, Annieck Margo Diks, Daniela Pinto Damasceno, Alejandro Hernández Delgado
  • Patent number: 10788481
    Abstract: The invention relates to methods to evaluate in one single assay the biocompatibility of materials based on the simultaneous determination of the phagocytosis, cell activation and cell death produced by said materials, preferably, in peripheral blood or other human cells and proximal fluids. The invention also relates to a kit to perform the method of the invention.
    Type: Grant
    Filed: July 5, 2017
    Date of Patent: September 29, 2020
    Assignees: UNIVERSIDAD DE SALAMANCA, IMMUNOSTEP S.L.
    Inventors: Manuel Fuentes Garcia, Paula Diez Garcia, Cristina Isabel Gonçalves Grunho Tedosio, Alberto Orfao de Matos, Ricardo Jara Acevedo
  • Patent number: 10196624
    Abstract: The invention relates to aspartic proteases, and particularly to aspartic proteases for plants. Disclosed are modified plant aspartic proteases, and methods for their manufacture, and uses thereof. Particularly contemplated are the uses of aspartic proteases in clotting milk.
    Type: Grant
    Filed: March 19, 2014
    Date of Patent: February 5, 2019
    Assignee: Biocant—Associacao De Transferencia De Tecnologia
    Inventors: Carla Sofia Gomes Malaquias de Almeida, Isaura Isabel Gonçalves Simões, Carlos José Fialho Costa Faro
  • Patent number: 9890372
    Abstract: Methods and composition, thereof, relate to aspartic proteases, and particularly to aspartic proteases for plants. Disclosed are modified plant aspartic proteases, and methods for their manufacture, and uses thereof. Particularly contemplated are the uses of aspartic proteases in inducing skin desquamation.
    Type: Grant
    Filed: March 19, 2014
    Date of Patent: February 13, 2018
    Assignee: BIOCANT—ASSOCIAÇÃO DE TRANSFERÊNCIA DE TECHNOLOGIA
    Inventors: Carla Sofia Gomes Malaquias de Almeida, Isaura Isabel Gonçalves Simões, Carlos José Fialho Costa Faro
  • Publication number: 20180011083
    Abstract: The invention relates to methods to evaluate in one single assay the biocompatibility of materials based on the simultaneous determination of the phagocytosis, cell activation and cell death produced by said materials, preferably, in peripheral blood or other human cells and proximal fluids. The invention also relates to a kit to perform the method of the invention.
    Type: Application
    Filed: July 5, 2017
    Publication date: January 11, 2018
    Inventors: Manuel FUENTES GARCIA, Paula DIEZ GARCIA, Cristina Isabel Gonçalves GRUNHO TEODOSIO, Alberto ORFAO DE MATOS, Ricardo JARA ACEVEDO
  • Publication number: 20170157168
    Abstract: The invention relates to the use of carbon monoxide (CO) to inhibit the gastrointestinal side effects caused by non-steroidal anti-inflammatory drugs (NSAIDs) and/or alcohol.
    Type: Application
    Filed: July 25, 2016
    Publication date: June 8, 2017
    Inventors: Sandra Sofia Pereira Rodrigues, Joaõ D. Seixas, Bruno Guerreiro, Nuno Miguel Penacho Pereira, Carlos C. Romão, Werner E. Haas, Isabel Goncalves
  • Publication number: 20160186160
    Abstract: The invention relates to aspartic proteases, and particularly to aspartic proteases for plants. Disclosed are modified plant aspartic proteases, and methods for their manufacture, and uses thereof. Particularly contemplated are the uses of aspartic proteases in inducing skin desquamation.
    Type: Application
    Filed: March 19, 2014
    Publication date: June 30, 2016
    Applicant: Biocant-Associaçäo de Transferência de Tecnologia
    Inventors: Carla Sofia Gomes Malaquias de ALMEIDA, Isaura Isabel Gonçalves SIMÖES, Carlos José Fialho Costa FARO
  • Publication number: 20160083711
    Abstract: The invention relates to aspartic proteases, and particularly to aspartic proteases for plants. Disclosed are modified plant aspartic proteases, and methods for their manufacture, and uses thereof. Particularly contemplated are the uses of aspartic proteases in clotting milk.
    Type: Application
    Filed: March 19, 2014
    Publication date: March 24, 2016
    Inventors: Carla Sofia Gomes Malaquias de Almeida, Isaura Isabel Gonçalves Simões, Carlos José Fialho Costa Faro
  • Patent number: 9023402
    Abstract: Several classes of in vivo carbon monoxide-releasing compounds are useful for the treatment and/or prevention of diseases, such as chronic inflammatory, e.g., rheumatoid arthritis, and of diseases with a strong inflammatory component, such as atherosclerosis, stroke, coronary disease, and Alzheimers disease. The in vivo carbon monoxide-releasing compounds can be attached to known drug vectors and/or known anti-inflammatory drugs, such as aspirin.
    Type: Grant
    Filed: April 1, 2011
    Date of Patent: May 5, 2015
    Assignee: ALFAMA—Investigação e Desenvolvimento de Produtos Farmacêuticos, Lda.
    Inventors: Werner E. Haas, Carlos C. Romao, Beatriz Royo, Ana Cristina Fernandes, Isabel Goncalves
  • Publication number: 20140212514
    Abstract: The invention relates to the use of carbon monoxide (CO) to inhibit the gastrointestinal side effects caused by non-steroidal anti-inflammatory drugs (NSAIDs) and/or alcohol.
    Type: Application
    Filed: October 11, 2013
    Publication date: July 31, 2014
    Applicant: ALFAMA - Investigacao e Desenvolvimento de Produtos Farmaceuticos, Lda.
    Inventors: Sandra Sofia Pereira Rodrigues, Joaõ D. Seixas, Bruno Guerreiro, Nuno Miguel Penacho Pereira, Carlos C. Romão, Werner E. Haas, Isabel Goncalves
  • Publication number: 20110237546
    Abstract: Several classes of in vivo carbon monoxide-releasing compounds are useful for the treatment and/or prevention of diseases, such as chronic inflammatory, e.g., rheumatoid arthritis, and of diseases with a strong inflammatory component, such as atherosclerosis, stroke, coronary disease, and Alzheimers disease. The in vivo carbon monoxide-releasing compounds can be attached to known drug vectors and/or known anti-inflammatory drugs, such as aspirin.
    Type: Application
    Filed: April 1, 2011
    Publication date: September 29, 2011
    Inventors: Werner Haas, Carlos Romao, Beatriz Royo, Ana C. Fernandes, Isabel Goncalves
  • Patent number: 7964220
    Abstract: Several classes of in vivo carbon monoxide-releasing compounds are useful for the treatment and/or prevention of diseases, such as chronic inflammatory, e.g., rheumatoid arthritis, and of diseases with a strong inflammatory component, such as atherosclerosis, stroke, coronary disease, and Alzheimers disease. The in vivo carbon monoxide-releasing compounds can be attached to known drug vectors and/or known anti-inflammatory drugs, such as aspirin.
    Type: Grant
    Filed: June 14, 2006
    Date of Patent: June 21, 2011
    Assignee: ALFAMA—Investigação e Desenvolvimento de Produtos Farmacêuticos, Lda.
    Inventors: Werner E. Haas, Carlos C. Romao, Beatriz Royo, Ana Cristina Fernandes, Isabel Goncalves
  • Publication number: 20070207217
    Abstract: The present invention relates to molybdenum carbonyl complexes useful for inhibiting tumor necrosis factor (TNF) production and for treating inflammatory diseases.
    Type: Application
    Filed: December 20, 2006
    Publication date: September 6, 2007
    Applicant: Alfama - Investigacao e Desenvolvimento De Productos Farmaceuticos Lda
    Inventors: Werner Haas, Carlos Romao, Sandra Rodrigues, Joao Seixas, Ana Pina, Beatriz Royo, Ana Fernandes, Isabel Goncalves
  • Publication number: 20060233890
    Abstract: Several classes of in vivo carbon monoxide-releasing compounds are useful for the treatment and/or prevention of diseases, such as chronic inflammatory, e.g., rheumatoid arthritis, and of diseases with a strong inflammatory component, such as atherosclerosis, stroke, coronary disease, and Alzheimers disease. The in vivo carbon monoxide-releasing compounds can be attached to known drug vectors and/or known anti-inflammatory drugs, such as aspirin.
    Type: Application
    Filed: June 14, 2006
    Publication date: October 19, 2006
    Applicant: Alfama - Investigacao e Desenvolvimento de Produtos Farmaceuticos Lda
    Inventors: Werner Haas, Carlos Romao, Beatriz Royo, Ana Fernandes, Isabel Goncalves
  • Publication number: 20060148900
    Abstract: Several classes of in vivo carbon monoxide-releasing compounds are useful for the treatment and/or prevention of diseases, such as chronic inflammatory, e.g., rheumatoid arthritis, and of diseases with a strong inflammatory component, such as atherosclerosis, stroke, coronary disease, and Alzheimers disease. The in vivo carbon monoxide-releasing compounds can be attached to known drug vectors and/or known anti-inflammatory drugs, such as aspirin.
    Type: Application
    Filed: November 29, 2005
    Publication date: July 6, 2006
    Applicant: Alfama - Investigacao e Desenvolvimento de Produtos Farmaceuticos Lda
    Inventors: Werner Haas, Carlos Romao, Beatriz Royo, Ana Fernandes, Isabel Goncalves
  • Patent number: 7011854
    Abstract: Several classes of in vivo carbon monoxide-releasing compounds are useful for the treatment and/or prevention of diseases, such as chronic inflammatory, e.g., rheumatoid arthritis, and of diseases with a strong inflammatory component, such as atherosclerosis, stroke, coronary disease, and Alzheimers disease. The in vivo carbon monoxide-releasing compounds can be attached to known drug vectors and/or known anti-inflammatory drugs, such as aspirin.
    Type: Grant
    Filed: February 3, 2003
    Date of Patent: March 14, 2006
    Assignee: Alfama-Investigacao e Desenvolvimento de Produtos Farmaceuticos Lda
    Inventors: Werner Haas, Carlos Romao, Beatriz Roya, Ana Cristina Fernandes, Isabel Goncalves
  • Patent number: 6807032
    Abstract: A ferromagnetic shield material having a minimized anisotropic magneto-resistance effect permits the use of a combined shield/electrical lead for magneto-resistive read elements. The shields/electrical leads may therefore be placed closer together, maximizing the recording density that may be read by a magnetic recording head using a read element having such shields/leads.
    Type: Grant
    Filed: February 2, 2001
    Date of Patent: October 19, 2004
    Assignee: Seagate Technology LLC
    Inventors: Michael Allen Seigler, Isabel Goncalves Trindade, Petrus Antonius Van der Heijden, Michael Kevin Minor, Mark William Covington, Rene' Johannes Marinus van de Veerdonk, Sharat Batra, Robert Earl Rottmayer
  • Publication number: 20040067261
    Abstract: Several classes of in vivo carbon monoxide-releasing compounds are useful for the treatment and/or prevention of diseases, such as chronic inflammatory, e.g., rheumatoid arthritis, and of diseases with a strong inflammatory component, such as atherosclerosis, stroke, coronary disease, and Alzheimers disease. The in vivo carbon monoxide-releasing compounds can be attached to known drug vectors and/or known anti-inflammatory drugs, such as aspirin.
    Type: Application
    Filed: February 3, 2003
    Publication date: April 8, 2004
    Inventors: Werner Haas, Carlos Romao, Beatriz Roya, Ana Cristina Fernandes, Isabel Goncalves
  • Patent number: 6621664
    Abstract: An integrated read/write perpendicular recording head facilitates the use of magnetic storage media having a high magnetic recording density and high data rates. The use of a perpendicular write portion provides adequate space between the main and opposing poles for a read element and associated electrical contacts therebetween. The use of a differential dual spin valve as a read element eliminates the need for magnetic shielding of the read element. Such a structure permits the read element and main write pole to be close together, thereby minimizing seek time, and permitting rapid transition from read to write operations, and vice versa.
    Type: Grant
    Filed: February 28, 2001
    Date of Patent: September 16, 2003
    Assignee: Seagate Technology LLC
    Inventors: Isabel Goncalves Trindade, Gregory John Parker, Sharat Batra, Robert Rottmayer