Abstract: The present invention relates to novel injectable presentations, kits or syringes comprising a composition with sustained or controlled release of lanreotide or one of the salts thereof. The compositions of lanreotide or one of the salts thereof are packaged in a syringe having a diameter greater than 3.00 mm and provided with a needle having an outer diameter no greater than 1.00 mm.

Abstract: An aerosol-generating system is provided, including an aerosol-generating device and an aerosol-forming substrate, the aerosol-generating device including: a holding and exposing space configured to receive an aerosol-forming substrate; and an electromagnetic field generator configured to generate a radio frequency (RF) electromagnetic field in the holding and exposing space, the aerosol-forming substrate being configured to be received in the holding and exposing space, the aerosol-forming substrate including or contained within a liquid-filled capsule or a gel-filled capsule, the liquid-filled capsule or gel-filled capsule being configured to rupture when the liquid or the gel is dielectrically heated by the RF electromagnetic field in the holding and exposing space. A method for generating an aerosol from an aerosol-forming substrate is also provided. A capsule for insertion into a holding and exposing space of an aerosol-generating device is also provided.

Abstract: An aerosol-generating device for heating an aerosol-forming substrate to generate an aerosol is provided, the aerosol-generating device including: a substrate cavity configured to receive an aerosol-forming substrate; and an electromagnetic field generator including a solid state radio frequency (RF) transistor and being configured to generate a RF electromagnetic field in the substrate cavity. A method for generating an aerosol from an aerosol-forming substrate is also provided. An aerosol-generating article is also provided.

Abstract: The present invention relates to an aerosol-generating arrangement for generating an aerosol from an aerosol-forming liquid. The aerosol-generating arrangement comprises a liquid reservoir for storing aerosol-forming liquid and a capillary liquid conveyer for conveying aerosol-forming liquid from the liquid reservoir via a reservoir orifice to an evaporation section of the liquid conveyer outside the reservoir. The aerosol-generating arrangement further comprises an air duct for passing an airflow past the evaporation section. The liquid reservoir is a volume compensating liquid reservoir which is configured to counteract capillary imbibition of the capillary liquid conveyer. The air duct comprises an ejector portion including an air jet generating member and an expansion zone downstream the air jet generating member.

Abstract: An aerosol-generating system is provided, including: an aerosol-forming substrate; a first electrode and a second electrode spaced apart from the first electrode; an aerosol-generating device including a power supply, and a controller configured to connect to the first electrode and the second electrode; and a capacitor including the first electrode, the second electrode, and at least a portion of the aerosol-forming substrate, the controller being configured to supply an alternating voltage to the first electrode and the second electrode for dielectrically heating the aerosol-forming substrate, measure or determine an electrical property between the first electrode and the second electrode, and control heating of the aerosol-forming substrate based on the measured or determined electrical property.

Abstract: A cartridge for a radiation heated aerosol-generating device. A wall of the cartridge defines a cavity. An aerosol-forming substrate is housed within the cavity. The outer surface of the wall of the cartridge comprises a high emissivity material. The invention further relates to an aerosol-generating device for use with the cartridge, and to an aerosol-generating device or a shisha device comprising the aerosol-generating device, to a system comprising both the aerosol-generating device and the cartridge, and to a method for forming an aerosol in an aerosol-generating device.

Abstract: A device (100) for heating an aerosol-forming substrate includes a heater (160), a receptacle inlet (143) and outlet (147), and an air inlet channel (170). The heater includes a heating element, an internal surface, and an external surface. The internal surface defines at least a portion of a receptacle (140) configured to receive the aerosol-forming substrate or a cartridge comprising the aerosol-forming substrate. The receptacle inlet is in communication with, and upstream of, the receptacle. The receptacle outlet is in communication with, and downstream of, the receptacle. The air inlet channel is in communication with an ambient environment and the receptacle inlet. The air inlet channel defines a tortuous path between the ambient environment and the receptacle inlet. The air inlet channel is positioned relative to the heater to cause air in the tortuous path to be heated by the heater.

Abstract: A shisha cartridge comprises a body defining a cavity and an internal cavity surface. The cartridge comprises an aerosol-forming substrate disposed in the cavity and comprises a layer of gel disposed in the cavity adjacent the internal cavity surface. As the cartridge is heated, the gel may improve aerosol formation.

Abstract: An aerosol-generating device is provided, including: a heating chamber configured to receive an aerosol-forming substrate; and a heater assembly configured to heat the aerosol-forming substrate, the heater assembly including a photonic device configured to generate a beam of electromagnetic radiation, the aerosol-generating device being configured to heat the aerosol-forming substrate by directing the beam of electromagnetic radiation onto the aerosol-forming substrate, and the heating chamber being arranged between the photonic device and a mouth-end of the aerosol-generating device with respect to a longitudinal axis of the aerosol-generating device. An aerosol-generating system including the aerosol-generating device and an aerosol-generating article is also provided.

Abstract: A dielectrically heatable aerosol-generating system is provided, including: an aerosol-forming substrate; a plurality of pairs of electrodes, each pair of electrodes including a first electrode spaced apart from a second electrode; and an aerosol-generating device including a controller configured to connect to each pair of electrodes, in which each pair of electrodes forms a capacitor with a portion of the aerosol-forming substrate, and in which the controller is further configured to supply an alternating voltage to the plurality of pairs of electrodes for dielectrically heating the aerosol-forming substrate. An aerosol-generating article for a dielectrically heated aerosol-generating system is also provided.

Abstract: A dielectrically heatable aerosol-generating system is provided, including: an aerosol-forming substrate; a first electrode and a second electrode; and an aerosol-generating device including a controller configured to connect to the first electrode and the second electrode, in which the first electrode and the second electrode form a capacitor with a portion of the aerosol-forming substrate, in which the controller is further configured to supply an alternating voltage to the first electrode and the second electrode for dielectrically heating the aerosol-forming substrate, and in which the first electrode and the second electrode are configured to be spaced apart by a separation distance of between about 4 millimeters and about 9 millimeters. An aerosol-generating article for a dielectrically heated aerosol-generating system is also provided.

Abstract: An aerosol-generating system is provided, including: an aerosol-forming substrate; a first electrode and a second electrode spaced apart from the first electrode; an aerosol-generating device including a power supply, and a controller configured to connect to the first electrode and the second electrode; and a capacitor including the first electrode, the second electrode, and at least a portion of the aerosol-forming substrate, the controller being configured to supply an alternating voltage to the first electrode and the second electrode for dielectrically heating the aerosol-forming substrate, measure or determine an electrical property between the first electrode and the second electrode, and control heating of the aerosol-forming substrate based on the measured or determined electrical property.

Abstract: A shisha device comprises a cooling element (13) disposed along an airflow channel to cool an aerosol. The cooling element unit utilizes active cooling and may additionally utilize passive cooling. The cooling element may comprise a conduit (21) comprising a thermally conductive material. The cooling element may be integrally formed with an accelerating element (14) disposed along the airflow channel. Cooling may occur before or during acceleration of the aerosol by the accelerating element. The cooling may contribute to the condensation in the aerosol.

Abstract: An aerosol-generating device is provided for heating an aerosol-forming substrate to generate an aerosol, the aerosol-generating device including: an electromagnetic field generator configured to generate radio-frequency (RF) electromagnetic radiation having a predetermined frequency composition; a resonant chamber including a peripheral wall configured to be substantially opaque to RF electromagnetic radiation within the resonant chamber; and a filling arranged within an interior of the resonant chamber so as to circumscribe a substrate cavity defined within the resonant chamber, the substrate cavity being configured to receive the aerosol-forming substrate, the electromagnetic field generator being coupled to the resonant chamber so as to convey the RF electromagnetic radiation generated by the electromagnetic field generator to the resonant chamber, and the filling having a relative permittivity of greater than one.

Abstract: The present invention relates to novel injectable presentations, kits or syringes comprising a composition with sustained or controlled release of lanreotide or one of the salts thereof. The compositions of lanreotide or one of the salts thereof are packaged in a syringe having a diameter greater than 3.00 mm and provided with a needle having an outer diameter no greater than 1.00 mm.

Abstract: Chimeric antigen comprising multimeric aggregates of the extracellular domain of the programmed death ligand 1 (PD-L1) with a reduced binding capacity to the PD-1 and CD80 receptors as compared to the native PD-L1 molecule. The invention further discloses pharmaceutical compositions including said chimeric antigen and at least a pharmaceutically acceptable vaccine adjuvant. The chimeric antigen is used for the manufacturing of a drug to treat cancer or its metastases. The invention also discloses a method of treating cancer or its metastases in a subject in need thereof, characterized by the administration of a therapeutically effective amount of the pharmaceutical composition comprising the chimeric antigen described herein.

Abstract: A shisha device (10) comprises an aerosol-generating element (11) for receiving an aerosol-forming substrate (12). The shisha device also comprises a vessel (17) spaced from the aerosol-generating element and defining an interior for housing a volume of liquid. The vessel comprises a head space outlet (15). The shisha device also comprises an aerosol conduit (21) positioned between the aerosol-generating element and the interior of the vessel. The aerosol conduit comprises a proximal end portion defining a proximal opening (24) positioned to receive airflow from the aerosol-generating element, a distal end portion defining a distal opening (26) positioned in the interior of the vessel, and a ventilation opening (30) positioned between the proximal and distal end portions. A ratio between the total aperture area of the ventilation opening and a transverse cross-sectional area of the aerosol conduit positioned proximate to the ventilation opening is at most 1:1000.

Abstract: The present invention relates to novel injectable presentations, kits or syringes comprising a composition with sustained or controlled release of lanreotide or one of the salts thereof. The compositions of lanreotide or one of the salts thereof are packaged in a syringe having a diameter greater than 3.00 mm and provided with a needle having an outer diameter no greater than 1.00 mm.

Abstract: An assembly having an aircraft door and auxiliary equipment. The aircraft door and the auxiliary equipment are connected by a flexible deformable bellows having creases. The door comprises a passing through hole and a support joinable to the first end of the bellows. The auxiliary equipment comprises a support joinable to the second end of the bellows and a projecting part. The projecting part is configured to have elevation movement and/or azimuth movement, and the projecting part crosses the interior of the bellows and the hole of the door and protrudes out of the door. At both ends of the bellows a clamp joins and tightens each end of the bellows with the corresponding support. There is a fixed joint between the first end of the bellows and the door and a movable joint between the second end of the bellows and the auxiliary equipment.

Abstract: A shisha system comprising an aerosol-generating article (90) and a shisha device (50). The aerosol-generating article (90) comprises an aerosol-forming substrate (92). The shisha system further comprises a first electrode (15) and a second electrode (16). The shisha device (50) comprises a liquid cavity (54) configured to contain a volume of liquid, the liquid cavity (54) having a head space outlet (60); an article cavity (14) configured to receive an aerosol-forming substrate (92), the article cavity (14) being in fluid communication with the liquid cavity (54). The shisha device further comprises an oscillation circuit (10) configured for connection to the first electrode (15) and the second electrode (16).