Patents by Inventor Isabel Llorente

Isabel Llorente has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cell-based assays employing voltage and calcium dyes
    Patent number: 7604959
    Abstract: Disclosed are novel compositions and methods employing cyclic nucleotide-gated channels and fluorescence dyes and other indicators in detecting changes of intracellular cAMP levels, for instance in response to the stimulation of G-protein-coupled receptors. CNG mutants comprising one or more pore mutations that enhance sensitivity to cAMP and decrease divalent cation-mediated blockage are used in a variety of assays, including detection of the G-protein-coupled receptor activity. Also disclosed are novel dye quencher formulations that are particularly suited for cell-based assays of protein interactions.
    Type: Grant
    Filed: April 12, 2007
    Date of Patent: October 20, 2009
    Assignee: Atto BioScience Inc.
    Inventors: Yong Yao, Liang Cao, Jianming Lu, Isabel Llorente
  • Novel cell-based assays employing voltage and calcium dyes
    Publication number: 20080166803
    Abstract: Disclosed are novel compositions and methods employing cyclic nucleotide-gated channels and fluorescence dyes and other indicators in detecting changes of intracellular cAMP levels, for instance in response to the stimulation of G-protein-coupled receptors. CNG mutants comprising one or more pore mutations that enhance sensitivity to cAMP and decrease divalent cation-mediated blockage are used in a variety of assays, including detection of the G-protein-coupled receptor activity. Also disclosed are novel dye quencher formulations that are particularly suited for cell-based assays of protein interactions.
    Type: Application
    Filed: April 12, 2007
    Publication date: July 10, 2008
    Inventors: Yong Yao, Liang Cao, Jianming Lu, Isabel Llorente
  • Cell-based assays employing voltage and calcium dyes
    Patent number: 7238213
    Abstract: Disclosed are novel compositions and methods employing cyclic nucleotide-gated channels and fluorescence dyes and other indicators in detecting changes of intracellular cAMP levels, for instance in response to the stimulation of G-protein-coupled receptors. CNG mutants comprising one or more pore mutations that enhance sensitivity to cAMP and decrease divalent cation-mediated blockage are used in a variety of assays, including detection of the G-protein-coupled receptor activity. Also disclosed are novel dye quencher formulations that are particularly suited for cell-based assays of protein interactions.
    Type: Grant
    Filed: November 1, 2004
    Date of Patent: July 3, 2007
    Assignee: Atto Bioscience
    Inventors: Yong Yao, Liang Cao, Jianming Lu, Isabel Llorente
  • Novel cell-based assays employing voltage and calcium dyes
    Publication number: 20050221426
    Abstract: Disclosed are novel compositions and methods employing cyclic nucleotide-gated channels and fluorescence dyes and other indicators in detecting changes of intracellular cAMP levels, for instance in response to the stimulation of G-protein-coupled receptors. CNG mutants comprising one or more pore mutations that enhance sensitivity to cAMP and decrease divalent cation-mediated blockage are used in a variety of assays, including detection of the G-protein-coupled receptor activity. Also disclosed are novel dye quencher formulations that are particularly suited for cell-based assays of protein interactions.
    Type: Application
    Filed: November 1, 2004
    Publication date: October 6, 2005
    Inventors: Yong Yao, Liang Cao, Jianming Lu, Isabel Llorente