Patents by Inventor Isabella Caniggia

Isabella Caniggia has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antibodies against human HIF-1?
    Patent number: 8889132
    Abstract: The invention relates to reagents and methods for detecting, diagnosing and screening for conditions associated with hydroxylated hypoxia inducible factor 1-? (HIF-1?). The invention also relates to novel monoclonal antibodies specific for hydroxylated HIF-1?, or binding fragments thereof, and related nucleic acids, vectors, cells and compositions, as well as methods of using the antibodies in methods of the invention.
    Type: Grant
    Filed: June 30, 2011
    Date of Patent: November 18, 2014
    Assignee: Mount Sinai Hospital
    Inventors: Isabella Caniggia, Martin Post
  • Polynucleotides and Polypeptides Associated with Trophoblast Cell Death, Differentiation, Invasion and/or Cell Fusion and Turnover
    Publication number: 20140038908
    Abstract: The invention relates to polypeptides and polynucleotides associated with trophoblast cell death, differentiation, invasion, and/or cell fusion and turnover, and uses of same in the prevention, diagnosis and treatment of conditions requiring regulation of trophoblast cell death, differentiation, invasion, and/or cell fusion and turnover. In particular aspects, diagnostic methods are disclosed for evaluating conditions such as preeclampsia utilizing matador polypeptides and polynucleotides encoding same.
    Type: Application
    Filed: February 28, 2013
    Publication date: February 6, 2014
    Applicant: MT. SINAI HOSPITAL
    Inventors: Isabella Caniggia, Martin Post, Nima Soleymanlou, Andrea Jurisicova
  • REAGENTS AND METHODS FOR DIAGNOSING CONDITIONS ASSOCIATED WITH HYDROXYLATED HIF 1-ALPHA
    Publication number: 20130280736
    Abstract: The invention relates to reagents and methods for detecting, diagnosing and screening for conditions associated with hydroxylated hypoxia inducible factor 1-? (HIF-1?). The invention also relates to novel monoclonal antibodies specific for hydroxylated HIF-1?, or binding fragments thereof, and related nucleic acids, vectors, cells and compositions, as well as methods of using the antibodies in methods of the invention.
    Type: Application
    Filed: June 30, 2011
    Publication date: October 24, 2013
    Inventors: Isabella Caniggia, Martin Post
  • METHODS TO DIAGNOSE A REQUIRED REGULATION OF TROPHOBLAST INVASION
    Publication number: 20120064087
    Abstract: Methods are provided for the diagnosis and treatment of patients with increased risk of preeclampsia. The methods involve measuring levels of TGF-?3, receptors of cytokines of the TGf? family, or HIF-1?.
    Type: Application
    Filed: July 14, 2011
    Publication date: March 15, 2012
    Applicant: Mount Sinai Hospital
    Inventors: Isabella Caniggia, Martin Post, Stephen Lye
  • Method for diagnosing an increased risk of preeclampsia by measuring the level of HIF-?
    Patent number: 8007769
    Abstract: Methods are provided for the diagnosis and treatment of patients with increased risk of preeclampsia. The methods involve measuring levels of TGF-?3, receptors of cytokines of the TG? family, or HIF-1?.
    Type: Grant
    Filed: May 21, 2010
    Date of Patent: August 30, 2011
    Assignee: Mount Sinai Hospital
    Inventors: Isabella Caniggia, Martin Post, Stephen Lye
  • METHODS TO DIAGNOSE A REQUIRED REGULATION OF TROPHOBLAST INVASION
    Publication number: 20100291708
    Abstract: Methods are provided for the diagnosis and treatment of patients with increased risk of preeclampsia. The methods involve measuring levels of TGF-?3, receptors of cytokines of the TG? family, or HIF-1?.
    Type: Application
    Filed: May 21, 2010
    Publication date: November 18, 2010
    Applicant: Mount Sinai Hospital
    Inventors: Isabella Caniggia, Martin Post, Stephen Lye
  • Methods for early diagnosing of an increased risk of preeclampsia
    Patent number: 7754495
    Abstract: Methods are provided for the diagnosis and treatment of patients with increased risk of preeclampsia. The methods involve measuring levels of TGF-?3, receptors of cytokines of the TG? family, or HIF-1?.
    Type: Grant
    Filed: October 16, 2008
    Date of Patent: July 13, 2010
    Assignee: Mount Sinai Hospital
    Inventors: Isabella Caniggia, Martin Post, Stephen Lye
  • DIAGNOSTIC COMPOSITIONS AND TREATMENT METHODS FOR CONDITIONS INVOLVING TROPHOBLAST CELL DEATH, DIFFERENTIATION, INVASION AND/OR CELL FUSION AND TURNOVER
    Publication number: 20090246773
    Abstract: The invention provides a method for diagnosing in a subject a condition requiring modulation of or involving trophoblast cell death, differentiation, invasion, and/or cell fusion and turnover, comprising detecting HIF I? and the factors which modulate or are modulated by this protein, specifically TGF?3, sFLT, VEGF, SMAD2, 3 and 7, MtdP, MtdL, MclI 1, MclIc, VHL, SiahI, Siah2, ENG, and PHD. The invention also provides a method for diagnosing or distinguishing in a subject a specific condition requiring modulation of or involving trophoblast cell death, differentiation, invasion, and/or cell fusion and turnover, in particular early onset severe preeclampsia (EPE), late onset preeclampsia (LPE) and mtre-uterme growth restriction (IUGR) comprising detecting HLF I? and the factors which modulate or are modulated by this protein as defined above.
    Type: Application
    Filed: March 9, 2007
    Publication date: October 1, 2009
    Applicant: Mount Sinai Hospital
    Inventors: Isabella Caniggia, Alessandro Rolfo, Martin Post
  • Polynucleotides and polypeptides associated with trophoblast cell death, differentiation, invasion, and/or cell fusion and turnover
    Publication number: 20090239793
    Abstract: The invention relates to polypeptides and polynucleotides associated with trophoblast cell death, differentiation, invasion, and/or cell fusion and turnover, and uses of same in the prevention, diagnosis and treatment of conditions requiring regulation of trophoblast cell death, differentiation, invasion, and/or cell fusion and turnover. In particular aspects, diagnostic methods are disclosed for evaluating conditions such as preeclampsia utilizing matador polypeptides and polynucleotides encoding same.
    Type: Application
    Filed: September 23, 2005
    Publication date: September 24, 2009
    Inventors: Isabella Caniggia, Martin Post, Nima Soleymanlou, Andrea Jurisicova
  • METHODS TO DIAGNOSE A REQUIRED REGULATION OF TROPHOBLAST INVASION
    Publication number: 20090098146
    Abstract: Methods are provided for the diagnosis and treatment of patients with increased risk of preeclampsia. The methods involve measuring levels of TGF-?3, receptors of cytokines of the TG? family, or HIF-1?.
    Type: Application
    Filed: October 16, 2008
    Publication date: April 16, 2009
    Applicant: Mount Sinai Hospital
    Inventors: Isabella Caniggia, Martin Post, Stephen Lye
  • Method for diagnosing increased risk of preeclampsia
    Patent number: 7445940
    Abstract: Methods are provided for the diagnosis and treatment of patients with increased risk of preeclampsia. The methods involve measuring levels of TGF-beta 3, receptors of cytokines of the TG beta family, or HIF-1 alpha.
    Type: Grant
    Filed: January 26, 2005
    Date of Patent: November 4, 2008
    Assignee: Mount Sinai Hospital
    Inventors: Isabella Caniggia, Martin Post, Stephen Lye
  • Methods to diagnose a required regulation of trophoblast invasion
    Publication number: 20050136468
    Abstract: Methods are provided for the diagnosis and treatment of patients with increased risk of preeclampsia. The methods involve measuring levels of TGF-beta 3, receptors of cytokines of the TG beta family, or HIF-1 alpha.
    Type: Application
    Filed: January 26, 2005
    Publication date: June 23, 2005
    Applicants: Mount Sinai Hospital, Martin Post
    Inventors: Isabella Caniggia, Martin Post, Stephen Lye
  • Methods to diagnose a required regulation of trophoblast invasion
    Patent number: 6863880
    Abstract: Methods are provided for the diagnosis and treatment of patients with increased risk of preeclampsia. The methods involve measuring levels of TGF-?3, receptors of cytokines of the TG? family, or HIF-1?.
    Type: Grant
    Filed: December 20, 2001
    Date of Patent: March 8, 2005
    Assignees: Mount Sinal Hospital, Martin Post
    Inventors: Isabella Caniggia, Martin Post, Stephen Lye
  • Methods to diagnose a required regulation of trophoblast invasion
    Publication number: 20020110833
    Abstract: Methods are provided for the diagnosis and treatment of patients with increased risk of preeclampsia. The methods involve measuring levels of TGF-&bgr;3, receptors of cytokines of the TG&bgr; family, or HIF-1&agr;.
    Type: Application
    Filed: December 20, 2001
    Publication date: August 15, 2002
    Applicant: Mount Sinai Hospital Corporation
    Inventors: Isabella Caniggia, Martin Post, Stephen Lye
  • Methods to diagnose a required regulation of trophoblast invasion
    Patent number: 6376199
    Abstract: Methods are provided for the diagnosis and treatment of patients with increased risk of preeclampsia. The methods involve measuring levels of TGF-&bgr;3, receptors of cytokines of the TG&bgr; family, or HIF-1&agr;.
    Type: Grant
    Filed: December 21, 1999
    Date of Patent: April 23, 2002
    Assignees: The Hospital for Sick Children (HSC), Mount Sinai Hospital Corporation
    Inventors: Isabella Caniggia, Martin Post, Stephen Lye