Patents by Inventor Isabelle Alexandre

Isabelle Alexandre has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7205104
    Abstract: A method for identifying or quantifying an organism by a detecting its nucleotide sequence among at least 4 other homologous sequences comprising amplifying nucleic acids from the organism to generate target nucleotide sequences to be detected; contacting the target nucleotide sequences with single stranded capture nucleotide sequences bound by a single predetermined link to an insoluble solid support and discriminating the binding of a target nucleotide sequence specific of an organism with a signal resulting from a hybridization by complementary base pairing between the target nucleotide sequence and its corresponding capture nucleotide sequence is disclosed. The capture nucleotide sequence is bound to the insoluble solid support at a specific location on an array having a density of at least 4 different bound single stranded capture nucleotide sequences/cm2. The location of the signal on the array allows identification or quantification of the organism.
    Type: Grant
    Filed: March 23, 2001
    Date of Patent: April 17, 2007
    Assignee: Eppendorf Array Technologies SA (EAT)
    Inventors: José Remacle, Sandrine Hamels, Nathalie Zammatteo, Laurence Lockman, Sophie Dufour, Isabelle Alexandre, Francoise De Longueville
  • Patent number: 7202026
    Abstract: The present invention is related to an identification and/or quantification method of a large number of biological organisms groups at different levels (family, genus, species) or part of those (possibly present in a biological sample) by a detection of their nucleotide sequence.
    Type: Grant
    Filed: January 23, 2002
    Date of Patent: April 10, 2007
    Assignee: Eppendorf Array Technologies SA (EAT)
    Inventors: José Remacle, Sandrine Hamels, Nathalie Zammatteo, Laurence Lockman, Sophie Dufour, Isabelle Alexandre, Francoise De Longueville
  • Publication number: 20070037187
    Abstract: Disclosed is a system and method conducting real-time PCR. Unlabeled capture molecules of a specific design are immobilized on a solid support, and contacted with amplicons produced in one or more PCR cycles. Detection of amplicons may take place during or between the PCR cycles while the solid support is in fluidic contact with the PCR solution. In an alternate embodiment detection of the amplicons takes place when the solid support is not in fluidic contact with the PCR solution. The method is suitable for the simultaneous detection and quantification of closely homologous target molecules.
    Type: Application
    Filed: May 17, 2006
    Publication date: February 15, 2007
    Inventors: Isabelle Alexandre, Sylvain Margaine, Dieter Husar, Nathalie Zammatteo, Heinz Koehn, Jose Remacle
  • Publication number: 20060105354
    Abstract: The present invention relates to a method and apparatus for monitoring a real-time quantification of multiple target molecules during their binding on capture molecules of a micro-array. The method comprises the steps of: placing, in a chamber (14), a support (15) having fixed upon its surface a micro-array comprising at least 5 capture molecules (20) being immobilized in specifically localized areas (21) of said support; introducing said labeled target molecules solution (13) into the chamber; incubating said labeled target molecules under stable and controlled temperature conditions to allow the binding between said target and capture molecules; directing an excitation light (2) from a light source (1) on the surface of the micro-array; measuring the electromagnetic light emission (7) from the bound target molecules in response to said excitation light in presence of the solution containing the target molecules wherein the surface of emission for a localized area is comprised between about 0.
    Type: Application
    Filed: November 18, 2004
    Publication date: May 18, 2006
    Inventors: Jose Remacle, Isabelle Alexandre, Sylvain Margaine, Dieter Husar
  • Publication number: 20030198943
    Abstract: The present invention is related to an identification and/or quantification method of a large number of biological organisms groups at different levels (family, genus, species) or part of those (possibly present in a biological sample) by a detection of their nucleotide sequence.
    Type: Application
    Filed: January 23, 2002
    Publication date: October 23, 2003
    Inventors: Jose Remacle, Sandrine Hamels, Nathalie Zammatteo, Laurence Lockman, Sophie Dufour, Isabelle Alexandre, Francoise De Longueville
  • Publication number: 20030124522
    Abstract: The present invention is related to a method for the identification and/or the quantification of a target compound obtained from a sample, preferably a biological sample, comprising the steps of:
    Type: Application
    Filed: May 19, 2000
    Publication date: July 3, 2003
    Inventors: Jose Remacle, Joseph Demarteau, Nathalie Zammatteo, Isabelle Alexandre, Sandrine Hamels, Yves Houbion, Francoise De Longueville
  • Publication number: 20020177144
    Abstract: The present invention is related to a method for the detection and/or the quantification of a target molecule by its binding with a non-cleavable capture molecule fixed on the surface of a disc comprising registered data.
    Type: Application
    Filed: December 27, 2001
    Publication date: November 28, 2002
    Inventors: Jose Remacle, Isabelle Alexandre, Yves Houbion
  • Publication number: 20020106646
    Abstract: The present invention is related to an identification and/or quantification method of a biological (micro)organism or part of it (possibly present in a biological sample) by a detection of its nucleotide sequence among at least 4 other homologous sequences and comprising the steps of:
    Type: Application
    Filed: March 23, 2001
    Publication date: August 8, 2002
    Inventors: Jose Remacle, Sandrine Hamels, Nathalie Zammatteo, Laurence Lockman, Sophie Dufour, Isabelle Alexandre, Francoise De Longueville