Patents by Inventor Isabelle André

Isabelle André has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for generating T-cell progenitors
    Patent number: 12071635
    Abstract: The invention relates to the field of cell therapy and to an in vitro method for generating T-cell progenitors, comprising the step of exposing CD34+ cells in a medium containing a Notch ligand, a soluble domain of the Delta-like ligand 4, joined to an Fc region of a protein IgG, in the presence of a fragment of fibronectin comprising the motifs RGDS and CS-1 and a heparin-binding domain.
    Type: Grant
    Filed: October 5, 2015
    Date of Patent: August 27, 2024
    Assignees: ASSISTANCE PUBLIQUE-HOPITAUX DE PARIS, FONDATION IMAGINE-INSTITUT DES MALADIES GÉNÉTIQUES, UNIVERSITÉCITÉ, INSTITUT NATIONAL DE LA SANTÉET DE LA RECHERCHE MÉDICALE (INSERM)
    Inventors: Marina Cavazzana, Isabelle André, Chantal Lagresle-Peyrou, Salima Hacein-Bey-Abina, Christian Reimann, Corinne De Chappedelaine, Emmanuelle Six
  • SYNTHESIS OF ENANTIOPURE CIS-A-IRONE FROM A RENEWABLE CARBON SOURCE
    Publication number: 20240240209
    Abstract: Synthesis of enantiopure cis-?-irone from a renewable carbon source Disclosed herein are natural and synthetic enzymes capable of performing a method of producing cis-?-irone. The method comprises providing an enzyme capable of converting psi-ionone to cis-?-irone; and contacting the enzyme and psi-ionone under suitable conditions to produce cis-?-irone. The enzyme may be a methyltransferase from Streptomyces albireticuli (SaMT), a promiscuous bifunctional methyltransferase/cyclase (pMT1) enzyme from Streptomyces, or a modified pMT1 enzyme with at least one substitution. The enzymes allow the in-vivo and in-vitro production of cis-?-irone including the use of glucose as feedstock for the biotransformation into cis-?-irone.
    Type: Application
    Filed: April 20, 2022
    Publication date: July 18, 2024
    Inventors: Xixian CHEN, Congqiang ZHANG, Rehka T, Sudha SHUKAL, Derek SMITH, Isabelle ANDRÉ, Esque JEREMY
  • METHOD FOR GENERATING T CELLS PROGENITORS
    Publication number: 20230293586
    Abstract: The invention relates to an in vitro method to generate T cell progenitors, comprising the step of culturing CD34+ cells in a medium containing TNF-alpha and/or an antagonist of the Aryl hydrocarbon/Dioxin receptor, in particular StemRegenin 1 (SR1), in presence of a Notch ligand and optionally a fibronectin fragment.
    Type: Application
    Filed: April 6, 2023
    Publication date: September 21, 2023
    Applicants: Assistance Publique - Hopitaux de Paris, Fondation Imagine - Institut des Maladies Génétiques, Université Paris Cité, Institut National de la Santé et de la Recherche Médicale (INSERM)
    Inventors: Isabelle ANDRÉ, Marina CAVAZZANA, Kuiying MA, John TCHEN, Tayebeh-Shabi SOHEILI, Ranjita Devi MOIRANGTHEM
  • Method for generating T cell progenitors
    Patent number: 11642376
    Abstract: The invention relates to an in vitro method to generate T cell progenitors, comprising the step of culturing CD34+ cells in a medium containing TNF-alpha and/or an antagonist of the Aryl hydro-carbon/Dioxin receptor, in particular StemRegenin 1 (SR1), in presence of a Notch ligand and optionally a fibronectin fragment.
    Type: Grant
    Filed: February 11, 2021
    Date of Patent: May 9, 2023
    Assignees: Assistance Publique—Hopitaux de Paris, Fondation Imagine—Institut des Maladies Génétiques, Université de Paris Cité, Institut National de la Santé et de la Recherche Médicale (INSERM)
    Inventors: Isabelle André, Marina Cavazzana, Kuiying Ma, John Tchen, Tayebeh-Shabi Soheili, Ranjita Devi Moirangthem
  • Method for generating T cells progenitors
    Patent number: 11638723
    Abstract: The invention relates to an in vitro method to generate T cell progenitors, comprising the step of culturing CD34+ cells in a medium containing TNF-alpha and/or an antagonist of the Aryl hydrocarbon/Dioxin receptor, in particular StemRegenin 1 (SR1), in presence of a Notch ligand and optionally a fibronectin fragment.
    Type: Grant
    Filed: February 11, 2021
    Date of Patent: May 2, 2023
    Assignees: Assistance Publique—Hopitaux de Paris, Fondation Imagine—Institut des Maladies Génétiques, Université Paris Cité, Institut National de la Santé et de la Recherche Médicale (INSERM)
    Inventors: Isabelle André, Marina Cavazzana, Kuiying Ma, John Tchen, Tayebeh-Shabi Soheili, Ranjita Devi Moirangthem
  • Method for generating T cells progenitors
    Patent number: 11426430
    Abstract: The invention relates to an in vitro method to generate T cell progenitors, comprising the step of culturing CD34+ cells in a medium containing TNF-alpha and/or an antagonist of the Aryl hydro-carbon/Dioxin receptor, in particular StemRegenin 1 (SR1), in presence of a Notch ligand and optionally a fibronectin fragment.
    Type: Grant
    Filed: September 2, 2020
    Date of Patent: August 30, 2022
    Assignees: Assistance Publique—Hopitaux de Paris, Fondation Imagine—Institut des Maladies Génétiques, UniversitéParis Cite, Institut National de la Santé et de la Recherche Médicale (INSERM)
    Inventors: Isabelle André, Marina Cavazzana, Kuiying Ma, John Tchen, Tayebeh-Shabi Soheili, Ranjita Devi Moirangthem
  • METHOD FOR GENERATING T CELLS PROGENITORS
    Publication number: 20210169934
    Abstract: The invention relates to an in vitro method to generate T cell progenitors, comprising the step of culturing CD34+ cells in a medium containing TNF-alpha and/or an antagonist of the Aryl hydrocarbon/Dioxin receptor, in particular StemRegenin 1 (SR1), in presence of a Notch ligand and optionally a fibronectin fragment.
    Type: Application
    Filed: February 11, 2021
    Publication date: June 10, 2021
    Applicants: Assistance Publique - Hopitaux de Paris, Fondation Imagine - Institut des Maladies Génétiques, Université de Paris, Institut National de la Santé et de la Recherche Médicale (INSERM)
    Inventors: Isabelle André, Marina Cavazzana, Kuiying Ma, John Tchen
  • METHOD FOR GENERATING T CELLS PROGENITORS
    Publication number: 20210169935
    Abstract: The invention relates to an in vitro method to generate T cell progenitors, comprising the step of culturing CD34+ cells in a medium containing TNF-alpha and/or an antagonist of the Aryl hydro-carbon/Dioxin receptor, in particular StemRegenin 1 (SR1), in presence of a Notch ligand and optionally a fibronectin fragment.
    Type: Application
    Filed: February 11, 2021
    Publication date: June 10, 2021
    Applicants: Assistance Publique - Hopitaux de Paris, Fondation Imagine - Institut des Maladies Génétiques, Université de Paris, Institut National de la Santé et de la Recherche Médicale (INSERM)
    Inventors: Isabelle André, Marina Cavazzana, Kuiying Ma, John Tchen
  • METHOD FOR GENERATING T CELLS PROGENITORS
    Publication number: 20200390817
    Abstract: The invention relates to an in vitro method to generate T cell progenitors, comprising the step of culturing CD34+ cells in a medium containing TNF-alpha and/or an antagonist of the Aryl hydro-carbon/Dioxin receptor, in particular StemRegenin 1 (SR1), in presence of a Notch ligand and optionally a fibronectin fragment.
    Type: Application
    Filed: September 2, 2020
    Publication date: December 17, 2020
    Applicants: Assistance Publique - Hopitaux de Paris, Fondation Imagine - Institut des Maladies Génétiques, Université de Paris, Institut National de la Santé et de la Recherche Médicale (INSERM)
    Inventors: Isabelle André, Marina Cavazzana, Kuiying Ma, John Tchen
  • METHOD FOR GENERATING T CELLS PROGENITORS
    Publication number: 20200046767
    Abstract: The invention relates to an in vitro method to generate T cell progenitors, comprising the step of culturing CD34+ cells in a medium containing TNF-alpha and/or an antagonist of the Aryl hydro-carbon/Dioxin receptor, in particular StemRegenin 1 (SR1), in presence of a Notch ligand and optionally a fibronectin fragment.
    Type: Application
    Filed: February 12, 2018
    Publication date: February 13, 2020
    Applicants: Assistance Publique - Hopitaux de Paris, Fondation Imagine - Institut des Maladies Génétiques, Université Paris Descartes, Institut National de la Santé et de la Recherche Médicale (INSERM)
    Inventors: Isabelle André, Marina Cavazzana, Kuiying Ma, John Tchen