Patents by Inventor Isabelle Andre

Isabelle Andre has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200390817
    Abstract: The invention relates to an in vitro method to generate T cell progenitors, comprising the step of culturing CD34+ cells in a medium containing TNF-alpha and/or an antagonist of the Aryl hydro-carbon/Dioxin receptor, in particular StemRegenin 1 (SR1), in presence of a Notch ligand and optionally a fibronectin fragment.
    Type: Application
    Filed: September 2, 2020
    Publication date: December 17, 2020
    Applicants: Assistance Publique - Hopitaux de Paris, Fondation Imagine - Institut des Maladies Génétiques, Université de Paris, Institut National de la Santé et de la Recherche Médicale (INSERM)
    Inventors: Isabelle André, Marina Cavazzana, Kuiying Ma, John Tchen
  • Publication number: 20200385698
    Abstract: The present invention relates to novel proteases, more particularly to protease variants having improved activity compared to the protease of SEQ ID NO: 1 and the uses thereof for degrading polyester containing material, such as plastic products. The proteases of the invention are particularly suited to degrade polylactic acid, and material containing polylactic acid.
    Type: Application
    Filed: December 21, 2018
    Publication date: December 10, 2020
    Inventors: ALAIN MARTY, SOPHIE DUQUESNE, MARIE GUICHERD, MARC GUEROULT, ISABELLE ANDRE
  • Publication number: 20200277585
    Abstract: The present invention relates to novel esterase, more particularly to esterase variants having improved activity compared to the esterase of SEQ ID No 1 and the uses thereof for degrading polyester containing material, such as plastic products. The esterases of the invention are particularly suited to degrade polyethylene terephthalate, and material containing polyethylene terephthalate.
    Type: Application
    Filed: March 16, 2020
    Publication date: September 3, 2020
    Inventors: VINCENT TOURNIER, HÉLÈNE TEXIER, MARIE-LAURE DESROUSSEAUX, CHRISTOPHER TOPHAM, ISABELLE ANDRE, SOPHIE BARBE, SOPHIE DUQUESNE, ALAIN MARTY
  • Publication number: 20200270591
    Abstract: The present invention relates to novel esterase, more particularly to esterase variants having improved thermostability compared to the esterase of SEQ ID No 1 and the uses thereof for degrading polyester containing material, such as plastic products. The esterases of the invention are particularly suited to degrade polyethylene terephthalate, and material containing polyethylene terephthalate.
    Type: Application
    Filed: March 9, 2020
    Publication date: August 27, 2020
    Inventors: CHRISTOPHER TOPHAM, HÉLÈNE TEXIER, VINCENT TOURNIER, MARIE-LAURE DESROUSSEAUX, SOPHIE DUQUESNE, ISABELLE ANDRE, SOPHIE BARBE, ALAIN MARTY
  • Patent number: 10696995
    Abstract: The present invention relates to a method for producing a glycosylated synthon or a monomer. Said method includes at least one step of placing at least one glycan-saccharase in the presence of at least one hydroxylated synthon and at least one saccharose. The invention also relates to a method for producing a glyco(co)polymer, including polymerizing at least two monomers separately obtained from the enzymatic glycosylation method according to the invention, and to a method for producing a glyco(co)polymer, preferably a block glyco(co)polymer, including coupling at least two monomers separately obtained from the enzymatic glycosylation method according to the invention.
    Type: Grant
    Filed: March 17, 2016
    Date of Patent: June 30, 2020
    Assignees: INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT, INSTITUT NATIONAL DES SCIENCES APPIQUEES DE TOULOUSE (INSAT), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE DE BORDEAUX, INSTITUT POLYTECHNIQUE DE BORDEAUX
    Inventors: Isabelle Andre, Stephane Grelier, David Guieysse, Alvaro Lafraya, Pierre Monsan, Claire Moulis, Frederic Peruch, Magali Remaud-Simeon, Marlene Vuillemin
  • Publication number: 20200165285
    Abstract: The present invention provides protected tetrasaccharides, their process of preparation and their use in the synthesis of oligosaccharides, in particular fragments of O-antigens from Shigella flexneri, for example of serotype 1a, 1b, 2a, 2b, 3a, X, 4a, 4b, 5a, 5b, 7a or 7b.
    Type: Application
    Filed: July 3, 2018
    Publication date: May 28, 2020
    Inventors: Laurence MULARD, Guillaume LE HEIGET, Zhaohu HU, Louis-Antoine BAREL, Isabelle ANDRE, Claire MOULIS, Magali REMAUD-SIMEON, Sophie BARBE, Mounir BENKOULOUCHE, Akli BEN IMEDDOURENE
  • Patent number: 10647739
    Abstract: The invention relates to a method for producing derivatives of O-?-glucosylated flavonoid, comprising at least one step of incubating a glucansucrase with a flavonoid and at least one sucrose, the flavonoid being a flavonoid which is monohydroxylated or hydroxylated in a non-vicinal manner on the B cycle. The invention also relates to novel O-?-glucosylated flavonoid derivatives, and to the use thereof.
    Type: Grant
    Filed: March 24, 2015
    Date of Patent: May 12, 2020
    Assignees: INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE, INSTITUTE NATIONAL DES SCIENCES APPLIQUEES DE TOULOUSE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Sandrine Morel, Isabelle Andre, Yoan Brison, Emmanuelle Cambon, Yannick Malbert, Denis Pompon, Magali Remaud-Simeon, Philippe Urban
  • Patent number: 10590401
    Abstract: The present invention relates to novel esterase, more particularly to esterase variants having improved activity compared to the esterase of SEQ ID NO: 1 and the uses thereof for degrading polyester containing material, such as plastic products. The esterases of the invention are particularly suited to degrade polyethylene terephthalate, and material containing polyethylene terephthalate.
    Type: Grant
    Filed: July 12, 2017
    Date of Patent: March 17, 2020
    Assignee: CARBIOS
    Inventors: Vincent Tournier, Helene Texier, Marie-Laure Desrousseaux, Christopher Topham, Isabelle Andre, Sophie Barbe, Sophie Duquesne, Alain Marty
  • Patent number: 10584320
    Abstract: The present invention relates to novel esterase, more particularly to esterase variants having improved thermostability compared to the esterase of SEQ ID NO: 1 and the uses thereof for degrading polyester containing material, such as plastic products. The esterases of the invention are particularly suited to degrade polyethylene terephthalate, and material containing polyethylene terephthalate.
    Type: Grant
    Filed: July 12, 2017
    Date of Patent: March 10, 2020
    Assignee: CARBIOS
    Inventors: Christopher Topham, Helene Texier, Vincent Tournier, Marie-Laure Desrousseaux, Sophie Duquesne, Isabelle Andre, Sophie Barbe, Alain Marty
  • Publication number: 20200046767
    Abstract: The invention relates to an in vitro method to generate T cell progenitors, comprising the step of culturing CD34+ cells in a medium containing TNF-alpha and/or an antagonist of the Aryl hydro-carbon/Dioxin receptor, in particular StemRegenin 1 (SR1), in presence of a Notch ligand and optionally a fibronectin fragment.
    Type: Application
    Filed: February 12, 2018
    Publication date: February 13, 2020
    Applicants: Assistance Publique - Hopitaux de Paris, Fondation Imagine - Institut des Maladies Génétiques, Université Paris Descartes, Institut National de la Santé et de la Recherche Médicale (INSERM)
    Inventors: Isabelle André, Marina Cavazzana, Kuiying Ma, John Tchen
  • Publication number: 20200017892
    Abstract: Embodiments of the present disclosure relate to mutant yeast strains, in particular mutant Yarrowia strains, capable of producing medium chain fatty acids compared to the parent oleaginous yeast strain from which said mutant oleaginous yeast strain derives. Embodiments of the present disclosure also relate to means and methods for obtaining these mutant yeast strains.
    Type: Application
    Filed: January 8, 2018
    Publication date: January 16, 2020
    Applicants: INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE, INSTITUT NATIONAL DES SCIENCES APPLIQUEES DE TOULOUSE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Florence Bordes, Coraline Rigouin, Alain Marty, Marc Gueroult, Isabelle Andre, Sophie Barbe, Benjamin Percheron, Christian Croux, Fayza Daboussi
  • Publication number: 20190233803
    Abstract: The present invention relates to novel esterase, more particularly to esterase variants having improved thermostability compared to the esterase of SEQ ID NO: 1 and the uses thereof for degrading polyester containing material, such as plastic products. The esterases of the invention are particularly suited to degrade polyethylene terephthalate, and material containing polyethylene terephthalate.
    Type: Application
    Filed: July 12, 2017
    Publication date: August 1, 2019
    Inventors: Christopher TOPHAM, Helene TEXIER, Vincent TOURNIER, Marie-Laure DESROUSSEAUX, Sophie DUQUESNE, Isabelle ANDRE, Sophie BARBE, Alain MARTY
  • Publication number: 20190225954
    Abstract: The present invention relates to novel esterase, more particularly to esterase variants having improved activity compared to the esterase of SECS ID NO: 1 and the uses thereof for degrading polyester containing material, such as plastic products. The esterases of the invention are particularly suited to degrade polyethylene terephthalate, and material containing polyethylene terephthalate.
    Type: Application
    Filed: July 12, 2017
    Publication date: July 25, 2019
    Applicant: CARBIOS
    Inventors: VINCENT TOURNIER, HELENE TEXIER, MARIE-LAURE DESROUSSEAUX, CHRISTOPHER TOPHAM, ISABELLE ANDRE, SOPHIE BARBE, SOPHIE DUQUESNE, ALAIN MARTY
  • Patent number: 10358663
    Abstract: A method of producing 2,4-dihydroxybutyric acid (2,4-DHB) by a synthetic pathway that includes transforming malate into 4-phospho-malate using a malate kinase, then transforming 4-phospho-malate into malate-4-semialdehyde using a malate semialdehyde dehydrogenase, and then transforming malate-4-semialdehyde into 2,4-DHB using a DHB dehydrogenase.
    Type: Grant
    Filed: November 18, 2015
    Date of Patent: July 23, 2019
    Assignee: ADISSEO FRANCE S.A.S.
    Inventors: Thomas Walther, Helene Cordier, Christopher Topham, Isabelle Andre, Magali Remaud-Simeon, Robert Huet, Jean-Marie Francois
  • Publication number: 20180258456
    Abstract: The present invention relates to a method for producing a glycosylated synthon or a monomer. Said method includes at least one step of placing at least one glycan-saccharase in the presence of at least one hydroxylated synthon and at least one saccharose. The invention also relates to a method for producing a glyco(co)polymer, including polymerizing at least two monomers separately obtained from the enzymatic glycosylation method according to the invention, and to a method for producing a glyco(co)polymer, preferably a block glyco(co)polymer, including coupling at least two monomers separately obtained from the enzymatic glycosylation method according to the invention.
    Type: Application
    Filed: March 17, 2016
    Publication date: September 13, 2018
    Inventors: Isabelle Andre, Stephane Grelier, David Guieysse, Alvaro Lafraya, Pierre Monsan, Claire Moulis, Frederic Peruch, Magali Remaud-Simeon, Marlene Vuillemin
  • Publication number: 20180208895
    Abstract: The invention relates to the field of cell therapy and to an in vitro method for generating T-cell progenitors, comprising the step of exposing CD34+ cells in a medium containing a Notch ligand, a soluble domain of the Delta-like ligand 4, joined to an Fc region of a protein IgG, in the presence of a fragment of fibronectin comprising the motifs RGDS and CS-1 and a heparin-binding domain.
    Type: Application
    Filed: October 5, 2015
    Publication date: July 26, 2018
    Applicants: Assistance Publique - Hopitaux de Paris, Fondation Imagine - Institut Des Maladies Genetiques, Universite Paris Descartes, Institut National de la Sante et de la Recherche Medicale
    Inventors: Marina Cavazzana-Calvo, Isabelle Andre-Schmutz, Chantal Lagresle-Peyrou, Salima Hacein-Bey-Abina, Christian Reimann, Chantal De Chappedelaine
  • Publication number: 20170107242
    Abstract: The invention relates to a method for producing derivatives of O-?-glucosylated flavonoid, comprising at least one step of incubating a glucansucrase with a flavonoid and at least one sucrose, the flavonoid being a flavonoid which is monohydroxylated or hydroxylated in a non-vicinal manner on the B cycle. The invention also relates to novel O-?-glucosylated flavonoid derivatives, and to the use thereof.
    Type: Application
    Filed: March 24, 2015
    Publication date: April 20, 2017
    Applicants: Institut National de la Recherche Agronomique, Institut National des Sciences Appliquees de Toulouse, Centre National de la Recherche Scientifique
    Inventors: Sandrine Morel, Isabelle Andre, Yoan Brison, Emmanuelle Cambon, Yannick Malbert, Denis Pompon, Magali Remaud-Simeon, Philippe Urban
  • Publication number: 20160153013
    Abstract: A method of producing 2,4-dihydroxybutyric acid (2,4-DHB) by a synthetic pathway that includes transforming malate into 4-phospho-malate using a malate kinase, then transforming 4-phospho-malate into malate-4-semialdehyde using a malate semialdehyde dehydrogenase, and then transforming malate-4-semialdehyde into 2,4-DHB using a DHB dehydrogenase.
    Type: Application
    Filed: November 18, 2015
    Publication date: June 2, 2016
    Inventors: Thomas WALTHER, Helene CORDIER, Christopher TOPHAM, Isabelle ANDRE, Magali REMAUD-SIMEON, Robert HUET, Jean-Marie FRANCOIS
  • Patent number: 9238829
    Abstract: A method of producing 2,4-dihydroxybutyric acid (2,4-DHB) by a synthetic pathway that includes the transforming malate in 4-phospho-malate using a malate kinase, said 4-phospho-malate being transformed in malate-4-semialdehyde using a malate semialdehyde dehydrogenase and said malate-4-semialdehyde being transformed in 2,4-DHB using a DHB dehydrogenase.
    Type: Grant
    Filed: October 27, 2011
    Date of Patent: January 19, 2016
    Assignee: ADISSEO FRANCE S.A.S.
    Inventors: Thomas Walther, Helene Cordier, Christopher Topham, Isabelle Andre, Magali Remaud-Simeon, Robert Huet, Jean-Marie Francois
  • Publication number: 20130273623
    Abstract: The present invention deals with a method of producing 2,4-dihydroxybutyric acid (2,4-DHB) by a synthetic pathway comprising the transformation of malate in 4-phospho-malate using a malate kinase, said 4-phospho-malate being transformed in malate-4-semialdehyde using a malate semialdehyde dehydrogenase and said malate-4-semialdehyde being transformed in 2,4-DHB using a DHB dehydrogenase.
    Type: Application
    Filed: October 27, 2011
    Publication date: October 17, 2013
    Applicant: ADISSEO FRANCE S.A.S.
    Inventors: Thomas Walther, Hélène Cordier, Christopher Topham, Isabelle Andre, Magali Remaud-Simeon, Robert Huet, Jean-Marie Francois