Patents by Inventor Isabelle Andre

Isabelle Andre has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS OF INDUCING CELL DEATH OF A POPULATION OF SOLID TUMOR CELLS
    Publication number: 20250084389
    Abstract: It was previously demonstrated that the RAC2 G12R mutation rapidly induced HSPCs cell death and hematopoiesis regulation. Now, the invention evaluated the impact of said mutation on three tumor cell lines: MDA-MB-231 (mammary gland adeno-carcinoma), HT29 (colorectal adenocarcinoma) and HepG2 (hepatocellular carcinoma). Briefly, cells were transduced with a lentiviral vector containing the green fluorescent protein (GFP) reporter cDNA (WPI) or a wild type form of RAC2 cDNA (WT) or a RAC2 mutated cDNA form (G12R). The inventors showed that the number of GFP+ cells is drastically lower in the G12R condition as compared to the WT and WPI conditions. The cell morphology and content are particularly disrupted. These observations were confirmed in a time-course proliferation assay performed on MDA-MB-231 and HT29 cell lines. Altogether, these data underlie the deleterious impact of the RAC2 G12R mutation on tumor cell lines proliferation.
    Type: Application
    Filed: January 16, 2023
    Publication date: March 13, 2025
    Inventors: Chantal LAGRESLE-PEYROU, Marina CAVAZZANA, Isabelle ANDRE, Boris BESSOT, Nataël SOREL
  • NOVEL ESTERASES AND USES THEREOF
    Publication number: 20250027063
    Abstract: The present invention relates to novel esterases, more particularly to esterase variants having improved activity and/or improved thermostability compared to the parent esterase of SEQ ID NO:1 or SEQ ID NO:2 and the uses thereof for degrading polyester containing material, such as plastic products. The esterases of the invention are particularly suited to degrade polyethylene terephthalate, and material containing polyethylene terephthalate.
    Type: Application
    Filed: November 15, 2022
    Publication date: January 23, 2025
    Inventors: GUY LIPPENS, CYRIL CHARLIER, MAHER BEN KHALED, ISABELLE ANDRE, MARC GUEROULT
  • NOVEL ESTERASES AND USES THEREOF
    Publication number: 20250019679
    Abstract: The present invention relates to novel esterase, more particularly to esterase variants having improved thermostability compared to the esterase of SEQ ID No 1 and the uses thereof for degrading polyester containing material, such as plastic products. The esterases of the invention are particularly suited to degrade polyethylene terephthalate, and material containing polyethylene terephthalate.
    Type: Application
    Filed: September 19, 2024
    Publication date: January 16, 2025
    Inventors: CHRISTOPHER TOPHAM, HÉLÈNE TEXIER, VINCENT TOURNIER, MARIE-LAURE DESROUSSEAUX, SOPHIE DUQUESNE, ISABELLE ANDRE, SOPHIE BARBE, ALAIN MARTY
  • ESTERASES AND USES THEREOF
    Publication number: 20250019678
    Abstract: The present invention relates to novel esterases, more particularly to esterase variants having improved activity and/or improved thermostability compared to the parent esterase of SEQ ID NO:1, SEQ ID NO:2 or SEQ ID NO:3 in acidic conditions and the uses thereof for degrading polyester containing material, such as plastic products. The esterases of the invention are particularly suited to degrade polyethylene terephthalate, and material containing polyethylene terephthalate in acidic conditions.
    Type: Application
    Filed: November 15, 2022
    Publication date: January 16, 2025
    Inventors: ALAIN MARTY, ISABELLE ANDRE, GRÉGORY ARNAL, SOPHIE DUQUESNE, SABINE GAVALDA, MARC GUEROULT, VINCENT TOURNIER
  • NOVEL PROTEASES AND USES THEREOF
    Publication number: 20240327816
    Abstract: The present invention relates to novel proteases, more particularly to protease variants having improved activity compared to the protease of SEQ ID NO: 1 and the uses thereof for degrading polyester containing material, such as plastic products. The proteases of the invention are particularly suited to degrade polylactic acid, and material containing polylactic acid.
    Type: Application
    Filed: March 29, 2024
    Publication date: October 3, 2024
    Inventors: ALAIN MARTY, SOPHIE DUQUESNE, MARIE GUICHERD, MARC GUEROULT, ISABELLE ANDRE
  • Esterases and uses thereof
    Patent number: 12098398
    Abstract: The present invention relates to novel esterase, more particularly to esterase variants having improved thermostability compared to the esterase of SEQ ID No 1 and the uses thereof for degrading polyester containing material, such as plastic products. The esterases of the invention are particularly suited to degrade polyethylene terephthalate, and material containing polyethylene terephthalate.
    Type: Grant
    Filed: August 15, 2022
    Date of Patent: September 24, 2024
    Assignee: CARBIOS
    Inventors: Christopher Topham, Hélène Texier, Vincent Tournier, Marie-Laure Desrousseaux, Sophie Duquesne, Isabelle Andre, Sophie Barbe, Alain Marty
  • Method for generating T-cell progenitors
    Patent number: 12071635
    Abstract: The invention relates to the field of cell therapy and to an in vitro method for generating T-cell progenitors, comprising the step of exposing CD34+ cells in a medium containing a Notch ligand, a soluble domain of the Delta-like ligand 4, joined to an Fc region of a protein IgG, in the presence of a fragment of fibronectin comprising the motifs RGDS and CS-1 and a heparin-binding domain.
    Type: Grant
    Filed: October 5, 2015
    Date of Patent: August 27, 2024
    Assignees: ASSISTANCE PUBLIQUE-HOPITAUX DE PARIS, FONDATION IMAGINE-INSTITUT DES MALADIES GÉNÉTIQUES, UNIVERSITÉCITÉ, INSTITUT NATIONAL DE LA SANTÉET DE LA RECHERCHE MÉDICALE (INSERM)
    Inventors: Marina Cavazzana, Isabelle André, Chantal Lagresle-Peyrou, Salima Hacein-Bey-Abina, Christian Reimann, Corinne De Chappedelaine, Emmanuelle Six
  • SYNTHESIS OF ENANTIOPURE CIS-A-IRONE FROM A RENEWABLE CARBON SOURCE
    Publication number: 20240240209
    Abstract: Synthesis of enantiopure cis-?-irone from a renewable carbon source Disclosed herein are natural and synthetic enzymes capable of performing a method of producing cis-?-irone. The method comprises providing an enzyme capable of converting psi-ionone to cis-?-irone; and contacting the enzyme and psi-ionone under suitable conditions to produce cis-?-irone. The enzyme may be a methyltransferase from Streptomyces albireticuli (SaMT), a promiscuous bifunctional methyltransferase/cyclase (pMT1) enzyme from Streptomyces, or a modified pMT1 enzyme with at least one substitution. The enzymes allow the in-vivo and in-vitro production of cis-?-irone including the use of glucose as feedstock for the biotransformation into cis-?-irone.
    Type: Application
    Filed: April 20, 2022
    Publication date: July 18, 2024
    Inventors: Xixian CHEN, Congqiang ZHANG, Rehka T, Sudha SHUKAL, Derek SMITH, Isabelle ANDRÉ, Esque JEREMY
  • Esterases and uses thereof
    Patent number: 11926851
    Abstract: The present invention relates to esterases, more particularly to esterase variants having improved activity and/or improved thermostability compared to the esterase of SEQ ID NO: 1 and the uses thereof for degrading polyester containing material, such as plastic products. The esterases of the invention are particularly suited to degrade polyethylene terephthalate, and material containing polyethylene terephthalate.
    Type: Grant
    Filed: December 22, 2022
    Date of Patent: March 12, 2024
    Assignee: CARBIOS
    Inventors: Benoît David, Isabelle Andre, Maher Ben Khaled, Sophie Duquesne, Alain Marty
  • NOVEL PROTEASES AND USES THEREOF
    Publication number: 20240059859
    Abstract: The present invention relates to novel proteases, more particularly to protease variants having improved thermostability compared to the protease of SEQ ID NO: 1 and the uses thereof for degrading polyester containing material, such as plastic products. The proteases of the invention are particularly suited to degrade polylactic acid, and material containing polylactic acid.
    Type: Application
    Filed: December 21, 2021
    Publication date: February 22, 2024
    Inventors: YOUNES BOUCHIBA, ISABELLE ANDRE, SOPHIE BARBE, SOPHIE DUQUESNE
  • PROTECTED TETRASACCHARIDES, THEIR PROCESS OF PREPARATION AND THEIR USE AS TRANSGLUCOSYLASE ACCEPTOR SUBSTRATES IN THE CHEMO-ENZYMATIC SYNTHESIS OF SHIGELLA FLEXNERI SPECIFIC OLIGOSACCHARIDES
    Publication number: 20240002423
    Abstract: The present invention provides protected tetrasaccharides, their process of preparation and their use in the synthesis of oligosaccharides, in particular fragments of O-antigens from Shigella flexneri, for example of serotype 1a, 1b, 2a, 2b, 3a, X, 4a, 4b, 5a, 5b, 7a or 7b.
    Type: Application
    Filed: September 8, 2023
    Publication date: January 4, 2024
    Inventors: Laurence MULARD, Guillaume LE HEIGET, Zhaohu HU, Louis-Antoine BAREL, Isabelle ANDRE, Claire MOULIS, Magali REMAUD-SIMEON, Sophie BARBE, Mounir BENKOULOUCHE, Akli BEN IMEDDOURENE
  • Protected tetrasaccharides, their process of preparation and their use as transglucosylase acceptor substrates in the chemo-enzymatic synthesis of specific oligosaccharides
    Patent number: 11834468
    Abstract: The present invention provides protected tetrasaccharides, their process of preparation and their use in the synthesis of oligosaccharides, in particular fragments of O-antigens from Shigella flexneri, for example of serotype 1a, 1b, 2a, 2b, 3a, X, 4a, 4b, 5a, 5b, 7a or 7b.
    Type: Grant
    Filed: July 3, 2018
    Date of Patent: December 5, 2023
    Assignees: INSTITUT PASTEUR, INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE, INSTITUT NATIONAL DES SCIENCES APPLIQUEES DE TOULOUSE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Laurence Mulard, Guillaume Le Heiget, Zhaohu Hu, Louis-Antoine Barel, Isabelle Andre, Claire Moulis, Magali Remaud-Simeon, Sophie Barbe, Mounir Benkoulouche, Akli Ben Imeddourene
  • METHOD FOR GENERATING T CELLS PROGENITORS
    Publication number: 20230293586
    Abstract: The invention relates to an in vitro method to generate T cell progenitors, comprising the step of culturing CD34+ cells in a medium containing TNF-alpha and/or an antagonist of the Aryl hydrocarbon/Dioxin receptor, in particular StemRegenin 1 (SR1), in presence of a Notch ligand and optionally a fibronectin fragment.
    Type: Application
    Filed: April 6, 2023
    Publication date: September 21, 2023
    Applicants: Assistance Publique - Hopitaux de Paris, Fondation Imagine - Institut des Maladies Génétiques, Université Paris Cité, Institut National de la Santé et de la Recherche Médicale (INSERM)
    Inventors: Isabelle ANDRÉ, Marina CAVAZZANA, Kuiying MA, John TCHEN, Tayebeh-Shabi SOHEILI, Ranjita Devi MOIRANGTHEM
  • NOVEL ESTERASES AND USES THEREOF
    Publication number: 20230212537
    Abstract: The present invention relates to esterases, more particularly to esterase variants having improved activity and/or improved thermostability compared to the esterase of SEQ ID NO: 1 and the uses thereof for degrading polyester containing material, such as plastic products. The esterases of the invention are particularly suited to degrade polyethylene terephthalate, and material containing polyethylene terephthalate.
    Type: Application
    Filed: December 22, 2022
    Publication date: July 6, 2023
    Inventors: BENOÎT DAVID, ISABELLE ANDRE, MAHER BEN KHALED, SOPHIE DUQUESNE, ALAIN MARTY
  • Esterases and uses thereof
    Patent number: 11692181
    Abstract: The present invention relates to novel esterases, more particularly to esterase variants having improved activity and/or improved thermostability compared to the esterase of SEQ ID NO: 1 and the uses thereof for degrading polyester containing material, such as plastic products. The esterases of the invention are particularly suited to degrade polyethylene terephthalate, and material containing polyethylene terephthalate.
    Type: Grant
    Filed: July 26, 2019
    Date of Patent: July 4, 2023
    Assignee: CARBIOS
    Inventors: Isabelle Andre, Vincent Tournier, Alexandre Gilles, Sophie Duquesne
  • Method for generating T cell progenitors
    Patent number: 11642376
    Abstract: The invention relates to an in vitro method to generate T cell progenitors, comprising the step of culturing CD34+ cells in a medium containing TNF-alpha and/or an antagonist of the Aryl hydro-carbon/Dioxin receptor, in particular StemRegenin 1 (SR1), in presence of a Notch ligand and optionally a fibronectin fragment.
    Type: Grant
    Filed: February 11, 2021
    Date of Patent: May 9, 2023
    Assignees: Assistance Publique—Hopitaux de Paris, Fondation Imagine—Institut des Maladies Génétiques, Université de Paris Cité, Institut National de la Santé et de la Recherche Médicale (INSERM)
    Inventors: Isabelle André, Marina Cavazzana, Kuiying Ma, John Tchen, Tayebeh-Shabi Soheili, Ranjita Devi Moirangthem
  • NOVEL ESTERASES AND USES THEREOF
    Publication number: 20230135014
    Abstract: The present invention relates to novel esterase, more particularly to esterase variants having improved thermostability compared to the esterase of SEQ ID No 1 and the uses thereof for degrading polyester containing material, such as plastic products. The esterases of the invention are particularly suited to degrade polyethylene terephthalate, and material containing polyethylene terephthalate.
    Type: Application
    Filed: August 15, 2022
    Publication date: May 4, 2023
    Inventors: CHRISTOPHER TOPHAM, HÉLÈNE TEXIER, VINCENT TOURNIER, MARIE-LAURE DESROUSSEAUX, SOPHIE DUQUESNE, ISABELLE ANDRE, SOPHIE BARBE, ALAIN MARTY
  • Method for generating T cells progenitors
    Patent number: 11638723
    Abstract: The invention relates to an in vitro method to generate T cell progenitors, comprising the step of culturing CD34+ cells in a medium containing TNF-alpha and/or an antagonist of the Aryl hydrocarbon/Dioxin receptor, in particular StemRegenin 1 (SR1), in presence of a Notch ligand and optionally a fibronectin fragment.
    Type: Grant
    Filed: February 11, 2021
    Date of Patent: May 2, 2023
    Assignees: Assistance Publique—Hopitaux de Paris, Fondation Imagine—Institut des Maladies Génétiques, Université Paris Cité, Institut National de la Santé et de la Recherche Médicale (INSERM)
    Inventors: Isabelle André, Marina Cavazzana, Kuiying Ma, John Tchen, Tayebeh-Shabi Soheili, Ranjita Devi Moirangthem
  • Proteases and uses thereof
    Patent number: 11549105
    Abstract: The present invention relates to novel proteases, more particularly to protease variants having improved activity compared to the protease of SEQ ID NO: 1 and the uses thereof for degrading polyester containing material, such as plastic products. The proteases of the invention are particularly suited to degrade polylactic acid, and material containing polylactic acid.
    Type: Grant
    Filed: December 21, 2018
    Date of Patent: January 10, 2023
    Assignee: CARBIOS
    Inventors: Alain Marty, Sophie Duquesne, Marie Guicherd, Marc Gueroult, Isabelle Andre
  • Esterases and uses thereof
    Patent number: 11535832
    Abstract: The present invention relates to esterases, more particularly to esterase variants having improved activity and/or improved themostability compared to the esterase of SEQ ID NO:1 and the uses thereof for degrading polyester containing material, such as plastic products. The esterases of the invention are particularly suited to degrade polyethylene terephthalate, and material containing polyethylene terephthalate.
    Type: Grant
    Filed: July 26, 2019
    Date of Patent: December 27, 2022
    Assignee: CARBIOS
    Inventors: Benoît David, Isabelle Andre, Maher Ben Khaled, Sophie Duquesne, Alain Marty