Patents by Inventor Isabelle Audo

Isabelle Audo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TREATMENT OF CONGENITAL STATIONARY NIGHT BLINDNESS USING GENE THERAPY
    Publication number: 20240092858
    Abstract: The present invention relates to an expression cassette allowing expression of a functional LRIT3 protein in mammal eyes; said expression cassette is inserted in an expression vector, preferably an adeno-associated virus (AAV); accordingly, the present invention further relates to a recombinant adeno-associated virus (AAV) vector carrying a nucleic acid sequence encoding a normal LRIT3 gene, or fragment thereof, under the control of regulatory sequences which express the product of the gene in the ocular cells, a pharmaceutically acceptable composition comprising such a recombinant AAV vector and to its use for the treatment of congenital stationary night blindness
    Type: Application
    Filed: December 8, 2020
    Publication date: March 21, 2024
    Applicants: SORBONNE UNIVERSITE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)
    Inventors: Christina Zeitz, Deniz Dalkara, Juliette Varin, Isabelle Audo, Serge Picaud, José-Alain Sahel
  • G-PROTEIN-GATED-K+ CHANNEL-MEDIATED ENHANCEMENTS IN LIGHT SENSITIVITY IN ROD-CONE DYSTROPHY (RCD)
    Publication number: 20230338581
    Abstract: The present invention concerns a new gene therapy approach to increase light-sensitivity in degenerating cones in advanced stages of rod-cone dystrophy (RCD) mediated by G-protein-gated-K+ channel (GIRK), in particular GIRK2, activated by G proteins recruited by cone opsin expressed in degenerating cones for use in the treatment of patients with RCD.
    Type: Application
    Filed: October 11, 2022
    Publication date: October 26, 2023
    Inventors: Deniz DALKARA, Cardillia-Joe SIMON, Stefan HERLITZE, José-Alain SAHEL, Isabelle AUDO, Serge PICAUD, Stéphane Bertin
  • G-PROTEIN-GATED-K+ CHANNEL-MEDIATED ENHANCEMENTS IN LIGHT SENSITIVITY IN ROD-CONE DYSTROPHY (RCD)
    Publication number: 20230159609
    Abstract: The present invention concerns a new gene therapy approach to increase light-sensitivity in degenerating cones in advanced stages of rod-cone dystrophy (RCD) mediated by G-protein-gated-K+ channel (GIRK), in particular GIRK2, activated by G proteins recruited by cone opsin expressed in degenerating cones.
    Type: Application
    Filed: July 10, 2020
    Publication date: May 25, 2023
    Inventors: Deniz DALKARA, Cardillia-Joe SIMON, Stefan HERLITZE, José-Alain SAHEL, Isabelle AUDO, Serge PICAUD, Stéphane Bertin
  • Mutations of the GPR179 Gene in Congenital Stationary Night Blindness
    Publication number: 20150031569
    Abstract: The present invention relates to an in vitro method for diagnosing a complete congenital stationary night blindness (cCSNB) in a subject, which method comprises determining the presence of an alteration in the GPR179 gene in a biological sample of said subject. Screening methods and therapeutic applications are further described.
    Type: Application
    Filed: January 23, 2013
    Publication date: January 29, 2015
    Inventors: Christina Zeitz, Isabelle Audo, Elise Orhan, Kinga Jakowska, Jose-Alain Sahel