Patents by Inventor Isabelle Barrette-Ng

Isabelle Barrette-Ng has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Streptavidin mutein exhibiting reversible binding for biotin and streptavidin binding peptide tagged proteins
    Patent number: 9353161
    Abstract: The present invention relates to a new streptavidin muteins. This mutein is binds both streptavidin binding peptide tagged and biotin or biotinylated molecules, and does so in a reversible fashion. As such, it is stable enough to allow reuse, and producible with reasonable production yield via secretion in a soluble functional state without the requirement of refolding via the tedious and expensive denaturation and renaturation processes.
    Type: Grant
    Filed: September 13, 2012
    Date of Patent: May 31, 2016
    Assignee: UTI LIMITED PARTNERSHIP
    Inventors: Sui-Lam Wong, Sau-Ching Wu, Isabelle Barrette-Ng, Kenneth K-S. Ng
  • STREPTAVIDIN MUTEIN EXHIBITING REVERSIBLE BINDING FOR BIOTIN AND STREPTAVIDIN BINDING PEPTIDE TAGGED PROTEINS
    Publication number: 20140378657
    Abstract: The present invention relates to a new streptavidin muteins. This mutein is binds both streptavidin binding peptide tagged and biotin or biotinylated molecules, and does so in a reversible fashion. As such, it is stable enough to allow reuse, and producible with reasonable production yield via secretion in a soluble functional state without the requirement of refolding via the tedious and expensive denaturation and renaturation processes.
    Type: Application
    Filed: September 13, 2012
    Publication date: December 25, 2014
    Applicant: UTI LIMITED PARTNERSHIP
    Inventors: Sui-Lam Wong, Sau-Ching Wu, Isabelle Barrette-Ng, Kenneth K-S. Ng
  • Tetrameric streptavidin mutein with reversible biotin binding capability
    Patent number: 8822640
    Abstract: The present invention relates to a new streptavidin muteins. This mutein is The muteins are capable of oligomerization to form tetramers, with relatively strong subunit interactions, dissociation constant (KD) for biotin in this mutein in the range of 10?7 to 10?8M, off-rate (koff) for the bound biotin in the streptavidin-biotin complex in the range of 10?4 sec?1, stable enough to allow reuse, and producible producable with reasonable production yield via secretion in a soluble functional state without the requirement of refolding streptavidin via the tedious and expensive denaturation and renaturation processes.
    Type: Grant
    Filed: October 13, 2011
    Date of Patent: September 2, 2014
    Assignee: UTI Limited Partnership
    Inventors: Sui-Lam Wong, Sau-Ching Wu, Isabelle Barrette-Ng, Ken Ng
  • Tetrameric Streptavidin Mutein With Reversible Biotin Binding Capability
    Publication number: 20130035471
    Abstract: The present invention relates to a new streptavidin muteins. This mutein is The muteins are capable of oligomerization to form tetramers, with relatively strong subunit interactions, dissociation constant (KD) for biotin in this mutein in the range of 10?7 to 10?8M, off-rate (koff) for the bound biotin in the streptavidin-biotin complex in the range of 10?4 sec?1, stable enough to allow reuse, and producible producable with reasonable production yield via secretion in a soluble functional state without the requirement of refolding streptavidin via the tedious and expensive denaturation and renaturation processes.
    Type: Application
    Filed: October 13, 2011
    Publication date: February 7, 2013
    Inventors: Sui-Lam Wong, Sau-Ching Wu, Isabelle Barrette-Ng, Ken Ng