Patents by Inventor Isabelle De Waziers

Isabelle De Waziers has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Mutant cytochrome P450 2B6 proteins and uses thereof
    Patent number: 9243231
    Abstract: The present invention to relates mutant human cytochrome P450 2B6 (CYP2B6) proteins, and fusion proteins comprising said mutant CYP2B6 proteins. In particular, fusion proteins comprising mutant CYP2B6 and NAPDH-cytochrome P450 reductase are provided. The invention also relates to methods of treatment of cancer and the use of said proteins and fusion proteins in the treatment of cancer, in particular via virus-directed enzyme prodrug therapy.
    Type: Grant
    Filed: May 4, 2012
    Date of Patent: January 26, 2016
    Assignee: Institut National de la Santé et de la Recherche Médicale (INSERM)
    Inventors: Isabelle De Waziers, Walid Touati, Monique Diry, Jean-Pierre Flinois, Patrick Dansette, Philippe Beaune
  • MUTANT CYTOCHROME P450 2B6 PROTEINS AND USES THEREOF
    Publication number: 20140127180
    Abstract: The present invention to relates mutant human cytochrome P450 2B6 (CYP2B6) proteins, and fusion proteins comprising said mutant CYP2B6 proteins. In particular, fusion proteins comprising mutant CYP2B6 and NAPDH-cytochrome P450 reductase are provided. The invention also relates to methods of treatment of cancer and the use of said proteins and fusion proteins in the treatment of cancer, in particular via virus-directed enzyme prodrug therapy.
    Type: Application
    Filed: May 4, 2012
    Publication date: May 8, 2014
    Applicant: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)
    Inventors: Isabelle De Waziers, Walid Touati, Monique Diry, Jean-Pierre Flinois, Patrick Dansette, Philippe Beaune
  • Cyp450-specific dna probes and primers, and biological applications thereof
    Publication number: 20040171015
    Abstract: The present application relates to a set of new cDNA probes which enables the specific and simultaneous detection of the main fourteen CYP450 isoforms, and to new primers specific to the probes. It also provides transfection vectors, genetically engineered cells and with amplification products derived therefrom. The present application notably encompasses any solid surface such as DNA filters or DNA chips which comprises a cDNA probe or an amplification product of the invention. The products provided thereby enables to evaluate the toxicity or pathogenicity of a product, and to predict drug in vivo interactions or efficiency.
    Type: Application
    Filed: December 11, 2003
    Publication date: September 2, 2004
    Inventors: Isabelle De Waziers, Corinne Couteau, Celine Gros, Arlette Moncion, Philippe Beaune