Patents by Inventor Isabelle Gloaguen

Isabelle Gloaguen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of screening for anti-obesity agents using ciliary neutrophic factor receptor
    Patent number: 6960558
    Abstract: The present invention relates to methods for screening for anti-obesity agents using the ciliary neutrophic factor receptor.
    Type: Grant
    Filed: January 31, 2003
    Date of Patent: November 1, 2005
    Assignee: Instituto di Recerche di Biologia Molecolare P. Angeletti S.p.A.
    Inventors: Gennaro Ciliberto, Isabelle Gloaguen, Annalise Di Marco, Anna Demartis, Ralph Laufer, Riccardo Cortese
  • Variant of ciliary neurotrophic factor and DNA encoding the variant
    Patent number: 6660467
    Abstract: The subject of the present invention are variants of ciliary neurotrophic factor with enhanced receptor selectivity (CNTFR), useful for the treatment of diseases and disorders including motor neuron diseases and muscle degenerative diseases. Another subject of the invention is to provide a method for identifying the above mentioned CNTF variants. The hCNTF variants with the amino acid substitutions in accordance with the present invention, have a reduced ability, as compared to the human CNTF, to elicit biological effects through soluble CNTFR, without affecting its ability to activate membrane-bound neuronal CNTF receptors, thereby improving its therapeutic properties. FIG. 1 shows the reduced CNTFR binding affinity of a CNTF variant according to the invention (IA-CNTF; SEQ ID NO: 2). It is evident that the binding affinity of this variant to the CNTFR is reduced as compared to the wild-type human CNTF molecule.
    Type: Grant
    Filed: September 20, 1999
    Date of Patent: December 9, 2003
    Assignee: Instituto di Ricerche di Biologia Molecolare P. Angeletti S.p.A.
    Inventors: Isabelle Gloaguen, Annalise Di Marco, Anna De Martis, Ralph Laufer, Isabella Saggio
  • Use of CNTF (ciliary neurotrophic factor) receptor activators for the treatment of obesity
    Publication number: 20030176346
    Abstract: The present invention refers to the use of hCNTF (human ciliary neurotrophic factor), mutants thereof or other molecules that activate the CNTF receptor, for the preparation of drugs for the treatment of obesity and associated diseases, for example hyperglycemia. FIG. 1 shows the anti-obesity effect of hCNTF and leptin on body weight (left panels) and on food intake (right panels) in genetically obese mice and in mice with diet-induced obesity (DIO).
    Type: Application
    Filed: January 31, 2003
    Publication date: September 18, 2003
    Applicant: Istituto di Ricerche di Biologia Molecolare P. Angeletti S.p.A.
    Inventors: Gennaro Ciliberto, Isabelle Gloaguen, Annalise Di Marco, Anna Demartis, Ralph Laufer, Riccardo Cortese
  • Use of CNTF (ciliary neurotrophic factor) receptor activators for the treatment of obesity
    Patent number: 6565869
    Abstract: The present invention refers to the use of hCNTF (human ciliary neurotrophic factor), mutants thereof or other molecules that activate the CNTF receptor, for the preparation of drugs for the treatment of obesity and associated disease, for example hyperglycemia. FIG. 1 shows the anti-obesity effect of hCNTF and leptin on body weight (left panels) and on food intake (right panels) in genetically obese mice and in mice with diet-induced obesity (DIO).
    Type: Grant
    Filed: July 19, 1999
    Date of Patent: May 20, 2003
    Assignee: Istituto di Ricerche di Biologia Molecolare P. Angeletti S.p.A.
    Inventors: Gennaro Ciliberto, Patrizia Costa, Giacomo Paonessa, Domenico Lazzaro, Isabelle Gloaguen, Annalise Di Marco, Anna De Martis, Ralph Laufer, Riccardo Cortese