Patents by Inventor Isabelle Lemire

Isabelle Lemire has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Bone delivery conjugates and method of using same to target proteins to bone
    Patent number: 11248021
    Abstract: A bone delivery conjugate having a structure selected from the group consisting of: A) X-Dn-Y-protein-Z; and B) Z-protein-Y-Dn-X, wherein X is absent or is an amino acid sequence of at least one amino acid; Y is absent or is an amino acid sequence of at least one amino acid; Z is absent or is an amino acid sequence of at least one amino acid; and Dn is a poly aspartate wherein n=10 to 16. Compositions comprising same and methods of use thereof.
    Type: Grant
    Filed: December 28, 2018
    Date of Patent: February 15, 2022
    Assignee: Alexion Pharmaceuticals, Inc.
    Inventors: Philippe Crine, Guy Boileau, Isabelle Lemire, Thomas P. Loisel
  • Methods for treating multiple osteochondroma (MO)
    Patent number: 10980778
    Abstract: The invention features methods for inhibiting the formation, reducing the size, and slowing the growth of an osteochondroma in a subject with multiple osteochondroma (MO) by administering to the subject palovarotene (also known as R667), or a pharmaceutically acceptable salt thereof. The methods described herein can also ameliorate complications associated with osteochondroma formation and growth in a subject with MO.
    Type: Grant
    Filed: November 16, 2017
    Date of Patent: April 20, 2021
    Assignee: Clementia Pharmaceuticals Inc.
    Inventors: Isabelle Lemire, Michael Harvey, Donna Roy Grogan, Clarissa Desjardins
  • METHODS FOR TREATING MULTIPLE OSTEOCHONDROMA (MO)
    Publication number: 20190275005
    Abstract: The invention features methods for inhibiting the formation, reducing the size, and slowing the growth of an osteochondroma in a subject with multiple osteochondroma (MO) by administering to the subject palovarotene (also known as R667), or a pharmaceutically acceptable salt thereof. The methods described herein can also ameliorate complications associated with osteochondroma formation and growth in a subject with MO.
    Type: Application
    Filed: November 16, 2017
    Publication date: September 12, 2019
    Inventors: Isabelle LEMIRE, Michael HARVEY, Donna Roy GROGAN, Clarissa DESJARDINS
  • BONE DELIVERY CONJUGATES AND METHOD OF USING SAME TO TARGET PROTEINS TO BONE
    Publication number: 20190119323
    Abstract: A bone delivery conjugate having a structure selected from the group consisting of: A) X-Dn-Y-protein-Z; and B) Z-protein-Y-Dn-X, wherein X is absent or is an amino acid sequence of at least one amino acid; Y is absent or is an amino acid sequence of at least one amino acid; Z is absent or is an amino acid sequence of at least one amino acid; and Dn is a poly aspartate wherein n=10 to 16. Compositions comprising same and methods of use thereof.
    Type: Application
    Filed: December 28, 2018
    Publication date: April 25, 2019
    Inventors: Philippe CRINE, Guy BOILEAU, Isabelle LEMIRE, Thomas P. LOISEL
  • Bone delivery conjugates and method of using same to target proteins to bone
    Patent number: 10000532
    Abstract: A bone delivery conjugate having a structure selected from the group consisting of: A) X-Dn-Y-protein-Z; and B) Z-protein-Y-Dn-X, wherein X is absent or is an amino acid sequence of at least one amino acid; Y is absent or is an amino acid sequence of at least one amino acid; Z is absent or is an amino acid sequence of at least one amino acid; and Dn is a poly aspartate wherein n=10 to 16. Compositions comprising same and methods of use thereof.
    Type: Grant
    Filed: December 15, 2009
    Date of Patent: June 19, 2018
    Assignee: Alexion Pharmaceuticals, Inc.
    Inventors: Philippe Crine, Guy Boileau, Isabelle Lemire, Thomas P. Loisel
  • BONE DELIVERY CONJUGATES AND METHOD OF USING SAME TO TARGET PROTEINS TO BONE
    Publication number: 20160052968
    Abstract: A bone delivery conjugate having a structure selected from the group consisting of: A) X-Dn-Y-protein-Z; and B) Z-protein-Y-Dn-X, wherein X is absent or is an amino acid sequence of at least one amino acid; Y is absent or is an amino acid sequence of at least one amino acid; Z is absent or is an amino acid sequence of at least one amino acid; and Dn is a poly aspartate wherein n=10 to 16. Compositions comprising same and methods of use thereof.
    Type: Application
    Filed: November 3, 2015
    Publication date: February 25, 2016
    Inventors: Philippe CRINE, Guy Boileau, Isabelle Lemire, Thomas P. Loisel
  • Bone delivery conjugates and method of using same to target proteins to bone
    Patent number: 7960529
    Abstract: A bone delivery conjugate having a structure selected from the group consisting of: A) X-Dn-Y-protein-Z; and B) Z-protein-Y-Dn-X, wherein X is absent or is an amino acid sequence of at least one amino acid; Y is absent or is an amino acid sequence of at least one amino acid; Z is absent or is an amino acid sequence of at least one amino acid; and Dn is a poly aspartate wherein n=10 to 16. Compositions comprising same and methods of use thereof.
    Type: Grant
    Filed: June 3, 2010
    Date of Patent: June 14, 2011
    Assignee: Enobia Pharma Inc.
    Inventors: Philippe Crine, Guy Boileau, Isabelle Lemire, Thomas P. Loisel
  • BONE TARGETED ALKALINE PHOSPHATASE, KITS AND METHODS OF USE THEREOF
    Publication number: 20100297119
    Abstract: A bone targeted alkaline phosphatase comprising a polypeptide having the structure: Z-sALP-Y-spacer-X-Wn-V, wherein sALP is the extracellular domain of the alkaline phosphatase; wherein V is absent or is an amino acid sequence of at least one amino acid; X is absent or is an amino acid sequence of at least one amino acid; Y is absent or is an amino acid sequence of at least one amino acid; Z is absent or is an amino acid sequence of at least one amino acid; and Wn is a polyaspartate or a polyglutamate wherein n=10 to 16. Kits and methods of use thereof.
    Type: Application
    Filed: May 12, 2008
    Publication date: November 25, 2010
    Inventors: Philippe Crine, Guy Boileau, Thomas P. Loisel, Isabelle Lemire, Pierre Léonard, Robert Heft, Hal Landy
  • BONE DELIVERY CONJUGATES AND METHOD OF USING SAME TO TARGET PROTEINS TO BONE
    Publication number: 20100240125
    Abstract: A bone delivery conjugate having a structure selected from the group consisting of: A) X-Dn-Y-protein-Z; and B) Z-protein-Y-Dn-X, wherein X is absent or is an amino acid sequence of at least one amino acid; Y is absent or is an amino acid sequence of at least one amino acid; Z is absent or is an amino acid sequence of at least one amino acid; and Dn is a poly aspartate wherein n=10 to 16. Compositions comprising same and methods of use thereof.
    Type: Application
    Filed: June 3, 2010
    Publication date: September 23, 2010
    Applicant: Enobia Pharma Inc.
    Inventors: Philippe CRINE, Guy Boileau, Isabelle Lemire, Thomas P. Loisel
  • BONE DELIVERY CONJUGATES AND METHOD OF USING SAME TO TARGET PROTEINS TO BONE
    Publication number: 20100221234
    Abstract: A bone delivery conjugate having a structure selected from the group consisting of: A) X-Dn-Y-protein-Z; and B) Z-protein-Y-Dn-X, wherein X is absent or is an amino acid sequence of at least one amino acid; Y is absent or is an amino acid sequence of at least one amino acid; Z is absent or is an amino acid sequence of at least one amino acid; and Dn is a poly aspartate wherein n=10 to 16. Compositions comprising same and methods of use thereof.
    Type: Application
    Filed: December 15, 2009
    Publication date: September 2, 2010
    Applicant: Enobia Pharma Inc.
    Inventors: Philippe CRINE, Guy Boileau, Isabelle Lemire, Thomas P. Loisel
  • Bone delivery conjugates and method of using same to target proteins to bone
    Patent number: 7763712
    Abstract: A bone delivery conjugate having a structure selected from the group consisting of: A) X-Dn-Y-protein-Z; and B) Z-protein-Y-Dn-X, wherein X is absent or is an amino acid sequence of at least one amino acid; Y is absent or is an amino acid sequence of at least one amino acid; Z is absent or is an amino acid sequence of at least one amino acid; and Dn is a poly aspartate wherein n=10 to 16. Compositions comprising same and methods of use thereof.
    Type: Grant
    Filed: April 21, 2005
    Date of Patent: July 27, 2010
    Assignee: Enobia Pharma Inc.
    Inventors: Philippe Crine, Guy Boileau, Isabelle Lemire, Thomas P. Loisel
  • Derivatives of succinic and glutaric acids and analogs thereof useful as inhibitors of PHEX
    Patent number: 7365091
    Abstract: The present invention relates to derivatives of succinic and glutaric acids and analogues thereof, having the following general formula: useful as inhibitors of PHEX. These derivatives are useful for promoting generation of bone mass and treating or preventing diseases or conditions associated with a phosphate metabolism defect. Methods for preparation and intermediates are also disclosed.
    Type: Grant
    Filed: May 26, 2006
    Date of Patent: April 29, 2008
    Assignee: Enobia Pharma
    Inventors: Denis Gravel, Elaref S. Ratemi, Mostafa Hatam, Guy Boileau, Philippe Crine, Isabelle Lemire
  • Derivatives of succinic and glutaric acids and analogs thereof useful as inhibitors of PHEX
    Publication number: 20060287280
    Abstract: The present invention relates to derivatives of succinic and glutaric acids and analogues thereof, having the following general formula: useful as inhibitors of PHEX. These derivatives are useful for promoting generation of bone mass and treating or preventing diseases or conditions associated with a phosphate metabolism defect. Methods for preparation and intermediates are also disclosed.
    Type: Application
    Filed: May 26, 2006
    Publication date: December 21, 2006
    Applicant: Enobia Pharma
    Inventors: Denis Gravel, Elaref Ratemi, Mostafa Hatam, Guy Boileau, Philippe Crine, Isabelle Lemire
  • Derivatives of succinic and glutaric acids and analogs thereof useful as inhibitors of phex
    Patent number: 7105539
    Abstract: The present invention relates to derivatives of succinic and glutaric acids and analogues thereof, having the following general formula: useful as inhibitors of PHEX. These derivatives are useful for promoting generation of bone mass and treating or preventing diseases or conditions associated with a phosphate metabolism defect. Methods for preparation and intermediates are also disclosed.
    Type: Grant
    Filed: December 3, 2003
    Date of Patent: September 12, 2006
    Assignee: Enobia Pharma
    Inventors: Denis Gravel, Elaref S. Ratemi, Mostafa Hatam, Guy Boileau, Philippe Crine, Isabelle Lemire
  • Derivatives of succinic and glutaric acids and analogs thereof useful as inhibitors of phex
    Publication number: 20060135480
    Abstract: The present invention relates to derivatives of succinic and glutaric acids and analogues thereof, having the following general formula (I), useful as inhibitors of PHEX. These derivatives are useful for promoting generation of bone mass and treating or preventing diseases or conditions associated with a phosphate metabolism defect. Methods for preparation and intermediates are also disclosed.
    Type: Application
    Filed: December 3, 2003
    Publication date: June 22, 2006
    Applicant: Enobia Pharma
    Inventors: Denis Gravel, Elaref Ratemi, Mostafa Hatam, Guy Boileau, Philippe Srine, Isabelle Lemire
  • Bone delivery conjugates and method of using same to target proteins to bone
    Publication number: 20060014687
    Abstract: A bone delivery conjugate having a structure selected from the group consisting of: A) X-Dn-Y-protein-Z; and B) Z-protein-Y-Dn-X, wherein X is absent or is an amino acid sequence of at least one amino acid; Y is absent or is an amino acid sequence of at least one amino acid; Z is absent or is an amino acid sequence of at least one amino acid; and Dn is a poly aspartate wherein n=10 to 16. Compositions comprising same and methods of use thereof.
    Type: Application
    Filed: April 21, 2005
    Publication date: January 19, 2006
    Inventors: Philippe Crine, Guy Boileau, Isabelle Lemire, Thomas Loisel
  • Derivatives of succinic and glutaric acids and analogs thereof useful as inhibitors of phex
    Publication number: 20040186301
    Abstract: The present invention relates to derivatives of succinic and glutaric acids and analogues thereof, having the following general formula: 1
    Type: Application
    Filed: December 3, 2003
    Publication date: September 23, 2004
    Applicant: Biomep Inc.
    Inventors: Denis Gravel, Elaref S. Ratemi, Mostafa Hatam, Guy Boileau, Philippe Crine, Isabelle Lemire