Patents by Inventor ISABELLE M. MANSUY

ISABELLE M. MANSUY has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Transgenic mammals and reagents for improving long-term memory
    Publication number: 20030140360
    Abstract: The present invention provides for a transgenic nonhuman mammal whose germ or somatic cells contain a nucleic acid molecule which encodes calcineurin or a variant thereof under the control of a regulatable promoter, introduced into the mammal, or an ancestor thereof, at an embryonic stage. The present invention also provides for a method of evaluating whether a compound is effective in improving long-term memory in a subject suffering from impaired long-term memory which comprises: (a) administering the compound to the transgenic nonhuman mammal of claim 1 wherein the mammal has increased brain-specific calcineurin activity due to expression of the nucleic acid, and (b) comparing the long-term memory of the mammal in step (a) with the long-term memory of the mammal in the absence of the compound so as to determine whether the compound is effective in rescuing the long-term memory defect in the subject.
    Type: Application
    Filed: January 27, 2003
    Publication date: July 24, 2003
    Applicant: The Trustees of Columbia University in the City of New York
    Inventors: Isabelle M. Mansuy, Danny G. Winder, Mary Elizabeth Bach, Eric R. Kandel, Mark Mayford
  • MEDTHODS FOR IMPROVING LONG-TERM MEMORY STORAGE AND RETRIEVAL
    Publication number: 20020129385
    Abstract: The present invention provides for a transgenic nonhuman mammal whose germ or somatic cells contain a nucleic acid molecule which encodes calcineurin or a variant thereof under the control of a regulatable promoter, introduced into the mammal, or an ancestor thereof, at an embryonic stage. The present invention also provides for a method of evaluating whether a compound is effective in improving long-term memory in a subject suffering from impaired long-term memory which comprises: (a) administering the compound to the transgenic nonhuman mammal of claim 1 wherein the mammal has increased brain-specific calcineurin activity due to expression of the nucleic acid, and (b) comparing the long-term memory of the mammal in step (a) with the long-term memory of the mammal in the absence of the compound so as to determine whether the compound is effective in rescuing the long-term memory defect in the subject.
    Type: Application
    Filed: August 17, 1998
    Publication date: September 12, 2002
    Inventors: ISABELLE M. MANSUY, DANNY G. WINDER, MARK MAYFORD, MARY ELIZABETH BACH, ERIC R. KANDEL