Abstract: In some embodiments, an auto-index system may be provided to determine one or more candidate indexes to be automatically created in a database system. The auto-index system may determine if one or more criteria associated with creating the one or more candidate indexes are met. In response to determining that the one or more criteria associated with creating the one or more candidate indexes are met, the auto-index system may automatically create the one or more candidate indexes, for example, by an automation agent. The one or more criteria may also be associated with respective performance metrics of the database system.

Abstract: Described herein is a gene regulatory network based focused approach to cell transformation. The methods described herein allow for identification of circuit and sub-circuit repertoires for which modification in a starting cell type can result in generation of a transformed cell type in a durable and persistent manner, without requiring potentially deleterious genome modification. The described methods and compositions produced by the methods find widespread application in regenerative medicine applications.