Patents by Inventor Isabelle Sansal-Castellano

Isabelle Sansal-Castellano has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ß-1,6-glucan therapeutic antibody conjugates
    Patent number: 11865135
    Abstract: The present invention encompasses embodiments in which a therapeutic antibody is conjugated to ?-1,6-glucan oligomers. Thus, the present invention includes, among other things, compositions including a therapeutic antibody conjugated to one or more ?-1,6-glucan oligomers. The present invention further includes, among other things, methods of making and/or using such ?-1,6-glucan conjugates. In certain embodiments, a ?-1,6-glucan conjugate of the present invention is useful as a therapeutic or in a method of therapy.
    Type: Grant
    Filed: December 5, 2017
    Date of Patent: January 9, 2024
    Assignee: Innate Biotherapeutics, LLC
    Inventors: Gabriel Oscar Reznik, John James Kane, James Michael Siedlecki, Zuzana Dostalova, Isabelle Sansal-Castellano, Ifat Rubin-Bejerano, Hua Miao, Eric Steven Furfine
  • ß-1,6-GLUCAN THERAPEUTIC ANTIBODY CONJUGATES
    Publication number: 20200030360
    Abstract: The present invention encompasses embodiments in which a therapeutic antibody is conjugated to ?-1,6-glucan oligomers. Thus, the present invention includes, among other things, compositions including a therapeutic antibody conjugated to one or more ?-1,6-glucan oligomers. The present invention further includes, among other things, methods of making and/or using such ?-1,6-glucan conjugates. In certain embodiments, a ?-1,6-glucan conjugate of the present invention is useful as a therapeutic or in a method of therapy.
    Type: Application
    Filed: December 5, 2017
    Publication date: January 30, 2020
    Inventors: Gabriel Oscar Reznik, John James Kane, James Michael Siedlecki, Zuzana Dostalova, Isabelle Sansal-Castellano, Ifat Rubin-Bejerano, Hua Miao, Eric Steven Furfine
  • BETA-1,6-GLUCAN CETUXIMAB ANTIBODY CONJUGATES
    Publication number: 20180154014
    Abstract: The present invention encompasses embodiments in which cetuximab or a related cetuximab antibody is conjugated to ?-1,6-glucan oligomers. Thus, the present invention includes, among other things, compositions including cetuximab conjugated to one or more ?-1,6-glucan oligomers. The present invention further includes, among other things, methods of making and/or using such ?-1,6-glucan conjugates. In certain embodiments, a ?-1,6-glucan conjugate of the present invention is useful as a therapeutic or in a method of therapy.
    Type: Application
    Filed: June 1, 2016
    Publication date: June 7, 2018
    Inventors: Gabriel Oscar Reznik, John James Kane, James Michael Siedlecki, Zuzana Dostalova, Isabelle Sansal-Castellano, Ifat Rubin-Bejerano, Hua Miao
  • COMPOSITIONS AND METHODS FOR CANCER IMMUNOTHERAPY
    Publication number: 20170369570
    Abstract: The present invention includes, among other things, ?-1,6-glucan linked to an antibody directed to a cell present in a tumor microenvironment. T regulatory cells can be one type of cell present in the tumor microenvironment. In particular embodiments, the antibody is directed to a surface feature of a T regulatory cell, MDSC, or other immune cell. In certain embodiments, the antibody is directed to T regulatory cells, MDSCs, or other immune cells present in a tumor microenvironment. Compositions including ?-1,6-glucan linked to an antibody directed to a T regulatory cell, MDSC, or other immune cell may be useful, e.g., in the treatment of a tumor or cancer in a subject in need thereof. Accordingly, the present invention provides, among other things, methods and compositions for treatment of a tumor or cancer.
    Type: Application
    Filed: January 20, 2016
    Publication date: December 28, 2017
    Inventors: Ifat Rubin-Bejerano, Gabriel Oscar Reznik, Zuzana Dostalova, Isabelle Sansal-Castellano