Patents by Inventor Isabelle VILLEY

Isabelle VILLEY has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NON-BIOCONVERTIBLE C3-SUBSTITUTED PREGNENOLONE DERIVATIVES FOR USE IN THE TREATMENT OF SUBSTANCE USE DISORDERS
    Publication number: 20210322443
    Abstract: The present invention relates to the use of non-bioconvertible C3-substituted pregnenolone derivatives of formula (I), with no significant affinity for hormonal receptors or receptors of the central nervous system, in the treatment of substance use disorders, and in particular of alcohol use disorder.
    Type: Application
    Filed: June 29, 2021
    Publication date: October 21, 2021
    Applicant: MAPREG
    Inventors: George F. KOOB, Barbara JEAN MASON, Olivier GEORGE, Etienne BAULIEU, Isabelle VILLEY
  • Non-bioconvertible C-substituted pregnenolone derivatives for use in the treatment of substance use disorders
    Patent number: 11077122
    Abstract: The present invention relates to the use of non-bioconvertible C3-substituted pregnenolone derivatives of formula (I), with no significant affinity for hormonal receptors or receptors of the central nervous system, in the treatment of substance use disorders, and in particular of alcohol use disorder.
    Type: Grant
    Filed: November 4, 2016
    Date of Patent: August 3, 2021
    Assignee: MAPREG
    Inventors: George F. Koob, Barbara Jean Mason, Olivier George, Etienne Baulieu, Isabelle Villey
  • NON-BIOCONVERTIBLE C3-SUBSTITUTED PREGNENOLONE DERIVATIVES FOR USE IN THE TREATMENT OF SUBSTANCE USE DISORDERS
    Publication number: 20180318317
    Abstract: The present invention relates to the use of non-bioconvertible C3-substituted pregnenolone derivatives of formula (I), with no significant affinity for hormonal receptors or receptors of the central nervous system, in the treatment of substance use disorders, and in particular of alcohol use disorder.
    Type: Application
    Filed: November 4, 2016
    Publication date: November 8, 2018
    Inventors: George F. KOOB, Barbara JEAN MASON, Olivier GEORGE, Etienne BAULIEU, Isabelle VILLEY
  • Non-bioconvertible C-substituted pregnenolone derivatives for use in the treatment of treatment-resistant depression
    Patent number: 9943528
    Abstract: The present invention relates to methods for the treatment of treatment-resistant depression (TRD), comprising the administration of compounds of formula (I), which are blocked in C3 position and cannot metabolize in vivo into pregnenolone derivatives and which do not have significant affinity for steroid hormonal receptors and for all tested classical main receptors and receptors of neurotransmitters of the central nervous system.
    Type: Grant
    Filed: February 28, 2017
    Date of Patent: April 17, 2018
    Assignee: MAPREG
    Inventors: Massimiliano Bianchi, Etienne Baulieu, Isabelle Villey
  • Non-Bioconvertible C3-Substituted Pregnenolone Derivatives for Use in the Treatment of Treatment-Resistant Depression
    Publication number: 20170252358
    Abstract: The present invention relates to methods for the treatment of treatment-resistant depression (TRD), comprising the administration of compounds of formula (I), which are blocked in C3 position and cannot metabolize in vivo into pregnenolone derivatives and which do not have significant affinity for steroid hormonal receptors and for all tested classical main receptors and receptors of neurotransmitters of the central nervous system.
    Type: Application
    Filed: February 28, 2017
    Publication date: September 7, 2017
    Applicant: MAPREG
    Inventors: Massimiliano BIANCHI, Etienne BAULIEU, Isabelle VILLEY